Chemical characterization of two fractions from Sanghuangporus sanghuang and evaluation of antidiabetic activity

Hou, Ranran; Zhou, Lin-Jiang; Fu, Yan; Wang, Tong; Li, Zhe; Zhou, Li-Wei; Zhang, Guoli; Tian, Xue-Mei

doi:10.1016/j.jff.2021.104825

Cited by 13 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 There are various confusing names for Sanghuangporus – Phellinus linteus , Phellinus bawmii , Inonotus sanghuang , “Sanghuang”, and others. 20–22 Therefore, a new genus of Sanghuangporus was posed, which includes 14 species, mainly S. sanghuang , S. baumii , and S. vaninii . 23 In recent years, some modern pharmacological studies have shown that “Sanghuang” has anti-tumor, hypoglycemic, antioxidant, and hepatoprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Huang

Liu

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Huang

Liu

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Due to its particular pharmacological effects and high level of safety ( Huo et al, 2020 ), Sanghuangporus has attracted extensive attention from scholars worldwide in recent years ( Jiang et al, 2021 ). Many studies have shown that Sanghuangporus sanghuang has excellent antitumor, anti-inflammatory, and antioxidant activities and hypoglycaemic effects ( Lin et al, 2017a ; Lin et al, 2017b ; Cai et al, 2019 ; Wan et al, 2020 ); its potential as a treatment for diabetes and gout has also been revealed in recent years ( Guo et al, 2021 ; Hou et al, 2021 ); polysaccharides, polyphenols, pyrones, and terpenes are the main metabolites that are responsible for these medicinal functions ( Cai et al, 2019 ). In recent decades, from the first time that “ Sanghuang ” has been referred to by the scientific fungal genus name Sanghuangporus , the commercialization and industrialization of S. sanghuang has also developed rapidly ( Zhou et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1

et al. 2023

View full text Add to dashboard Cite

Sanghuangporus Sanghuang is a fungus species. As a traditional Chinese medicine, it is known for antitumor, antioxidant and anti-inflammatory properties. However, the antiaging effect of S. Sanghuang has not been deeply studied. In this study, the effects of S. Sanghuang extract (SSE) supernatants on the changes of nematode indicators were investigated. The results showed that different concentrations of SSE prolonged the lifespans of nematodes and substantially increased these by 26.41%. In addition, accumulations of lipofuscin were also visibly reduced. The treatment using SSE also played a role in increasing stress resistance, decreasing ROS accumulations and obesity, and enhancing the physique. RT–PCR analysis showed that the SSE treatment upregulated the transcription of daf-16, sir-2.1, daf-2, sod-3 and hsp-16.2, increased the expression of these genes in the insulin/IGF-1 signalling pathway and prolonged the lifespans of nematodes. This study reveals the new role of S. Sanghuang in promoting longevity and inhibiting stress and provides a theoretical basis for the application of S. Sanghuang in anti-ageing treatments.

show abstract

“…It was later distinguished as a new species, Inonotus sanghuang , in 2012 [ 2 ] and retitled S. sanghuang in 2016 [ 3 ]. Numerous studies have shown that S. sanghuang exhibits various biological activities such as hypoglycemic [ 4 ], antioxidant [ 5 , 6 ], antitumor, antibacterial [ 7 ], antidiabetic [ 8 ], and anti-inflammatory effects [ 9 ]. Triterpenoids are the main active components of S. sanghuang [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

Zhou

Zhang

et al. 2023

JoF

Self Cite

View full text Add to dashboard Cite

Sanghuangporus sanghuang is a large wood-decaying mushroom highly valued in traditional Chinese medicine due to its medicinal properties, including hypoglycemic, antioxidant, antitumor, and antibacterial properties effects. Its key bioactive compounds include flavonoids and triterpenoids. Specific fungal genes can be selectively induced by fungal elicitors. To investigate the effect of fungal polysaccharides derived from Perenniporia tenuis mycelia on the metabolites of S. sanghuang, we conducted metabolic and transcriptional profiling with and without elicitor treatment (ET and WET, respectively). Correlation analysis showed significant differences in triterpenoid biosynthesis between the ET and WET groups. In addition, the structural genes associated with triterpenoids and their metabolites in both groups were verified using quantitative real-time polymerase chain reaction (qRT-PCR) and high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). Through metabolite screening, three triterpenoids were identified: betulinol, betulinic acid, and 2-hydroxyoleanolic acid. Excitation treatment increased the level of betulinic acid by 2.62-fold and 2-hydroxyoleanolic acid by 114.67-fold compared to WET. The qRT-PCR results of the four genes expressed in secondary metabolic pathways, defense gene activation, and signal transduction showed significant variation between the ET and WET groups. Overall, our study suggests that the fungal elicitor induced the aggregation of pentacyclic triterpenoid secondary metabolites in S. sanghuang.

show abstract

Chemical characterization of two fractions from Sanghuangporus sanghuang and evaluation of antidiabetic activity

Cited by 13 publications

References 40 publications

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

Contact Info

Product

Resources

About