Chemical composition and biological activity of aerial parts of Salvia verticillata L. growing in Georgia

Abstract

A study of the chemical composition of the essential oil obtained from the aerial parts of Salvia verticillata L., growing in Georgia, was carried out. The percentage of dominant components was determined by internal integration, the dominant component in the essential oil obtained from the leaves is caryophyllene (10.15 %), spathulenol (9.8 %), valeranone (11.9 %), and in the essential oil obtained from the flowers, germacrene D (17.2 %), caryophyllene (9.43 %). The ratio of terpene compounds was determined in the leaves and flowers of Salvia verticillata L., oxygenated sesquiterpenes are 38.43 % and 23.48 % respectively, and sesquiterpene hydrocarbons are 28.03 % and 40.61 %. The content of phenolic compounds was determined using Folin-Ciocalteu reagent in the aqueous, methanol and chloroform fractions of the residual plant material. The methanolic and chloroform fractions showed anti-inflammatory activity, the methanolic fraction -100 % and the chloroform fraction -83 % inhibiting the production of NO from lipopolysaccharide-stimulated mouse macrophage cells (RAW264.7). The aqueous fraction showed antioxidant activity (6.7 ± 0.3 micromole TE/mg) in the ORAC test.