Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides

Song, Jing‐Zheng; Yiu, Hillary; Qiao, Chun‐Feng; Han, Quan‐Bin; Xu, Hong‐Xi

doi:10.1016/j.jpba.2007.12.036

Cited by 79 publications

(62 citation statements)

References 27 publications

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“…Astragalus membranaceus is commonly used in Traditional Chinese Medicine to treat a variety of diseases [15]. Astragaloside IV, the component of Astragalus membranaceus, exhibits anti-oxidant, anti-cancer and neuro-protective properties [16].…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

Liu

et al. 2016

Cell Physiol Biochem

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Background: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and immunoregulatory properties. In the present study, we investigated the role of astragaloside IV in the chemoresistance to cisplatin in NSCLC cells. Methods: We established astragaloside IV-suppressed NSCLC cell lines including A549, HCC827, and NCI-H1299 and evaluated their sensitivity to cisplatin in vitro. In addition, we examined the mRNA and protein levels of B7-H3 in response to cisplatin-based chemotherapy. Results: We showed that high doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC cell growth, whereas low concentrations of astragaloside IV (1, 2.5, 5 ng/ml) had no obvious cytotoxicity on cell viability. Moreover, combined treatment with astragaloside IV significantly increased chemosensitivity to cisplatin in NSCLC cells. On the molecular level, astragaloside IV co-treatment significantly inhibited the mRNA and protein levels of B7-H3 in the presence of cisplatin. In addition, ectopic expression of B7-H3 diminished the sensitization role of astragaloside IV in cellular responses to cisplatin in NSCLC cells. Conclusion: These results demonstrate that astragaloside IV enhances chemosensitivity to cisplatin via inhibition of B7-H3 and that treatment with astragaloside IV and inhibition of B7-H3 serve as potential therapeutic approach for lung cancer patients.

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Section: Introductionmentioning

confidence: 99%

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

Liu

et al. 2016

Cell Physiol Biochem

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“…Constituents in either xylem or bark were divided into five groups according to their chemical structures Group 1, contained calycosin and related constituents; Group 2, contained ononin and related constituents; Group 3, contained (6aR,11aR)-3-hydroxy-9,10-dimethoxypterocarpan and related constituents; Group 4, contained (3R)-7,2 0 -dihydroxy-3 0 ,4 0 -dimethoxyisoflavan and related constituents; and Group 5, contained astragalosides, compounds AG I, AG II, and AG IV (Song et al 2008). …”

Section: Triterpenoid Saponins (Astragalosides)mentioning

confidence: 99%

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

Lü

2013

Parasitology Research Monographs

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Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis, a widespread infection, with clinical spectrum ranging from a completely asymptomatic infection to multiorgan involvement. Novel medicines effective against both active and latent forms of the parasite are greatly needed. To review current evidence for antitoxoplasmosis by Traditional Chinese Medicine (TCM), our literature focused on five kinds of Chinese herbs, including Torilis japonica, Zingiber officinale, Sophora flavescens, Astragalus membranaceus, and Scutellaria baicalensis GEORGI in our present study, which are used in TCM for the treatment of allergic inflammatory diseases, infectious diseases such as bacterial infection, virus infection, helminthiasis, etc., and the mentioned TCM whose antiapicomplexan activity have been previously reported. In conclusion, TCM possess promising activity in vivo and in vitro against T. gondii, and the components of TCM deserve further study.

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“…This drug has been used in the treatment of night sweats, deficiency of qi (e.g., fatigue, weakness, and loss of appetite) and diarrhea (Foster and Yue, 1992;Shi et al, 2011;Song et al, 2008). A. membranaceus is often harvested in autumn and dried use in decorations, powder, and tinctures.…”

Section: Introductionmentioning

confidence: 99%

Variation of Astragalosides Contents in Cultivated Astragalus membranaceus

Kim¹,

Jun²,

Lim³

et al. 2012

Korean Journal of Medicinal Crop Science

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: This study was conducted to determine the contents of astragalosides in Astragalus membranaceus. The total astragaloside content (1701 ㎍ g -1 ) of 2 year-cultivated astragalus was the highest among the variously cultivated astragalus plants. Upon an increase in cultivation time, the average value of the total astragaloside content decreased (from 1650 ㎍ g -1 to 645 ㎍ g -1 ). Especially, the content of astragaloside decreased rapidly. Comparison between the top and subterranean parts of harvested astragalus plants showed that as the cultivation time increased, the astragaloside content of the top part decreased. On the other hand, the subterranean part demonstrated the opposite pattern. The astragaloside content of the top root increased compared to that in the lateral root (from 1.9 ㎍ g -1 to 33.4 ㎍ g -1 ). Further, the content of astragaloside increased in the top root as the cultivation time increased.

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Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides

Cited by 79 publications

References 27 publications

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

Variation of Astragalosides Contents in Cultivated Astragalus membranaceus

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