Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth

Krupashree, K.; Kumar, K. Hemanth; Rachitha, P.; Jayashree, G.V.; Khanum, Farhath

doi:10.1016/j.sajb.2014.07.001

Cited by 37 publications

(27 citation statements)

References 31 publications

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“…Herbal extracts can restore the DNA when it in the Fenton state and protect the DNA damage from the radicals. 65 , 66 The observed results corroborate with our recent study which demonstrated that Picrorhiza kurroa inhibits AAPH induced DNA damage. 65 Major molecular mechanisms, leading to structural changes in proteins are free-radical mediated protein oxidation characterized by carbonyl formation.…”

Section: Discussionsupporting

confidence: 91%

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Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis

Rachitha

Krupashree

Jayashree

et al. 2018

Journal of Traditional and Complementary Medicine

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Herbal medicines are known to mitigate radical induced cell damage. Hence identification and scientific validation of herbal medicines contribute to better use in Ayurvedic/Unani research. In the present study, we investigated antioxidant and anti-apoptotic properties of Convolvulus pluricaulis (C. pluricaulis). C. pluricaulis exhibited antioxidant potential evident by free radical scavenging activities. C. pluricaulis pretreatment inhibited H2O2 induced macromolecule damage such as plasmid DNA damage and AAPH induced oxidation of bovine serum albumin and lipid peroxidation of rat hepatic tissues. Further to identify the neuroprotective properties of C. pluricaulis, SHSY5Y cells were treated with H2O2 with or without pretreatment of C. pluricaulis. The C. pluricaulis pretreatment at 50 μg/ml dose exhibited 50% cell survival against 100 μM H2O2 challenge for 24 h and it also decreased the lactate dehydrogenase leakage. Further C. pluricaulis pretreatment restored and regulated the antioxidant and apoptosis markers such as SOD, CAT, p53, and caspase-3 and inhibited, reactive oxygen species generation and depolarization of the mitochondrial membrane. C. pluricaulis possess a high content of flavonoids and polyphenols and GC-MS and FTIR analysis showed a wide variety of compounds which may contribute to the observed effects.

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Section: Discussionsupporting

confidence: 91%

“…This oxidation of protein and lipid peroxidation can be protected by several herbal plants. 65 , 67 Treatment with C. pluricaulis also showed the protective effect induced by H 2 O 2 and which is compared to control it was significantly decreased the oxidative damage.…”

Section: Discussionmentioning

confidence: 82%

Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis

Rachitha

Krupashree

Jayashree

et al. 2018

Journal of Traditional and Complementary Medicine

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“…The flavonoid apocynin is one of the active component of P. kurroa and has been noted to attenuate Parkinson's, ischemia-reperfusion and hypoxia by arresting NADH oxidase expression during oxidative stress. [12,25,26,27].Hence the present study is to investigate the P. kurroa protective effects against Fb1 induced hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Hence Fb1 is more toxic and abundant fumonisins causes liver damage in many animals [11]. P. kurroa has many medicinal benefits such as anti-allergic, anti-neoplastic immunomodulatory and anti-anaphylactic activities [12,17,18] The P.kurroa has been recently reported to inhibit arthritis through inhibition of pro-inflammatory cytokines and angiogenesis and which have protective effects against 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats and non alcoholic fatty liver disease [19,20,21]. The active component Picroliv against Leishmaniadonovani infections in Mesocricetusauratus and hepatoprotective compound in mice [22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice

Krupashree¹,

Rachitha²,

Jayashree³

et al. 2018

IJCRR

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Objectives: The aim of the present study is to evaluate hepatoprotective effect of Picrorhizakurroaextracts (PKE) against Fumonisin b1 (Fb1) induced hepatotoxicity. Methods: Hepatoprotective analysis was done by estimating serum biochemical parameters Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), antioxidant enzyme status lipid peroxidations, ROS generation, and protein carbonyls were also estimated to know the oxidative damage. Further protein expressions were confirmed by western blotting. Results: The mice treated with 100 and 200 mg/kg b.wt PKE, showed a significant reduction in serum AST and ALT to 175.41 ± 7.82, 68.52±1.57 and 126.64 ± 1.72, 57.41±1.28 units/ml of serum respectively. The decrease in antioxidant levels with Fb1 was significantly restored with 100 and 200 mg/kg by wt PKE. The lipid peroxidation products with Fb1 treatment was also reduced with PKE supplementation. The Fb1 induced ROS was reduced with 60 and 140% by 100 and 200 mg/kg/ by wt PKE administration. The PKE restored CAT and GPx enzyme/protein levels and further down regulated caspase 8 and caspase 3 expression. Conclusion: The present observations suggested that the treatment with PKE extract enhance the recovery from Fb1 induced hepatic damage due to its antioxidant and hepatoprotective property.

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“…NADPH oxidase enhanced the secretions of cytokines NF-κβ that interacts with iNOS to form a peroxynitrite, a toxic substance for neurons (Krupashree, Kumar, Rachitha, Jayashree, & Khanum, 2014).…”

Section: Convolvulus Pluricaulis Choisymentioning

confidence: 99%

Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders

Wahid

Ali

Saqib

et al. 2020

Phytotherapy Research

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Alzheimer's disease (AD) is clinically characterized as memory deficits, altered behavior and impaired cognitive functions. The most important risk factor for AD is aging and mounting. Evidences suggested in different studies that traditionally used plants in Asia, China, and Europe significantly affect aging and AD involved neurodegeneration pathways. Research into ethnobotanicals for impaired memory and cognition has been burgeoned in last decades. The inclusion and exclusion criteria for the plant selection were based on reputed herbs recommended for treatment of neurological disorders and their scientific validation to cure neurodegenerative disorders. A range of traditional plants imparts effects via acetylcholinesterase activity, β-amyloid peptide formation in plaques, neurotrophic factors and through antioxidant activity. On one side preclinical investigations identified promising drug candidates for AD, on the other side, clinical evidences are still pending. Presently, according to WHO, around more than 80% world population relay on natural remedies to cure their health related issues. Plants contain rich source of primary and secondary metabolites for improving health problems. Pharmaceutical industry is facing intriguing challenges like elevated cost and unendurable risk management due to the high burden of neurodegenerative disorders. A significant shift of drug discovery is being witnessed from synthetic moieties to herbal formulation.

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Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth

Cited by 37 publications

References 31 publications

Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis

Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis

Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice

Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders

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