Chemical components and monoamine oxidase B inhibition activities from the tubers of <i>Sauromatum giganteum</i> (Engl.) Cusimano &amp; Hett

Ayeni, Emmanuel Ayodeji; Ma, Chao; Zhang, Yongmei; Fan, Wenqin; Liao, Xun

doi:10.1080/14786419.2022.2137502

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…This is the first report on the MAO-B inhibitory activity of both compounds while supporting the ethnomedicinal claims of N. glandulifera as an anti-neurodegenerative herb and a functional food. Furthermore, previous studies report that several compounds from herbal medicines, such as caffeic acid, catechin, and esculin, possess significant MAO-B inhibitory effects [ 44 , 45 , 46 , 47 ]. Our findings support the conclusion of previous studies that medicinal plants are a rich source for discovering inhibitors of MAO-B [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity

Ayeni

Ma²,

et al. 2023

Plants

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Nigella glandulifera is a traditional medicinal plant used to treat seizures, insomnia, and mental disorders among the Tibetan and Xinjiang people of China. Recent pharmacological research indicates that the seeds of this plant have a neuroprotective effect; however, the chemical components responsible for this effect are unknown. Monoamine oxidase B (MAO-B) has been recognized as a target for developing anti-Parkinson’s disease drugs. In this work, MAO-B functionalized magnetic nanoparticles were used to enrich the enzyme’s ligands in extracts of N. glandulifera seeds for rapid screening of MAO-B inhibitors coupled with HPLC-MS. Tauroside E and thymoquinone were found to inhibit the enzyme with IC50 values of 35.85 μM and 25.54 μM, respectively. Both compounds exhibited neuroprotective effects on 6-OHDA-induced PC-12 cells by increasing the cell viability to 52% and 58%, respectively, compared to 50% of the injured cells. Finally, molecular docking indicated strong interactions of both inhibitors with the enzyme. This work shows that MAO-B functionalized magnetic nanoparticles are effective for rapid screening of anti-PD inhibitors from complex herbal mixtures and, at the same time, shows the promising potential of this plant’s seeds in developing anti-PD drugs.

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Section: Resultsmentioning

confidence: 99%

Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity

Ayeni

Ma²,

et al. 2023

Plants

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“…In this study, FZL also inhibited ISO-induced mitochondrial oxidative stress injury and apoptosis, maintained MMP, and restored mitochondrial function to play the cardiovascular protective role ( Fan et al, 2020 ). Besides, Fuzi contains bioactive components (including berberine, rutin, and 5-caffeoylquinic acid) ( Ayeni et al, 2023 ) that inhibit an enzyme, monoamine oxidase B, thereby reducing oxidative stress, improving mitochondria, and contributing to the enhancement of left ventricular function ( Kaludercic et al, 2014 ). In addition, studies in SD rats have shown that FPS exerts mitochondrial and cardiomyocyte protective effects ( Liu and Ji, 2011 ).…”

Section: The Potential Impact Of Yyfz On Mitochondria-er Interactionsmentioning

confidence: 99%

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Ding,

Ji,

Wang

et al. 2024

Front. Pharmacol.

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Cardiovascular diseases (CVD) remain the leading cause of death worldwide and represent a major public health challenge. YiyiFuzi Powder (YYFZ), composed of Coicis semen and Fuzi, is a classical traditional Chinese medicine prescription from the Synopsis of Golden Chamber dating back to the Han Dynasty. Historically, YYFZ has been used to treat various CVD, rooted in Chinese therapeutic principles. Network pharmacology analysis indicated that YYFZ may exhibit direct or indirect effects on mitochondria-endoplasmic reticulum (ER) interactions. This review, focusing on the cardiovascular protective effects of Coicis semen and Fuzi, summarizes the potential mechanisms by which YYFZ acts on mitochondria and the ER. The underlying mechanisms are associated with regulating cardiovascular risk factors (such as blood lipids and glucose), impacting mitochondrial structure and function, modulating ER stress, inhibiting oxidative stress, suppressing inflammatory responses, regulating cellular apoptosis, and maintaining calcium ion balance. The involved pathways include, but were not limited to, upregulating the IGF-1/PI3K/AKT, cAMP/PKA, eNOS/NO/cGMP/SIRT1, SIRT1/PGC-1α, Klotho/SIRT1, OXPHOS/ATP, PPARα/PGC-1α/SIRT3, AMPK/JNK, PTEN/PI3K/AKT, β2-AR/PI3K/AKT, and modified Q cycle signaling pathways. Meanwhile, the MCU, NF-κB, and JAK/STAT signaling pathways were downregulated. The PERK/eIF2α/ATF4/CHOP, PERK/SREBP-1c/FAS, IRE1, PINK1-dependent mitophagy, and AMPK/mTOR signaling pathways were bidirectionally regulated. High-quality experimental studies are needed to further elucidate the underlying mechanisms of YYFZ in CVD treatment.

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“…Interestingly, in silico and in vitro studies also revealed the MAO-B and COMT inhibitory potential of rutin (Ayeni et al, 2022;Engelbrecht et al, 2019;Mubashir et al, 2020). However, the pharmacological efficacy of rutin is reported to be lowered by the poor solubility, rapid metabolism and bioavailability of the molecule (Alshahrani, 2022;Liu, Zhao, et al, 2020).…”

Section: Berbelmentioning

confidence: 99%

“…Similarly, rutin is also found to improve motor functions, increase striatal dopamine levels, reduce oxidative stress and mitochondrial dysfunction and ameliorate dopaminergic neuron loss in cell and rat models of PD (Islam et al, 2012; Magalingam et al, 2016; Park et al, 2014). Interestingly, in silico and in vitro studies also revealed the MAO‐B and COMT inhibitory potential of rutin (Ayeni et al, 2022; Engelbrecht et al, 2019; Mubashir et al, 2020). However, the pharmacological efficacy of rutin is reported to be lowered by the poor solubility, rapid metabolism and bioavailability of the molecule (Alshahrani, 2022; Liu, Zhao, et al, 2020).…”

Section: Phyto‐compounds and Their Neuroprotective Effects In Ad And ...mentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

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Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the impairment of memory and motor functions, respectively. Despite several breakthroughs, there exists a lack of disease‐modifying treatment strategies for these diseases, as the available drugs provide symptomatic relief and bring along side effects. Bioactive compounds are reported to bear neuroprotective properties with minimal toxicity, however, a detailed elucidation of their modes of neuroprotection is lacking. The review elucidates the neuroprotective mechanism(s) of some of the major phyto‐compounds in pre‐clinical and clinical studies of AD and PD to understand their potential in combating these diseases. Curcumin, eugenol, resveratrol, baicalein, sesamol and so on have proved efficient in countering the pathological hallmarks of AD and PD. Curcumin, resveratrol, caffeine and so on have reached the clinical phases of these diseases, while aromadendrin, delphinidin, cyanidin and xanthohumol are yet to be extensively explored in pre‐clinical phases. The review highlights the need for extensive investigation of these compounds in the clinical stages of these diseases so as to utilize their disease‐modifying abilities in the real field of treatment. Moreover, poor pharmacokinetic properties of natural compounds are constraints to their therapeutic yields and this review suggests a plausible contribution of nanotechnology in overcoming these limitations.

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Chemical components and monoamine oxidase B inhibition activities from the tubers of Sauromatum giganteum (Engl.) Cusimano & Hett

Cited by 5 publications

References 37 publications

Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity

Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

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