Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Xxxiv. Comparative Studies on the Nutritive Value of Orally and Intravenously Administered Human Serum Albumin in Man 123

Eckhardt, Richard D.; Lewis, Jessica H.

doi:10.1172/jci101915

Cited by 47 publications

(21 citation statements)

References 14 publications

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“…The values obtained for decay are compared with the sum of burning and conversion in Table IV and are expressed cumulatively as grams of nitrogen. The formula used for computing decay is that given for a series of daily injections (12). One sees fair correlation in the three patients, G. V., W. R., and Eugene G. This positive correlation we be- The mechanism of the proteinuria, which eventually occurred in all our patients, requires brief comment.…”

Section: Fig 19mentioning

confidence: 63%

“…The nutritive response as determined by the nitrogen balance deserves some comment even though this has been well described by other authors (12,26). A positive nitrogen balance was present in all our patients at all times during the administration of albumin with the one exception of G. V. at a time when proteinuria was excessive.…”

Section: Fig 19mentioning

confidence: 70%

“…Yet in view of the reported deficiencies, studies on the nutritive value of albumin for man should be pertinent. Eckhardt and others (12) were unable to maintain nitrogen balance when 245 37. 5 Gins.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Studies on Protein-Depleted Patients Receiving a Large Part of Their Nitrogen Intake From Human Serum Albumin Administered Intravenously 12

Waterhouse¹,

Bassett²,

Holler³

et al. 1949

J. Clin. Invest.

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Section: Fig 19mentioning

confidence: 63%

Section: Fig 19mentioning

confidence: 70%

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Metabolic Studies on Protein-Depleted Patients Receiving a Large Part of Their Nitrogen Intake From Human Serum Albumin Administered Intravenously 12

Waterhouse¹,

Bassett²,

Holler³

et al. 1949

J. Clin. Invest.

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“…Utilizing the fluorescent antibody technique, Gitlin, Landing and Whipple (15) have demonstrated homologous serum albumin intracellularly in a variety of human tissues. In addition, it seems clear that circulating albumin may serve as a general body nitrogen source (16).…”

Section: Discussionmentioning

confidence: 99%

Studies of Iodoalbumin Metabolism. Ii. The Effects of Thyroid Hormone*

Lewallen¹,

Rall²,

Berman³

1959

J. Clin. Invest.

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“…nitrogen daily) but adequate in calories, vitamins, and salts was used in all studies. Its composition has been described previously (11). All amino acid analyses were by microbiological assay (8).…”

Section: Methodsmentioning

confidence: 99%

The Oral and Parenteral Phenylalanine Requirements for Nitrogen Equilibrium in Man 1

Eckhardt¹,

Davidson²,

Hirshberg³

1948

J. Clin. Invest.

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From published data on the minimum quantity of whole protein (milk, soy flour, white flour, and egg) required (1) or estimated (2) to maintain nitrogen balance in adults, and from analytical data of the amino acid content of these proteins (3), Harte and Travers (4) have calculated the "minimum" requirements for man of the essential amino acids. For phenylalanine, 1.4 Gm. daily was considered to be sufficient. The observations reported here indicate that the daily phenylalanine requirement for man is greater when the daily protein intake (protein hydrolysate) is given intravenously than when given orally. These studies were made during the course of investigations employing as a sole source of nitrogen a 10 per cent solution of amino acids2 prepared by complete acid hydrolysis of casein, largely freed of glutamic and aspartic acids, and supplemented with dl-tryptophane, dl-methionine, and glycine (5, 6). MATERIALS AND METHODSIn Table I the composition of two lots of the solution of amino acids with respect to the 8 amino acids essential for man (7) and for arginine and histidine is shown and is compared to that of casein. The results are based on analyses by microbiological assay (8,9,10). Likewise the quantity of amino acids in 1,000 cc. of this 10 per cent solution (average of the two nearly identical lots) is compared with the "minimum" amino acid requirements calculated by Harte and Travers (4). It is apparent that from 2 to 15 times these "minimum" quantities of amino acids are supplied in 1,000 cc. of the solution with the exception of phenylalanine, which might therefore be expected to be the "limiting" amino acid in this solution. The low phenylalanine content of these particular lots (1.7 per cent and 1.9 per cent) enabled us to investigate the effect on the nitrogen bal-1 The expenses of this investigation were defrayed in part by a

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Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Xxxiv. Comparative Studies on the Nutritive Value of Orally and Intravenously Administered Human Serum Albumin in Man 123

Cited by 47 publications

References 14 publications

Metabolic Studies on Protein-Depleted Patients Receiving a Large Part of Their Nitrogen Intake From Human Serum Albumin Administered Intravenously 12

Metabolic Studies on Protein-Depleted Patients Receiving a Large Part of Their Nitrogen Intake From Human Serum Albumin Administered Intravenously 12

Studies of Iodoalbumin Metabolism. Ii. The Effects of Thyroid Hormone*

The Oral and Parenteral Phenylalanine Requirements for Nitrogen Equilibrium in Man 1

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