Chemical characterization of billy goat weed extracts Ageratum conyzoides (Asteraceae) and their mosquitocidal activity against three blood-sucking pests and their non-toxicity against aquatic predators

Ramasamy, Venkatachalam; Karthi, Sengodan; Ganesan, Raja; Prakash, Palanisamy; Senthil‐Nathan, Sengottayan; Umavathi, S.; Krutmuang, Patcharin; Vasantha-Srinivasan, Prabhakaran

doi:10.1007/s11356-021-12362-6

Cited by 15 publications

(7 citation statements)

References 56 publications

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“…This indicated the toxic substance ingested had exhibited some chronic toxicity. These results were also noticed in S. litura when treated with Trichilia americana [ 14 ]. Andrographolide had shown reduced growth rate, consumption rate, consumption index and conversion of ingested food, but showed higher approximate digestibility.…”

Section: Discussionsupporting

confidence: 54%

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Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

et al. 2021

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Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development. Plant-derived diterpenoid compound andrographolide was isolated from the leaves of Andrographis paniculata. It was analysed by gas chromatography-mass spectroscopy and quantified by HPLC. Nutritional indices and digestive enzymatic profile were evaluated. Third, fourth and fifth instar larvae were treated with different concentrations of andrographolide. At 3, 6 and 9 ppm-treated concentrations the larvae showed decreased RGR, RCR, ECI, ECD values with adverse increase in AD. The digestive enzymes were significantly inhibited when compared with control. Conspicuously, andrographolide showed pronounced mortality of S. litura by inhibition of enzyme secretion and intake of food. The binding ability of andrographolide with CYTP450 showed high affinity with low binding energy. Andrographolide has the potential to be exploited as a biocontrol agent against S. litura as an eco-friendly pesticide.

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Section: Discussionsupporting

confidence: 54%

“…Food consumption and enzyme activity are mainly affected by secondary metabolites which are deleterious to insects [ 14 , 15 ]; they also bring almost stunted growth of late instars [ 16 ]. Damage of peritrophic membrane in the insect gut causes a significant reduction in food utilization [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

et al. 2021

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“…aegypti . Also, the sub-lethal dosage of A. conyzoides blocked the activity of CarE activity 46 . As well, the Sophora alopecuroides alkaloids are involved in the inhibition of CarE activity in Aedes albopictus 47 .…”

Section: Discussionmentioning

confidence: 93%

“…Petroleum ether extract of A. conyzoides showed significant larvicidal activity against the 4th larval instars, adult mortality and affected percentages of oviposition deterrence index of females of three mosquito vectors. Beside to, these extracts harmless to aquatic mosquito predator Toxorhynchites splendens even at the prominent dosage (1000 ppm) 46 . The A. conyzoides ethanolic extract has acaricidal potency against acaricides- susceptible and resistant ticks infesting buffaloes and cattle, moreover, adversely affected egg laying capacity 35 .…”

Section: Discussionmentioning

confidence: 99%

Larvicidal and repellent potential of Ageratum houstonianum against Culex pipiens

Hadidy

Sayed

Tantawy

et al. 2022

Sci Rep

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Mosquitoes are unquestionably the most medic arthropod vectors of disease. Culex pipiens, usually defined as a common house mosquito, is a well-known carrier of several virus diseases. Crude ethanol extracts of different organs of Agratum houstonianum are tested with Culex pipiens Linnaeus (Diptera: Culicidae) to determine their larvicidal, antifeedant, and repellency effects. Alongside biochemical analysis, the activity of the AChE, ATPase, CarE, and CYP-450 is detected in the total hemolymph of the C. pipiens larvae to examine the enzymatic action on the way to explain their neurotoxic effect and mode of action. Through HPLC and GC–MS analysis of the phytochemical profile of A. houstonianum aerial parts is identified. The larvicidal activity of aerial parts; flower (AF), leaf (AL), and stem (AS) of A. houstonianum extracts are evaluated against the 3rd instar larvae of C. pipiens at 24-, 48- and 72-post-treatment. A. houstonianium AF, AL, and AS extracts influenced the mortality of larvae with LC50 values 259.79, 266.85, and 306.86 ppm, respectively after 24 h of application. The potency of AF and AL extracts was 1.69- and 1.25-folds than that of AS extract, respectively. A high repellency percentage was obtained by AF extract 89.10% at a dose of 3.60 mg/cm2. A. houstonianium AF prevailed inhibition on acetylcholinesterase and decrease in carboxylesterase activity. Moreover, a significant increase in the ATPase levels and a decrease in cytochrome P-450 monooxegenase activity (− 36.60%) are detected. HPLC analysis prevailed chlorogenic and rosmarinic acid as the major phenolic acids in AL and AF, respectively. GC–MS analysis of A. houstonianum results in the identification of phytol as the major makeup. Precocene I and II were detected in AF. Linoleic, linolenic, and oleic acid were detected in comparable amounts in the studied organs. Overall, results suggest that the A. houstonianum flower extract (AF) exhibits significant repellent, antifeedant, and larvicidal activities.

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“…The oil may also induce abnormalities at the phenotypic or genotypic level in the larvae of Aedes , Anopheles , and Culex spp. [ 58 ]. The weed has also shown promising results against plant and animal pests such as Rhipicephalus microplus , Phytophthora megakarya , Diaphania hyalinata , Tribolium castaneum , Helicoverpa armigera , Plutella xylostella, etc.…”

Section: Biological Activitymentioning

confidence: 99%

Ecology, Biology, Environmental Impacts, and Management of an Agro-Environmental Weed Ageratum conyzoides

Kaur

Singh

et al. 2023

Plants

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Ageratum conyzoides L. (Billy goat weed; Asteraceae) is an annual herbaceous plant of American origin with a pantropical distribution. The plant has unique biological attributes and a raft of miscellaneous chemical compounds that render it a pharmacologically important herb. Despite its high medicinal value, the constant spread of the weed is noticeable and alarming. In many countries, the weed has severely invaded the natural, urban, and agroecosystems, thus presenting management challenges to natural resource professionals and farmers. Its interference with agricultural crops, grassland forbs, forest ground flora, and its ability to replace native plant species are of serious concern. Therefore, it is pertinent to monitor its continuous spread, its entry into new geographic regions, the extent of its impact, and the associated evolutionary changes. While management strategies should be improvised to control its spread and reduce its adverse impacts, the possible utilization of this noxious weed for pharmacological and agronomic purposes should also be explored. The objective of this review is to provide a detailed account of the global distribution, biological activities, ecological and environmental impacts, and strategies for the management of the agro-environmental weed A. conyzoides.

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Chemical characterization of billy goat weed extracts Ageratum conyzoides (Asteraceae) and their mosquitocidal activity against three blood-sucking pests and their non-toxicity against aquatic predators

Cited by 15 publications

References 56 publications

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

Larvicidal and repellent potential of Ageratum houstonianum against Culex pipiens

Ecology, Biology, Environmental Impacts, and Management of an Agro-Environmental Weed Ageratum conyzoides

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