Chemical composition, antimicrobial, antioxidant and anticancer activities of essential oil from Ammodaucus leucotrichus Cosson &amp; Durieu (Apiaceae) growing in South Algeria

Benchikha, Naima; Rebiai, Abdelkrim; Ouarda, B.; Salah, N; Larbi, Ben Amor M.

doi:10.4314/bcse.v33i3.14

Cited by 16 publications

(8 citation statements)

References 14 publications

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“…Essential oils found in the plants from the Apiaceae family, especially monoterpenes, have high antioxidant capacity, which was confirmed in numerous studies [19][20][21][22]. Their properties are associated with reduced oxidative stress due to scavenging free radicals.…”

Section: Discussionmentioning

confidence: 75%

Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

et al. 2021

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Aegopodium podagraria L. (goutweed), a member of the Apiaceae family, is a common perennial plant found all around the world that has been used in folk medicine since antiquity. Goutweed leaves contain polyacetylenes, essential oils, mono- and sesquiterpenes, vitamins, macro- and microelements, and phenolic compounds. In spite of its many health-promoting properties, including antioxidant effects, the plant has not been thoroughly studied. The aim of this study was to investigate the antioxidant properties of different goutweed leaf extracts and their effects on the THP-1 cell line, and also to describe the chemical characteristics of goutweed. Falcarinol and falcarindiol and essential oil were determined by gas chromatography coupled with mass spectrometry. Spectrophotometry was used to measure the total content of polyphenols and antioxidant activity–by DPPH and FRAP methods. Oxidative stress in THP-1 cells was induced via sodium fluoride. Then, goutweed leaf extracts were added to evaluate their influence on antioxidant potential (ABTS) and the activity of antioxidant enzymes. Confocal microscopy was used to visualise the production of cytoplasmic and mitochondrial reactive oxygen species (ROS) and for in vitro imaging of apoptosis. The ethanol extracts have a high total content of polyphenols, polyacetylenes, and essential oil, as well as high antioxidant potential. The main volatiles represented diverse chemical groups, which are both oxygenated derivatives of sesquiterpenes and monoterpenes. We also demonstrated positive effects of the high antioxidant potential and increased activity of antioxidant enzymes on cell cultures under severe fluoride-induced oxidative stress. Extraction at 80 ℃ and the use of ethanol as a solvent increased the antioxidant capacity of the extract. The leaves of Aegopodium podagraria may serve as a valuable source of antioxidants in the daily diet and assist in the prevention and treatment of oxidative stress-mediated conditions, e.g., inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, and even obesity.

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Section: Discussionmentioning

confidence: 75%

Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

et al. 2021

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“…Swings Rutaceae D-limonene, pinene, camphene, bergapten Ocimum basilicum L Lamiaceae Labiatae estragole, linalool, 1,8-cineole Curcuma longa L Zingiberaceae turmerone, aromatic (ar-) turmerone Rosa damascena Rosaceae SW742 IC 50 = 10 μg/mL ↓Cell proliferation not available [ 39 ] Pistacia atlantica Anacardiaceae Caco-2 HCT116 IC 50 = 62.85 μg/mL IC 50 = 34.97 μg/mL Not available α-pinene, sabinene, limonene, terpinene-4-ol, β-pinene [ 73 ] Phoebe bournei (Hemsl.) Laureaceae SW480 IC 50 = 41.3 l μg/mL Not available α-copaene, α-muurolene, δ-cadinene, 1 s-calamenene [ 74 ] Ammodaucus leucotrichus Cosson & Durieu Apiaceae HCT116 IC 50 = 41.3 l μg/mL Not available perillaldehyde, D- limonene α-pinene [ 75 ] Inula graveolens (Linnaeus) Desf Linnaeus HT29 IC 50 = 24.6 μg/mL Not available bornyl acetate, corneol caryophyllene oxide δ-cadinol, camphene [ 76 ] Ocimum viride Lamiaceae Labiatae …”

Section: Anticancer Mechanisms Of Eos: Molecular Evidence From Precli...mentioning

confidence: 99%

Natural essential oils as a new therapeutic tool in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.

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“…Plants. In this study, the 39 identified plants against cancer have been pharmacologically validated through in vitro and in vivo studies [16,[60][61][62][63][64][65]. In Table 4, we listed the mechanisms of anticancer properties of the inventoried plants used traditionally against cancer by the studied population.…”

Section: Scientific Evidence and Mechanisms Of Action Of Anticancer M...mentioning

confidence: 99%

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Benkhaira

Ferioun

Kandsi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cancer is one of the major medical challenges, with an unacceptably high death toll worldwide. In Morocco, medicinal plants continue to play a pivotal therapeutic role despite the development of modern sanitation systems. In the current study, an ethnobotanical survey was carried out at the Moroccan national institute of oncology, Rabat, and we aimed at (1) establishing an exhaustive inventory of indigenous knowledge of Moroccan medicinal plants used to manage cancer and (2) confirming the reported ethnopharmacological uses through bibliometric review. An ethnobotanical survey was conducted with 291 cancer patients at the Moroccan National Institute of Oncology, Rabat, during a period of 4 months, from February to May 2019, through semistructured interviews. Ethnobotanical indices, including informant consensus factor (FIC), use report (UR), relative frequency citation (RFC), botanical family use value (FUV), fidelity level (FL), and index of agreement on remedies (IAR), were employed in data analyses. The survey revealed that 39 medicinal plants belonging to 27 botanical families and 38 genera were used to treat cancer. The most used ethnospecies were Aristolochia longa with the highest RFC value (0.096), followed by Nigella sativa, Ephedra alata, Euphorbia resinifera, and Lavandula dentata, éwith RFC values of 0.072, 0.054, 0.044, and 0.044, respectively. In regard to the plant families, Lamiaceae contributed the highest number of plants with five species (FUV = 0.034), followed by Asteraceae (4 species; FUV = 0.020), and Fabaceae (4 species; FUV = 0.020). The leaves are the most popular plant part used by the studied population against cancer; otherwise, decoction was the most commonly used method for remedy preparation and the highest FIC was noticed for uterine cancer treatment (0.86). Considering these findings, further investigations into the recorded plant species should be performed to assess phytochemical constituents and pharmaceutical benefits in order to identify their active compounds for any drug formulations.

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Chemical composition, antimicrobial, antioxidant and anticancer activities of essential oil from Ammodaucus leucotrichus Cosson & Durieu (Apiaceae) growing in South Algeria

Cited by 16 publications

References 14 publications

Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

Natural essential oils as a new therapeutic tool in colorectal cancer

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

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