Chemical Composition and Bioctivity of the Giant Polypore or Black-Staining Mushroom, Meripilus giganteus (Agaricomycetes), from Serbia

Petrovic, Nevena; Tosti, Tomislav; Srbljak, Ivana; Đurić, Ana; Kosanić, Marijana

doi:10.1615/intjmedmushrooms.2022044119

Cited by 7 publications

(2 citation statements)

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“…On the contrary, its pharmacological potential seems to be noteworthy. Indeed, different authors demonstrated its antioxidant and antibacterial properties (Karaman et al, 2014;Petrovi c et al, 2022;Sárközy et al, 2020). Alongside these demonstrated abilities, there are some results also in support of the cancer chemopreventive potential of M. giganteus.…”

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confidence: 86%

Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?

Lenzi

Gasperini

2023

Phytotherapy Research

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To the Editor,The search for ideal cancer chemoproventive compounds, that is, effective at low doses, with little or no toxicity, easily administrable and low cost (Wang & Chen, 2013), has led to an exponential interest in non-nutritive components of natural origin, generically identifiable in the class of phytochemicals. This started a boundless research field, stimulating thousands of studies and producing numerous results in support of the cancer chemopreventive potential of different botanical species, such as Brassicaceae (Cocchi et al., 2020).Great interest has been addressed to different mushrooms species (Nowakowski et al., 2021), including those belonging to the Polyporales order (Basidiomycota philum), such as the famous Ganoderma lucidum (known as Reishi), which has been employed in Chinese and Japanese folk medicine since ancient times. The popular opinion attributes to G. lucidum almost "miraculous" properties and numerous studies are available concerning its anti-inflammatory, antioxidant, antibacterial, antiviral and neuroprotective properties (Cör Andrejč et al., 2022). In addition, cancer chemopreventive effects have been

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confidence: 86%

Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?

Lenzi

Gasperini

2023

Phytotherapy Research

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“…Evidence suggested that neuroprotective agents may be cytotoxic at high concentrations. [22][23][24][25] To further evaluate the potency and toxicity of compounds, we selected the most potent compounds 9c and 9d to test their neuroprotection capacity in high concentrations (10, 20, 50, and 100 μmol/L), using Fenazinel as the positive control group. According to the results of the MTT assay (►Fig.…”

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confidence: 99%

Design, Synthesis, and Neuroprotective Effects of Novel Cinnamamide-Piperidine and Piperazine Derivatives

Li,

Peng,

Huang

et al. 2023

Pharmaceutical Fronts

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In our previous studies, Fenazinel has shown good neuroprotective effects; however, when Fenazinel entered phase 1 clinical trials, it was associated with certain side effects. This study aimed to explore novel neuroprotective agents with higher potency and lower toxicity. Evidence suggested that cinnamic acid and its analogs may serve as promising lead compounds for stroke treatment. In this study, a series of Fenazinel derivatives were first synthesized with potential neuroprotective effects with fragments including cinnamic acid and its analogs as key functional groups. The methyl thiazolyl tetrazolium assay was performed to assess the neuroprotective effects of the compounds in glutamate-induced neurotoxicity in SH-SY5Y cells. The hERG binding assay was conducted to assess drug-induced QT prolongation or other cardiotoxicity. The neuroprotective activity of the most potent compound in vivo was tested through the survival time of mice under the hypoxic condition and a middle cerebral artery occlusion model. Our data suggested that among those derivatives, compound 9d exhibited potent neuroprotective activity in vitro comparable to Fenazinel at the test concentrations. Significantly, 9d exhibited weak hERG inhibitory activity, showing moderate activities in both hypoxia-tolerant and MCAO models in vivo. Given the above, 9d has the potential for the treatment of stroke and could be considered a lead neuroprotective agent for further development.

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Chemical Characterization and Bioactive Properties of the Edible and Medicinal Honey Mushroom Armillaria mellea (Agaricomycetes) from Serbia

Petrović

Kosanić

Tosti

et al. 2023

Int J Med Mushrooms

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Honey mushroom, Armillaria mellea, is an edible and medicinal lignicolous basidiomycete. In this study, we investigated the chemical composition and bioactive properties of its methanolic and acetonic extracts. The chemical characterization of extracts was done with the HPLC-DAD-MS/MS method. The results showed that potassium was the most abundant mineral; chlorogenic acid was the most abundant polyphenol; malic acid was the most abundant organic acid; and among carbohydrates, the most abundant were sorbitol, glucose, fructose, and saccharose. Antioxidative activity was assessed by DPPH (IC50 of the methanolic extract was 608.32 μg/mL and of the acetonic extract 595.71 μg/mL) and reducing power assays (the results ranged between 0.034 and 0.102 μg/mL). Total phenolic content was determined as gallic acid equivalent (methanolic extract: 4.74 mg GAE/g; acetonic extract: 5.68 mg GAE/g). The microdilution assay was used to evaluate the antimicrobial activity of the extracts, and the results ranged from 1.25 to 20 mg/mL. The antidiabetic effect of the extracts was tested by the α-amylase (the results ranged from 34.90% to 41.98%) and α-glucosidase assays (the results were in the range of 0.55-2.79%). The neuroprotective activity was explored by the acetylcholinesterase inhibition assay (the results were in the range of 1.94-7.76%). The microtetrazolium assay was used to investigate the cytotoxic activity of the extracts (the IC50 values ranged from 212.06 to > 400 μg/mL). Although some results suggest that some activities of the extracts are relatively moderate, the honey mushroom can still be considered an excellent source of food and bioactive compounds with medicinal value.

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Chemical Composition and Bioctivity of the Giant Polypore or Black-Staining Mushroom, Meripilus giganteus (Agaricomycetes), from Serbia

Cited by 7 publications

References 0 publications

Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?

Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?

Design, Synthesis, and Neuroprotective Effects of Novel Cinnamamide-Piperidine and Piperazine Derivatives

Chemical Characterization and Bioactive Properties of the Edible and Medicinal Honey Mushroom Armillaria mellea (Agaricomycetes) from Serbia

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