Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes

Baptista, Edilene Bolutari; Zimmermann-Franco, Danielle Cristina; Lataliza, Alexandre Augusto Barros; Raposo, Nádia Rezende Barbosa

doi:10.1590/0037-8682-0188-2015

Cited by 32 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, this procedure was not necessary for other strains used herein because these standard strains have been investigated recently by different authors,18, 34, 44, 45 confirming the characterization of the strains.…”

Section: Discussionmentioning

confidence: 63%

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

Self Cite

View full text Add to dashboard Cite

Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a–4f) and p-hydroxybenzoic acid (9a–9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b–4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312 μg/mL). On the other hand, the amide series (9a–9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C–11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.

show abstract

Section: Discussionmentioning

confidence: 63%

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…4,28 Limonene (4.60%) was found in a similar proportion than in E. grandis; meanwhile, β-pinene (2.28%) was more abundant respect to the pure species in accordance with results previously reported. 5 The α-pinene (25.71%) is present in an intermediate concentration with respect to the parental composition. The hybridization resulted in a lack of sesquiterpenes and there was not novel biosynthesis of terpenes in the hybrid in accordance to literature.…”

Section: Resultsmentioning

confidence: 99%

“…3 Even though the essential oils from Eucalyptus have been widely studied in different species including hybrids there is a lack of information about the enantiomers proportions. [3][4][5][6][7][8] The analysis of enantiomers is an issue of interest in the study of natural products, flavors, pharmacology and organic chemistry. It is well known that both enantiomers of a same molecule may have different biological activities mainly due to differences at the molecular recognition by a protein receptor.…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric Ratio Changes of Terpenes in Essential Oils from Hybrid Eucalyptus grandis × E. tereticornis and its Pure Species

Naspi¹,

Costa²,

Lucı́a³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Some Eucalyptus species produce oils with biological activities and the effect of their interspecific hybridization on the enantiomeric composition of terpenes has not been reported. The enantiomeric excesses of monoterpenes in the essential oil of Eucalyptus grandis × E. tereticornis and its parental taxa were determined by gas chromatography-mass spectrometry (GC-MS), and to resolve coelutions problems by preparative high performance liquid chromatography (HPLC) and GC-MS with two columns in series. The essential oil composition of the hybrid presented qualitative and quantitative differences with the composition of its parental taxa. Great differences were found for the enantiomeric ratio in monoterpene alcohols among the three essential oils. Our results suggest that the enantiomeric analysis can be a reliable method for the study of how the interspecific hybridization can module the enantiomeric chemical profile in Eucalyptus essential oils. These results suggest the use of interspecific hybridization to improve or expand the source of bioactive compounds.

show abstract

“…They can be stored in canals, cavities, secretory cells or glandular ,trichomes [3]. These oils can serve in medical treatment as antimicrobial, antiviral, anticancer, antiinflammatory, antiparasitic, insecticidal, antifungal, as analgesic products and even as food preservatives as well as active ingredients in cosmetics [4][5][6][7][8][9][10][11][12][13]. As many disease causing bacteria have become multiple drug resistant, they are hardly resistible by using conventional antibiotics and as a result the morbidity and mortality rate is increasing because of infections which were once easy to treat [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Antibacterial Activity of Different Essential Oils against Different Bacteria

Akter¹,

Moumita²,

Ahmed³

2019

International Journal of Advanced Research in Computer and Comm

View full text Add to dashboard Cite

The problem caused by drug resistant pathogenic bacteria has become a common phenomenon from the last few decades. People infected with many bacteria which was once easily curable by the administration of proper antibiotics, have become difficult to eradicate due to their acquisition of antibiotic resistant trait. As a result people are dying from lack of proper medication which will be able to kill such pathogens. In search of such potent therapeutics, natural resources are targeted and essential oil is such a natural resource which can actively inhibit different pathogenic bacteria. Current study aimed in to determine the potency of tea tree essential oil, sweet orange essential oil and ylangylang essential oil against antibiotic resistant bacteria. The efficacy of the essential oils was determined against Staphylococcus aureus, Pseudomonas luteola, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus subtilis and Escherichia coli and was compared by using both micro dilution and agar well diffusion method. The highest average inhibition rate was found for tea tree essential oil (93.67%) followed by ylang-ylang (81.33%) and sweet orange essential oil (74.16%) after twenty four hours. Tea tree oil was 100% effective against all bacteria used in this experiment except Bacillus subtilis (62%). Highest percentage inhibition for ylang-ylang was against Klebsiella pneumoniae (100%). Sweet orange essential exhibited 100% inhibition for Klebsiella pneumoniae, Pseudomonas luteola and Escherichia coli. Tea tree oil has the highest ability to inhibit all of the six selected bacteria which are already resistant to antibiotics. It has been observed that multi drug resistant isolates (Escherichia coli-resistant to 4 th generation cephalosporin) is surprisingly inhibited by all of these essential oils. The antibacterial properties of these oils can be aimed to produce new therapeutics to combat the resistant bacteria.

show abstract

Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes

Cited by 32 publications

References 26 publications

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Enantiomeric Ratio Changes of Terpenes in Essential Oils from Hybrid Eucalyptus grandis × E. tereticornis and its Pure Species

Comparative Study of Antibacterial Activity of Different Essential Oils against Different Bacteria

Contact Info

Product

Resources

About