Chemical Composition and <i>in Vitro</i> Antibacterial Activity of the Essential Oil of <i>Minthostachys Mollis</i> (Kunth) Griseb Vaught from the Venezuelan Andes

Mora, Flor; Araque, Marı́a; Rojas, Luis; Ramírez, Rosslyn N.; Silva, Bladimiro; Usubillaga, Alfredo

doi:10.1177/1934578x0900400726

Cited by 13 publications

(22 citation statements)

References 10 publications

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“…Is known by various popular names and has di erent medicinal uses. In Venezuela, M. mollis is known as oreganote and is prepared as tea and used to treat infectious diseases of children, as well as for rheumatism [2]. In Peru, the most well-known name of M. mollis is "muña", but in some regions it is also known as "ishmuña", "tento", "tinto" and "champca"; Traditionally it is used for the treatment of cough, bronchitis, stomach ulcer, gastritis, stomach and intestinal spasm, cold, headache, intestinal parasitism and as digestive [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Rojas-Armas

Arroyo-Acevedo

Ortiz-Sánchez

et al. 2019

Journal of Toxicology

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Medicinal plants are used throughout the world and the World Health Organization supports its use by recommending quality, safety and efficacy. Minthostachys mollis is distributed in the Andes of South America and is used by the population for various diseases. While studies have shown their pharmacological properties, the information about their safety is very limited. Then, the goal of this research was to determine the acute oral toxicity and in repeated doses during 28 days of Minthostachys mollis essential oil (Mm-EO) in rats. For the acute toxicity test two groups of rats, of three animals each, were used. Each group received Mm-EO in a single dose of 2000 or 300 mg/kg of body weight. For the repeated dose toxicity test, four groups of 10 rats each were used. Doses of 100, 250 and 500 mg/kg/day were used, one group was control. With the single dose of Mm-EO of 2000 mg/kg of body weight, the three rats in the group showed immediate signs of toxicity and died between 36 and 72 hours. In the lung, inflammatory infiltrate was observed, predominantly lymphocytic with severe hemorrhage and presence of macrophages with hemosiderin. In the repeated dose study, male rats (5/5) and female rats (2/5) died at the dose of 500 mg/kg/day. The body weight of both male and female rats decreased significantly with doses of 250 and 500 mg/kg/day. The serum levels of AST and ALT increased significantly and the histopathological study revealed chronic and acute inflammatory infiltrate in the lung; while in the liver was observed in 80% of the cases (24/30) mild chronic inflammatory infiltrate and in some of those cases there was vascular congestion and in one case cytoplasmic vacuolization. The Mm-EO presented moderate acute oral toxicity, while with repeated doses for 28 days; there was evidence of toxicity, in a dose-dependent manner, mainly at the hepatic level.

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Section: Introductionmentioning

confidence: 99%

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Rojas-Armas

Arroyo-Acevedo

Ortiz-Sánchez

et al. 2019

Journal of Toxicology

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“…Other traditional uses of Minthostachys include biopesticides (antimycotic and antiparasitic, against flea infestations) and for the protection of stored potato and oca tubers from aphids and pests [6,7]. In recent years, there have been numerous research studies on Minthostachys oils to provide scientific evidences on their medicinal properties [8][9][10][11]. For instance, the main components of Minthostachys verticillata (M. verticillata) essential oil, namely pulegone (63.4%), menthone (15.9%), and limonene (2.1%), have been linked immediate-type allergic reactions in vitro and in vivo [8].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the main components of Minthostachys verticillata (M. verticillata) essential oil, namely pulegone (63.4%), menthone (15.9%), and limonene (2.1%), have been linked immediate-type allergic reactions in vitro and in vivo [8]. Montironi et al (2016) have shown the bactericidal efficacy of M. verticillata essential oil against Streptococcus uberis strains isolated from bovine mastitis [9], while the essential oil of Minthostachys mollis (M. mollis) that largely contained pulegone (55.2%) and trans-menthone (31.5%) showed significant efficacy against Gram-positive and Gram-negative bacteria, especially Bacillus subtilis and Salmonella typhi, at 4 µg/mL [10]. A natural product, (−)-(1S,2R,3R,4S)-1,2-epoxy-1-methyl-4-(1-methylethyl)-cyclohex-3-yl acetate, isolated from the volatile constituents of Minthostachys tomentosa exhibited significant insecticidal activity against Oncopeltus fasciatus, whereas its synthetic form was found inactive [11].…”

Section: Introductionmentioning

confidence: 99%

“…Although the Minthostachys genus has received growing attention from modern pharmacology and medicine, the interest in this genus has been concentrated only on few species, mainly M. verticillata, M. mollis, Minthostachys andina or Minthostachys glabrescens, whereas very few studies have been focused on Minthostachys diffusa (M. diffusa) Epling [6][7][8][9][10][11]. M. diffusa is also known as "tusuwaya", an endemic species prevalent in Bolivia, where the local population uses its aerial part as tea and to treat digestive, spasms and carminative disorders [6], but its properties and phytochemical composition have not been explored yet.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemicals of Minthostachys diffusa Epling and Their Health-Promoting Bioactivities

Faraone

Russo

Chiummiento

et al. 2020

Foods

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The genus Minthostachys belonging to the Lamiaceae family, and is an important South American mint genus used commonly in folk medicine as an aroma in cooking. The phytochemical-rich samples of the aerial parts of Minthostachys diffusa Epling. were tested for pharmacological and health-promoting bioactivities using in vitro chemical and enzymatic assays. A range of radical scavenging activities of the samples against biological radicals such as nitric oxide and superoxide anion and against synthetic 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, the ferric reducing antioxidant power and the lipid peroxidation inhibition were determined and ranked using the ‘relative antioxidant capacity index’ (RACI). The ethyl acetate fraction showed the highest RACI of +1.12. Analysis of the various fractions’ inhibitory ability against enzymes involved in diabetes (α-amylase and α-glucosidase), and against enzymes associated with Parkinson’s or Alzheimer’s diseases (acetylcholinesterase and butyrylcholinesterase) also suggested that the ethyl acetate fraction was the most active. Liquid chromatography–tandem mass spectrometry analysis of the ethyl acetate fraction showed more than 30 polyphenolic compounds, including triterpenes. The inhibitory cholinesterase effects of the triterpenes identified from M. diffusa were further analysed by in silico docking of these compounds into 3D-structures of acetylcholinesterase and butyrylcholinesterase. This is the first study on pharmacological activities and phytochemical profiling of the aerial parts of M. diffusa, showing that this plant, normally used as food in South America, is also rich in health-promoting phytochemicals.

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“…Pharmacopoeia, 2009;European Pharmacopoeia, 2007) (PRIMO et al, 2001). O óleo de M. mollis apresentou teores de pulegona e mentona de 55,2 e 31,5 %, respectivamente (MORA et al, 2009). Estes resultados confirmam outras pesquisas, que demonstraram que os terpenos são responsáveis pela atividade antibacteriana e antifúngica (KARAMAN et al, 2003;SAHIN, 2002;GULLUCE et al, 2007).…”

Section: Obtenção Do óLeo Essencialunclassified

Avaliação da atividade antimicrobiana do óleo essencial e do extrato de >I<Minthostachys>/I< setosa (Briq.) Epling

Pinto¹

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mestrado e pelo apoio financeiro para a realização desta pesquisa. À Professora Terezinha pelas palavras e exemplo de carinho e força para continuar no desenvolvimento do meu trabalho. Ao Professor Paulo Moreno que contribuiu na realização da cromatografia do óleo essencial da planta e enriqueceu minha formação com seus conhecimentos. À Professora Edna Tomiko Kato pela contribuição no desenvolvimento do meu trabalho. Ao Biólogo Justo Mantilla pela contribuição no processo de extração do óleo essencial da planta.

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Chemical Composition and in Vitro Antibacterial Activity of the Essential Oil of Minthostachys Mollis (Kunth) Griseb Vaught from the Venezuelan Andes

Cited by 13 publications

References 10 publications

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Phytochemicals of Minthostachys diffusa Epling and Their Health-Promoting Bioactivities

Avaliação da atividade antimicrobiana do óleo essencial e do extrato de >I<Minthostachys>/I< setosa (Briq.) Epling

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