Chemical Composition, Anti-bacterial Activity and Molecular Docking Studies of Essential Oil Isolated from Sa Sam Nam (&lt;i&gt;Launaea sarmentosa&lt;/i&gt;)

Pham, Ty Viet; Hoang, Thao Xuan; Nguyen, Hoai-Nguyen; Do, Bich Hang; Vo, Huy-Hoang Nguyen; Tran, Gia-Buu

doi:10.5650/jos.ess23254

J. Oleo Sci.

2024

DOI: 10.5650/jos.ess23254

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Chemical Composition, Anti-bacterial Activity and Molecular Docking Studies of Essential Oil Isolated from Sa Sam Nam (Launaea sarmentosa)

Ty Viet Pham,

Thao Xuan Hoang,

Hoai-Nguyen Nguyen

et al.

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2024

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Cited by 2 publications

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Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

Pham,

Hoang,

et al. 2024

Chemistry & Biodiversity

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Three species of the Rutaceae family, including Acronychia pedunculata, Euodia lepta, and Severinia monophylla have been used in traditional medicine. However, the comparison of the chemical composition, anti‐cancer, and anti‐inflammatory effects of the leaf essential oils of these species have not been investigated yet. A total of 38 compounds were identified via gas chromatography‐mass spectrometry, comprising 96.5–99.8 % of the total composition. Both A. pedunculata and E. lepta essential oils exhibited strong inhibitory effects against cancer cells (IC50: 59.04–97.52 μg/mL) while that of S. monophylla showed a lower anti‐cancer effect (IC50>100 μg/mL). Among three essential oils, only the E. lepta leaf oil demonstrated a high anti‐inflammatory effect on LPS‐stimulated macrophages (IC50=6.47±0.65 μg/mL), while the others showed a moderate anti‐inflammatory effect (IC50>50 μg/mL). Molecular docking studies also suggested the binding potential of the key compounds from three essential oils against inducible nitric oxide synthase and cyclooxygenase‐2, two proteins associated with inflammatory response, with the negative energies ranging from −41.0 to −71.9 kcal/mol. The present findings suggest the leaf essential oils from these species as potential medicines for treatment of cancer or inflammation associated diseases, especially the ones from A. pedunculata and E. lepta oils.

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Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

Pham,

Hoang,

et al. 2024

Chemistry & Biodiversity

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The Anti-inflammatory Effect and Molecular Docking of Essential Oils Extracted from Rhizomes of Distichochlamys benenica and Distichochlamys citrea

Tran,

Pham,

Turkmen

et al. 2024

J. Oleo Sci.

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Chemical Composition, Anti-bacterial Activity and Molecular Docking Studies of Essential Oil Isolated from Sa Sam Nam (<i>Launaea sarmentosa</i>)

Cited by 2 publications

References 17 publications

Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

The Anti-inflammatory Effect and Molecular Docking of Essential Oils Extracted from Rhizomes of <i>Distichochlamys benenica</i> and <i>Distichochlamys citrea</i>

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