Chemical composition, antibacterial, antioxidant and cytotoxic evaluation of the essential oil from pistachio (Pistacia khinjuk) hull

Taghizadeh, Seyedeh Faezeh; Davarynejad, Gholam Hossein; Asili, Javad; Riahi-Zanjani, Bamdad; Nemati, Seyed Hossein; Karimi, Gholamreza

doi:10.1016/j.micpath.2018.08.039

Cited by 30 publications

(14 citation statements)

References 36 publications

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“…Recent studies emphasized other properties such as antioxidant, antimicrobial, antidiabetic, and antitumor activities [7,57,69,71]. Several studies have been devoted to the effects of bioactives from Pistacia species, including Atlas Pistachio, including gastroprotective and anti-H. pylori activities [4,60]. Pourya et al [14] found that the essential oil of P. atlantica can be used as a fumigant and repellent due to contact toxicity against C. maculatus.…”

Section: Resultsmentioning

confidence: 99%

Pistacia Atlantica Desf., a Source of Healthy Vegetable Oil

et al. 2019

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Pistacia atlantica, which belongs to the Anacardiaceae family, is an important species for rural people in arid and semi-arid areas. The fruit, rich in oil, is used in traditional medicine for the treatment of various diseases. The oil extracted from this species growing in a northern area of Algeria and its fatty acid composition were previously studied. However, the largest areas where this species is present (traditional cultivation) is located in southern Algeria. Moreover, studies on oil fatty acid composition and essential oil were always conducted separately. This study was performed in order to assess the fatty acid and volatile organic compound composition of P. atlantica vegetable oil. The seeds were collected randomly from Djelfa (300 km South of Algiers, Algeria). Oil content and fatty acid composition were determined by Soxhlet extraction. The seeds contained high concentrations of oil (32–67%). The major fatty acids were oleic (39–49%), linoleic (23.6–31%), and palmitic (21.3–26.6%) acids. The ratio of polyunsaturated fatty acids (PUFA) to saturated fatty acids (SFA) indicated that the content of unsaturated fatty acids was approximately three times higher than that of SFA. This ratio is widely used in epidemiological studies and research on cardiovascular diseases, diabetes, and metabolic syndrome. The ratios of -acids, i.e., -9/-6 and -6/-3, were 1.3–2 and 18.5–38.3, respectively. Crushed seeds were analyzed by headspace solid-phase microextraction (SPME) coupled with gas chromatography–mass spectrometry. More than 40 compounds were identified, mainly monoterpenes (C10H16), such as α-terpinene and terpinolene, but also sesquiterpenes (C15H24) at lower levels. The value of this species as a source of healthy oil rich in -3 acid and its effects on cardiovascular disease risk are discussed.

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Section: Resultsmentioning

confidence: 99%

Pistacia Atlantica Desf., a Source of Healthy Vegetable Oil

et al. 2019

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“…The antiviral effect curve plotted via VI (%) against peptide fractions levels. The Selectivity Index (SI) was defined as follows (Taghizadeh et al., 2018).

SI = \frac{CC 50}{IC 50}

…”

Section: Methodsmentioning

confidence: 99%

Therapeutic peptides of Mucuna pruriens L.: Anti‐genotoxic molecules against human hepatocellular carcinoma and hepatitis C virus

Taghizadeh

Azizi

Asili

et al. 2021

Food Science & Nutrition

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To assist the development of new therapeutic strategies for several disorders, biologically active peptides/proteins obtained from plant sources can be considered. Current study expected to determine the biological activities of peptide fractions of Mucuna pruriens against hepatocellular carcinoma cell lines (HepG2/ADM, HepG2, SMMC‐7721, and QGY‐7703), as well as normal cell line to prove their selectivity. Moreover, anti‐genotoxicity and antiviral activity against the hepatitis C virus (HCV) were assessed. The methods of this study were to isolate the peptides of M. pruriens and hydrolysate fractionation via fractionated pepsin‐pancreatin hydrolysates by ultrafiltration/high‐performance ultrafiltration cell, identify anti‐hepatoma activity of peptide fractions human liver cancer and normal cells by (3‐(4,5‐dimethylthiazole‐2‐yl)‐2,5‐biphenyl tetrazolium bromide) (MTT) assay, determine anti‐HCV, and assess anti‐genotoxic effect of peptide fractions against damage that induced via alkylating agent methyl methanesulphonate in human mononuclear cells. The results showed that the fraction 5–10 kDa has been reported to exhibit significant cytotoxic activity against HepG2 and QGY‐7703. It was proven that both of 5–10 and >10 kDa fractions are active against HCV. The cytotoxic concentration (CC50) of 5–10 kDa against the cell line was 703.04 ± 5.21 µg/ml. Anti‐genotoxic activities of the peptide fractions were evaluated as mean values for the analyzed comet images. In this regard, the highest activity of protecting DNA damages was observed by the peptide fraction of 5–10 kDa. This study revealed the potential ability of peptide fractions of M. pruriens for the treatment of liver cancer, HCV, and high activities of protecting DNA damages.

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“…These active compounds could enhance the antibacterial property of trans-piperitol. It was found that the mode of action of P. dhana oil could depend on the hydrophobicity of their functional groups, which enables them to partition the lipids of the bacterial cell membrane disturbing the cell wall and the cytoplasmic membrane, leading to lysis and leakage of intracellular compounds 33 . In addition, Moleyar and Narasimtram 34 described that the antimicrobial activity of volatile compounds in essential oil resulted from the combined effect of direct and indirect vapor absorption on pathogenic strains through the aqueous medium.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Chemical Composition and Biological Activity of Peucedanum Dhana A. Ham Essential Oil

Khruengsai

Sripa

Rujanapun

et al. 2020

Preprint

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The essential oil of Peucedanum dhana A. Ham growing in Thailand was investigated for their volatile compounds and screened for its antimicrobial, antioxidant, and cytotoxic activities. Forty-two compounds were identified, with the most important compounds being trans-piperitol, o-cymene, β-pinene, γ-terpinene, and limonene. Essential oil of P. dhana has remarkable antimicrobial activity against tested pathogens with minimum inhibitory concentration and minimum microbicidal concentration values, ranging from 62.50–250 µg/mL and 250-1,000 µg/mL, respectively. The antioxidant activity of P. dhana oil was measured using DPPH and ABTS scavenging activity assays. The IC50 values using the DPPH and ABTS method were 9.13 and 9.36 mg/mL, respectively. The total phenolic compounds in P. dhana oil was 183.05 mg GAE/100 g dry weight. The cytotoxic effect of P. dhana oil was tested against Hela, A549, SW480, and 3T3L1 cells. The essential oil had cytotoxicity against all cancer cells, with significant cytotoxicity towards the SW480 cell. The results indicate that the P. dhana essential oil could be used as a source of functional ingredients in food and pharmaceutical applications.

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Chemical composition, antibacterial, antioxidant and cytotoxic evaluation of the essential oil from pistachio (Pistacia khinjuk) hull

Cited by 30 publications

References 36 publications

Pistacia Atlantica Desf., a Source of Healthy Vegetable Oil

Pistacia Atlantica Desf., a Source of Healthy Vegetable Oil

Therapeutic peptides of Mucuna pruriens L.: Anti‐genotoxic molecules against human hepatocellular carcinoma and hepatitis C virus

Chemical Composition and Biological Activity of Peucedanum Dhana A. Ham Essential Oil

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