Chemical composition and biological activities of Valeriana dioscoridis SM. roots

Sen-Utsukarci, Burcu; Kessler, Sonja M.; Akbal-Dağıstan, Özlem; Estep, Alden S.; Tabanca, Nurhayat; Kürkçüoğlu, Mine; Özkan, Esra Eroğlu; Gül, Zülfiye; Bardakçı, Hilal; Becnel, James J.; Kiemer, Alexandra K.; Mat, Afife; Başer, Kemal Hüsnü Can

doi:10.1016/j.sajb.2021.05.007

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…Similar findings have been previously reported for the insecticidal activity of bornyl acetate against Ae. Aegypti and other insects [48] . These findings substantially confirmed the results of our study.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Mustapha

Algethami

Elamin

et al. 2023

Chemistry & Biodiversity

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In this work, essential oils extracted from roots and aerial parts of Inula graveolens by hydrodistillation and their fractions obtained by chromatographic simplification were first investigated for their chemical composition by GC/MS and then evaluated for the first time for their repellency and contact toxicity properties against Tribolium castaneumadults. Twenty-eight compounds were identified in roots essential oil (REO), which accounted for 97.9 % of the total oil composition, with modhephen-8-β-ol (24.7 %), cis-arteannuic alcohol (14.8 %), neryl isovalerate (10.6 %) and thymol isobutyrate (8.5 %) as major constituents. Twenty-two compounds were found in the essential oil from aerial parts (APEO), which accounted for 93.9 % of the total oil, with borneol (28.8 %), caryophylla-4(14),8(15)-dien-6-ol (11.5 %), caryophyllene oxide (10.9 %), τ-cadinol (10.5 %) and bornyl acetate (9.4 %) as main compounds.REO and APEO displayed stronger repellency after 2 h of exposure (80.0 and 90.0 %, respectively) against T. castaneum at the concentration of 0.12 μL/cm 2 . After fractionation, fractions R 4 and R 5 exhibited greater effects (83.3 % and 93.3 %, respectively) than the roots essential oil. Furthermore, the fractions AP 2 and AP 3 showed higher repellency (93.3 and 96.6 %, respectively) than the aerial parts oil. The LD 50 values of oils from roots and aerial parts topically applied were 7.44 % and 4.88 %, respectively. Results from contact toxicity assay showed that fraction R 4 was more effective than the roots oil with LD 50 value of 6.65 %. These results suggests that essential oils of roots and aerial parts from I. graveolens may be explored as potential natural repellent and contact insecticides against T. castaneum in stored products.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Mustapha

Algethami

Elamin

et al. 2023

Chemistry & Biodiversity

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“…These findings could indicate that if we want to improve the antioxidant properties of the formulation, V. officinalis and H. lupulus, could be the main players in the actions. The approach was also supported by several researchers who reported significant antioxidant properties in the plants [23][24][25][26][27][28]. In addition to the PCA analysis, Pearson's correlation between antioxidant methods and total bioactive components was calculated.…”

Section: Principal Components Analysis (Pca)mentioning

confidence: 94%

Neuromodulatory and Protective Effects Induced by the Association of Herbal Extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus with Melatonin: An Innovative Formulation for Counteracting Sleep Disorders

et al. 2022

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Background: The use of herbal extracts could represent an advantageous approach for treating sleeping disorders, especially in mild-to-moderate conditions, before the onset of a specific therapy with first-line drugs. Specifically, the focus was posed about the use of extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus. Multiple studies demonstrated the efficacy of these medicinal plants to positively manage insomnia symptoms. Additionally, their efficacy in the treatment of sleeping disorders could also be improved by their pharmacological association. In the present study, extracts from Valeriana officinalis, Ziziphus jujuba, Humulus lupulus, melatonin, and their pharmacological association, Vagonotte® MEL, were studied for potential application in the treatment of insomnia. Methods: The extracts and melatonin were tested on hypothalamic neurons and tissue for evaluating biocompatibility and protective and neuromodulatory effects. The neuromodulatory effects were evaluated as orexin A gene expression and serotonin steady state level, in the hypothalamus. Results: The extracts and melatonin, although with evident differences, were effective as antioxidant and anti-inflammatory agents; additionally, they were also able to reduce the hypothalamic gene expression of orexin A and the steady state level of serotonin, playing master roles in wakefulness. It is noteworthy that the formulation displayed all the effects of the single ingredients, without any sign of toxicity and pharmacological interference in the hypothalamus. Conclusions: Concluding, the present study explored the biological effects of melatonin and herbal extracts with phytotherapy interest in V. officinalis, Z. jujuba, and H. lupulus. The study demonstrated their intrinsic scavenging/reducing activity, together with protective and neuromodulatory effects in the hypothalamus, with a significant reduction of both orexin A gene expression and serotonin steady state level. Additionally, the study also considered their pharmacological association, which displayed an overall pharmacological spectrum mirroring, including all the effects of the single ingredients, without showing any sign of toxicity in the brain and interference between the extracts and melatonin.

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The insecticidal activities of Erica manipuliflora Salisb. Extracts in the flowering and fruiting periods and their evaluation in term of chemical profiles of active extracts

Şen¹,

Gürdal²,

Estep³

et al. 2022

Industrial Crops and Products

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Chemical composition and biological activities of Valeriana dioscoridis SM. roots

Cited by 4 publications

References 47 publications

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Neuromodulatory and Protective Effects Induced by the Association of Herbal Extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus with Melatonin: An Innovative Formulation for Counteracting Sleep Disorders

The insecticidal activities of Erica manipuliflora Salisb. Extracts in the flowering and fruiting periods and their evaluation in term of chemical profiles of active extracts

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