Chemical characterization and biological activities of the genus Tanacetum (Compositae)

Gören, Nezhun; Arda, Nazlı; Caliskan, Zerrin Zerenler

doi:10.1016/s1572-5995(02)80044-8

Cited by 25 publications

(19 citation statements)

References 153 publications

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“…Also there are cases of contact dermatitis caused by this plant 3) . Reports indicate that sesquiterpene lactone content of T. parthenium is responsible for the observed activities 4) . Active principle is reported to be parthenolide; which is a potential agent due to its antimigraine 5) , antitumor [6][7][8] , antileishmanial 9) , antiparasitic 10) and antiinflammatory 11) properties.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and the Variation of Tanacetum parthenium (L.) Schultz Bip. Essential Oils from Turkey

et al. 2010

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Water-distilled essential oils from herbal parts of Tanacetum parthenium from two different localities in Turkey were analyzed by GC and GC/MS. The essential oil of T. parthenium collected from Davutpaşa-İstanbul location were characterized with camphor 49%, trans-chrysanthenyl acetate 22.1% and camphene 9.4%. Second plant sample is collected from the remote east end of the country Şavşat-Ardahan location. The essential oil from this location was characterized with camphor 60.8% and camphene 6.8%. Unlike the former this sample contains trans-chrysanthenyl acetate in trace amount and cis-chrysanthenyl acetate in very small amount (0.6%) which is not present in the first sample. Antibacterial activity of the oils were evaluated for five Gram (+) and five Gram (-) bacteria by using a broth microdilution assay. The highest activity was observed on Bacillus subtilis, Staphylococcus aureus and methicillin-resistant S.aureus however when compared with positive control oils showed higher MIC values. The oil of İ stanbul-sample showed highest activity on B. subtilis (125 mg/mL) and methicillinresistant S. aureus (125 mg/mL) which is two fold concentration when compared with the positive control chloramphenicol (62.5 mg/mL). The oil of Ardahan sample showed the highest activity on S. aureus (125 mg/mL) which is likewise two fold concentration of the positive control chloramphenicol (62.5 mg/mL). DPPH scavenging activity was 59.3% of the oil from Davutpaşa at 15mg/mL concentration. When compared to positive control a-tocopherol (94.6%) Şavşat oil (28.2%) showed low and Davutpaşa oil showed medium DPPH scavenging activity. All of the oils showed toxicity to Vibrio fischeri in the TLCbioluminescence assay.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and the Variation of Tanacetum parthenium (L.) Schultz Bip. Essential Oils from Turkey

et al. 2010

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“…canum contain parthenolide. 3 The activities of the n-hexane extract and the ethyl acetate extract may be associated with the plant's major component parthenolide.…”

Section: Resultsmentioning

confidence: 99%

“…7 Sesquiterpenoids are thought to be the bioactive constituents of this taxon. 3 The major compounds of the essential oil of the plant are reported as monoterpenes; α-pinene, β-pinene and santolinatriene by previous studies. [7][8][9] Caryophyllene oxide and α-thujone were found as the main constituents of the oil of T. argenteum subsp.…”

Section: Introductionmentioning

confidence: 96%

“…2 The genus is distributed in Europe and West Asia and all over Turkey, excluding the Aegean side. 3,4 Tanacetum sp. are used as insecticides, tonic, appetizers, anthelmintics, diuretics, carminatives, stimulants, emmenagogues, antipyretics, and antimigraine agents in Turkey.…”

Section: Introductionmentioning

confidence: 99%

“…It is known as having antimigraine properties and is used to relieve menstrual pain in traditional medicine, and standardized capsules of leaf extract are available on the market. 3,6 Eudesmane sesquiterpenes are the main components of the genus. Tanacetum argenteum.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Cytotoxic and Anti-inflammatory Activities of Tanacetum argenteum (Lam.) Willd. subsp. argenteum Extract

Albayrak¹,

Nalbantsoy²,

Baykan³

2017

tjps

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Amaç: Tanacetum argenteum subsp. argenteum bitkisinin hekzan, etil asetat ve metanol ekstrelerinin anti-inflamatuvar ve sitotoksik potansiyellerini incelemektir. Gereç ve Yöntemler: Tanacetum L. Asteraceae familyasının en büyük 3. cinsidir ve Türkiye florasında 60 taksonla temsil edilir. Seskiterpen laktonlar ve piretrinler cinsin ana kimyasal gruplarıdır. T. argenteum subsp. argenteum İç ve Güney Anadolu'da yayılış gösteren endemik bir taksondur. Bulgular: In vitro anti-inflamatuvar aktivite iNOS ve NF-κB inhibisyon metodlarıyla RAW264.7 ve HeLa hücrelerine karşı test edilmiştir. Sitotoksik aktivite MTT metoduyla 10 hücre hattına karşı denenmiştir. Sonuç: Sonuç olarak, n hekzan ekstresi iNOS testinde (IC 50 : 0.627±0.16 µg/mL) ve PC3 ve MPANC-96 hücreleri (IC 50 : 2.85±0.51 µg/mL ve 5.35±1.24 µg/mL, sırasıyla) üzerinde yapılan sitotoksik ölçümlerde pozitif kontrol partenolitten daha etkili bulunmuştur. Anahtar kelimeler: Tanacetum argenteum subsp. argenteum, anti-inflamatuvar, NF-κB, iNOS, sitotoksisite, MTT Objectives: The objective of this study was to examine the anti-inflammatory and cytotoxic potential of n-hexane, ethyl acetate, and methanolic extracts of Tanacetum argenteum subsp. argenteum. Materials and Methods: Tanacetum L. is the third largest genus of Asteraceae family and is represented by 60 taxa in Turkish flora. Sesquiterpene lactones and pyrethrins are the main chemical groups of the genus. T. argenteum subsp. argenteum is an endemic taxa that is distributed in the Central and South Anatolia. Results:In vitro anti-inflammatory activity was assayed using iNOS and NF-κB inhibition tests on RAW264.7 and HeLa cells. The cytotoxic activities were tested against ten cell lines using MTT assays. Conclusion: As a result, the n-hexane extract was found more active than the positive control parthenolide in iNOS test (IC 50 : 0.627±0.16 µg/mL) and cytotoxic experiments against PC3 and MPANC-96 cell lines (IC 50 : 2.85±0.51 µg/mL and 5.35±1.24 µg/mL, respectively).

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Combining chemical profiles and biological abilities of different extracts from Tanacetum nitens (Boiss. & Noë) Grierson using network pharmacology

Dall'Acqua,

Yagi,

Sut

et al. 2024

Archiv der Pharmazie

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Tanacetum nitens ( Boiss. & Noë) Grierson is an aromatic perennial herb used in Turkish traditional medicine to treat headache, fever, and skin diseases. This study aimed to investigate the chemical composition, antioxidant, enzyme inhibition, and cytotoxic properties of T. nitens aerial parts. Organic solvent extracts were prepared by sequential maceration in hexane, dichloromethane, ethyl acetate, and methanol while aqueous extracts were obtained by maceration or infusion. Nuclear magnetic resonance (NMR) and LC‐DAD‐MS analysis allowed the identification and quantification of different phytoconstituents including parthenolide, tanacetol B, tatridin B, quinic acid derivatives, β‐sitosterol, and glycoside derivatives of quercetin and luteolin. The type and amount of these phytochemicals recovered by each solvent were variable and significant enough to impact the biological activities of the plant. Methanolic and aqueous extracts displayed the highest scavenging and ions‐reducing properties while the dichloromethane and ethyl acetate extracts exerted the best total antioxidant activity and metal chelating power. Results of enzyme inhibition activity showed that the hexane, ethyl acetate, and dichloromethane extracts had comparable anti‐acetylcholinesterase activity and the latter extract revealed the highest anti‐butyrylcholinesterase activity. The best α‐amylase and α‐glucosidase inhibition activities were obtained from the hexane extract. The dichloromethane and ethyl acetate extracts exhibited the highest cytotoxic effect against the prostate carcinoma DU‐145 cells. In conclusion, these findings indicated that T. nitens can be a promising source of biomolecules with potential therapeutic applications.

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Chemical characterization and biological activities of the genus Tanacetum (Compositae)

Cited by 25 publications

References 153 publications

Antibacterial Activity and the Variation of Tanacetum parthenium (L.) Schultz Bip. Essential Oils from Turkey

Antibacterial Activity and the Variation of Tanacetum parthenium (L.) Schultz Bip. Essential Oils from Turkey

<i>In Vitro</i> Cytotoxic and Anti-inflammatory Activities of <i>Tanacetum argenteum</i> (Lam.) Willd. subsp. <i>argenteum</i> Extract

Combining chemical profiles and biological abilities of different extracts from Tanacetum nitens (Boiss. & Noë) Grierson using network pharmacology

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