Chemical characterization and biological activity of essential oils from the aerial part and root ofFerula haussknechtii

Abstract

Ferula genus belongs to Umbelliferae family. Plants with this kind of genus are distributed in an extended region such as central Asia and Mediterranean area. Ferula species are used in traditional medicine as a remedy in different kinds of illnesses and also in different kinds of industries. The Ferula haussknechtii H. Wolff ex Rech. f. is one of the flora species in Iran which in this research the essential oil of its aerial parts and root was extracted by Clevenger apparatus. After that, theirs compounds were recognized using gas chromatography methods (GC‐MS and GC‐FID) and their amount was determined. Antibacterial activity of essential oils was examined, and phytochemical screening on the plant's extracts was done too. GC‐MS/FID method identified 62 compounds in root and 64 compounds in aerial parts of this plant which were 94.6 and 92.8 percent of their respective whole essential oil. Camphene, α‐pinene, and isoverbanol had the most percent in both essential oils. Antibacterial tests on root and aerial parts of plant essential oils on 4 g‐negative and 5 g‐positive bacteria were done. Results concluded that essential oils were effective on the Bacillus pumilus, Staphylococcus epidermidis, and Staphylococcus aureus (17‐18mm, 7.5 mg/mL); therefore, this plant can be useful in medicine and food industry as an antibacterial agent.

Deep learning model for classification and bioactivity prediction of essential oil-producing plants from Egypt

“…EOs are considered as one of the well-known natural products which have medical-relevant use and biological-defense activities against several types of viruses, bacteria, and cancer 11 . However, the lack of the complete information about their intrinsic chemical variability and their function makes it difficult to confirm its consistent activities 4 . Many researchers have adopted the AI in EO's researches aiming to reduce the in-vitro procedures and to make reasonable predications of the experiment results.…”

“…The biological activities of the EOs may include antiseptics, antimicrobials, antifungals, antioxidant, antitumor, antivirals, and/or anti-inflammatories. Moreover, these activities vary according to the chemical constitution, which may differ from plant to another according to their geographic location, agriculture conditions, climatic or seasonal changes 4 . Noteworthy, the evaluation of the EOs' bioactivities cannot be constantly credited to one single compound in the EOs mixture.…”

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

“…The F. haussknechtii essential oil, which was extracted by the Clevenger apparatus contained camphene, α-pinene, and isoverbanol as abundant chemical constituents; these compounds exhibited antibacterial activity against nine bacterial strains. The result showed that Bacillus pumilus, Staphylococcus epidermidis and S. aureus were more sensitive to the essential oil among other tested bacterial strains (Arjmand and Dastan, 2020). Alipour et al, (2015) enumerated the bactericidal activity of the essential oil acquired from stem, leaf, and flower parts of the Ferula cupularis Boiss.…”

“…Generally, aromatic acid lactones sesquiterpenes, coumarins, and sesquiterpene coumarins are present in the roots of Ferula species (Teng et al, 2013), whereas monoterpenes, oxygenated monoterpenoids sesquiterpenes and oxygenated sesquiterpenoid are the main chemical constituents of essential oil present in the aerial parts of Ferula (Mohammadhosseini et al, 2015). Due to the widespread therapeutic effects of this genus, it is being used in folk medicine to treat a variety of diseases and disorders, including skin infections, psychiatric disorders (especially seizure), hyperlipidemia, diabetes, arteries sclerosis, digestive disorders (dysentery), osteoporosis, arthritis, HIV, influenza type A, cancers (uterine cancer), muscle relaxant, rheumatism, headaches, hypertension, toothache and dizziness (Zhou et al, 2017;Meena et al, 2018;Arjmand and Dastan, 2020;Esmaeili et al, 2020).…”

Chemical Constituents of the Volatile and Nonvolatile, Cytotoxic and Free Radical Scavenging Activities of Medicinal Plant: <i>Ranunculus millefoliatus</i> and <i>Acanthus dioscoridis</i>

“…For nonvolatile phytochemical analysis of the methanolic extract was carried out using standard procedures to identify of the existence or nonexistence of various constituents such as saponins, alkaloid, flavonoid, terpenoids, tannins, phlobatannin, steroid, phenols proteins, carbohydrate, proteins and glycosides compounds [21][22].…”