Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Xix. A Note on the Use of Fibrinogen and Thrombin in the Surface Treatment of Burns 123

Abstract

When, in the early phases of the N-ar, the number of burn casualties made the treatment of this group of lesions a problem of considerable importance, the need for an agent in the surface therapy of burns w-hich would meet the 4 following criteria was pointed out to those engaged in the plasma fractionation program:1. It should lack the deleterious effect on healing possessed by the conventional escharotics (1 to 3).2. It should possess properties of high stabilitv and low bull from the standpoint of transportation.3. It shoulcl be susceptible of simple and speedy application.4. It should possess requisite mechanical properties to permit immediate mobilizatioin of casualties under field conditions. At this time it became apparent that large quantities of purified human fibrinogen and thrombin were becoming available through the

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Xvi. Fibrin Clots, Fibrin Films, and Fibrinogen Plastics 12

“…The possible value of these fabric-backed and waterproof films is discussed in another paper of this series (9).…”

Discussion on the Factors Concerned in Blood Coagulation and Their Clinical Significance

“…They have produced a series of "plasticized" products, in which the permeability dnd liability to lysis have been reduced (Ferry and Morrison, 1944). These products have been used as a dressing for burns (Hawn, et al, 1944), as a hiemostatic agent , as a filling for the cavities left after the removal of cerebral tumours and as a dural substitute in neurosurgery (Bailey and Ingraham, 1944). The great advantage of these products is that being a physiological substance fibrin can be left in situ to be removed by the ordinary process of healing and repair.…”