Chemical Composition, Antioxidant and Anticholinesterase Activities of the Essential oil of Origanum rotundifolium Boiss. from Turkey

Abstract

Abstract:The essential oil was obtained by hydrodistillation from the aerial parts of Origanum rotundifolium Boiss. Its chemical content and composition were analyzed by using a gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Total phenolic content of the essential oil was determined as 132.39 µg gallic acid equivalent by Folin-Ciocalteu's method and the major component was identified as carvacrol (56.8 %) along with p-cymene (13.1 %), (Z)--ocimene (5.4 %), -caryophyllene (3.9 %), borneol (3.4 %) and thymol (3.2 %). After chemical characterization, the essential oil was evaluated for its antioxidant activity by DPPH free radical, superoxide anion radical and hydrogen peroxide scavenging activities as well as ferrous ion-chelating power test, ABTS radical cation decolorization assay and ferric thiocyanate methods. Besides antioxidant activity, acetylcholinesterase and butyrylcholinesterase inhibitory activities of the essential oil were also evaluated by Ellman's method. It demonstrated inhibitory activities on AChE and BuChE, key enzymes in the pathogenesis of Alzheimer's disease (AD), in addition to significant antioxidant activity.

Essential Oils Extracted from Different Species of the Lamiaceae Plant Family as Prospective Bioagents against Several Detrimental Pests

“…Furthermore, according to recent findings, different physiological and behavioral modes of action of essential oils and their components have been reported. For example, inhibition of adenosine triphosphatases (ATPases), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) [76,96], and distribution in the octopamine and gamma-aminobutyric acid receptors (GABArs) have been documented [112]. Given that octopamine receptors are invertebrates-specific, the use of essential oils in pest management, with this mode of action, can be considered to be safe bioagents for mammals [112].…”

The Protective Effect of Antarctic Krill Oil on Cognitive Function by Inhibiting Oxidative Stress in the Brain of Senescence‐Accelerated Prone Mouse Strain 8 (SAMP8) Mice

“…Many studies have confirmed that natural food ingredients and their products have potent neuroprotective effects (Liao et al., ; Oboh et al., ; Zhang, Luab, & Jianga, ). Recently, an increasing number of researches have become interested in identifying neuroprotective factors from natural materials, expecting to find a lot of novel neuroprotective ingredients (Özbek et al., ).…”

Antioxidant Activity of Flaxseed (Linum usitatissimum L.) shell and Analysis of Its Polyphenol Contents by LC-MS/MS

“…Total phenolics in AEF and EEF were measured by Folin-Ciocalteu reagent [4][5][6] and calculated as μg of GA equivalents (GAE) per one mg of dried extract. Total flavonoids in AEF and EEF were estimated using the AlCl 3 [9]. They were calculated as μg of quercetin equivalents (QE) per one mg dried extract.…”