Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam

Abstract

Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (1), 3-indolecarbaldehyde (2), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3), 2-[(2R-hydroxypropanoyl)amino]benzamide (4), 4-hydroxybenzandehyde (5), chrysogine (6), 3-acetyl-4-hydroxycinnoline (7), acid 1H-indole-3-acetic (8), cyclo (Tyr-Trp) (9), and 2’,3’-dihydrosorbicillin (10). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3) showed a strong inhibitory effect against Enterococcus faecalis with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2R-hydroxypropanoyl)amino]benzamide (4) and 4-hydroxybenzandehyde (5) selectively inhibited E. coli with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (10) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).

Diversity and assembly patterns of mangrove rhizosphere mycobiome along the Coast of Gazi Bay and Mida Creek in Kenya

“…The differential abundance of Hypoxylon in the anthropogenically disturbed Mida creek is not surprising as some species of these genera are important plant symbionts and produce organic compounds that are active against several plant pathogens, including Botrytis cinerea , Phytophthora cinnamomi and Cercospora beticola [ 57 ]. Similarly, several species of Penicillium isolated from mangroves are important source of bioactive materials that are inhibitory to microbial pathogens [ 58 ]. Thus, the observed differential abundance of these genera in Mida creek is likely to support plant stability in response to environmental changes resulting from human disturbance.…”

Penicillium vietnamensesp. nov., the First Novel Marine Fungi Species Described from Vietnam with a Unique Conidiophore Structure and Molecular Phylogeny ofPenicilliumSectionCharlesia

“…The strain DW14M has shown an ability to degrade protein with moderate protease activity but no activities of amylase, phytase, cellulase, and chitinase were monitored (data not shown). Other Penicillium isolates from marine sediments collected in Vietnam were found to express diverse secondary metabolites [ 44 ], thus novel species become an invaluable source of novel active secondary metabolites possessing various biological activities. In addition, along with Candida , Aspergillus , and Cladosporium , Penicillium was among the most dominant genera in both surface coastal marine and deeper waters at Nha Trang Bay, which suggested the contribution of marine saprotrophic ascomycetes fungi to the degradation of organic materials in marine ecosystems [ 11 ].…”

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

“…Compound 46 showed a strong inhibitory effect against Enterococcus faecalis , whereas both 47 and 48 selectively inhibited Escherichia coli . Moreover, 2′,3′-dihydrosorbicillin ( 49 ) potentially inhibited α-glucosidase activity [ 38 ].…”

“… Donghae-si, Gangwon-do, South Korea, The Japanese Sea Antibacterial (Kocuria rhizophila and SA) [ 37 ] Mycousfuran B ( 45 ) 2-[(5-Methyl-1,4-dioxan-2-yl)methoxy]ethanol ( 46 ) Penicillium sp. M30 Con Co Island, The South China Sea Antibacterial (Enterococcus faecalis) [ 38 ] 2-[(2R-Hydroxypropanoyl)amino]benzamide ( 47 ) Antibacterial (E. coli) 4-Hydroxybenzandehyde ( 48 ) 2′,3′-Dihydrosorbicillin ( 49 ) Inhibition of α-glucosidase activity Penicacid D ( 50 ) Penicillium sp. SCSIO sof101 The South China Sea Antibacterial (E. coli and Acinetobacter baumannii) [ 39 ] Purpuride D ( 51 ) Penicillum sp.…”