Chemical composition, aroma evaluation, and inhibitory activity towards acetylcholinesterase of essential oils from Gynura bicolor DC.

Miyazawa, Mitsuo; Nakahashi, Hiroshi; Usami, Atsushi; Matsuda, Naoki

doi:10.1007/s11418-015-0961-1

Cited by 28 publications

(16 citation statements)

References 11 publications

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“…The leaf and stem oil inhibited AChE (53 %) at a concentration of 0.50 µg/mL with ID 50 values of 85 and 92 µg/mL, respectively. Both oils showed better results than pulegone [84]. EO obtained from fresh Chaerophyllum aromaticum L. root and aerial parts exhibited significant anticholinesterase and antioxidant activities [85].…”

Section: In Vitro Studiesmentioning

confidence: 99%

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Benny

Thomas

2018

Planta Med

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Alzheimerʼs disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiology. Currently, few drugs are available for the management of Alzheimerʼs disease and the treatment provides only symptomatic relief. Our aim is to review the relevant in vitro, in vivo, and clinical studies focused toward the potential uses of essential oils in the treatment of Alzheimerʼs disease. Scientific databases such as PubMed, ScienceDirect, Scopus, and Google Scholar from April 1998 to June 2018 were explored to collect data. We have conducted wide search on various essential oils used in different models of Alzheimerʼs disease. Out of 55 essential oils identified for Alzheimerʼs intervention, 28 have been included in the present review. A short description of in vivo studies of 13 essential oils together with clinical trial data of Salvia officinalis, Salvia lavandulifolia, Melissa officinalis, Lavandula angustifolia, and Rosmarinus officinalis have been highlighted. In vitro studies of remaining essential oils that possess antioxidant and anticholinesterase potential are also mentioned. Our literary survey revealed encouraging results regarding the various essential oils being studied in preclinical and clinical studies of Alzheimerʼs disease with significant effects in modulating the pathology through anti-amyloid, antioxidants, anticholinesterase, and memory-enhancement activity.

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Section: In Vitro Studiesmentioning

confidence: 99%

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Benny

Thomas

2018

Planta Med

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“…Furthermore, we found that this aqueous extract at 2% and 4% displayed markedly antioxidative protection for human umbilical vein endothelial cells against high glucose induced damage. It is reported that the essential oil prepared from G. bicolor could inhibit acetylcholinesterase activity (Miyazawa and others ). The study of Teoh and others () revealed that chemical constituents of G. bicolor exhibited cytotoxic effects against colon carcinoma cells.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Gynura Bicolor Attenuated Hepatic Steatosis, Glycative, Oxidative, and Inflammatory Injury Induced by Chronic Ethanol Consumption in Mice

Yin

Wang

Liu

et al. 2017

Journal of Food Science

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Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses. Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin, adiponectin, leptin, and ghrelin. GAE at both doses decreased lipid accumulation, and at high dose improved hormones abnormality. Histological data revealed that GAE supplement mitigated hepatic lipid deposit. Ethanol increased plasma N -(carboxyethymethyl)-lysine and pentosidine levels. GAE at high doses lowered those glycative factors. Ethanol depleted glutathione content, increased CYP2E1 activity and reactive oxygen species production, and reduced the activity of glutathione peroxide, glutathione reductase and catalase in liver. GAE supplement at both doses reversed these alterations and attenuated hepatic oxidative stress. GAE supplement also at both doses decreased hepatic inflammatory cytokines release in ethanol treated mice. These findings support that leaves of G. bicolor is a functional food with liver protective activities against ethanol.

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“…Some monoterpenes, among them eugenol and menthol, inhibit the activity of acetylcholinesterase, which is the site of action of azamethiphos. But inhibition only occur when very high concentrations of the monoterpenes are applied; thus, it cannot be considered their primary site of action [33][34][35][36]. Nevertheless, an interaction involving this enzyme, which subsequently modifies its interaction with azamethiphos, cannot be overruled.…”

Section: Discussionmentioning

confidence: 99%

Botanical monoterpenes synergise the toxicity of azamethiphos in the vector of Chagas disease, Triatoma infestans (Hemiptera: Reduviidae)

Reynoso

Seccacini

Zerba

et al. 2020

Tropical Med Int Health

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objective To investigate what toxicological interactions occur when binary combinations of azamethiphos and botanical monoterpenes (eugenol, menthol or menthyl acetate) are applied to Triatoma infestans. methods The toxicity of binary mixtures of azamethiphos and sublethal doses of a monoterpene (eugenol, menthol or menthyl acetate) was evaluated in nymphs of the first stage of T. infestans. Experiments using exposure to filter papers and topical application were carried out. Values of Lethal Concentration 50% (LC50) were calculated in the first case, and values of Lethal Dose 50% (LD50) in the second. results The LC50 of azamethiphos applied on filter paper was 50.3 µg/cm 2. However, when it was simultaneously applied with a sublethal concentration of monoterpene, its toxicity increased (LC50 with eugenol = 11.20 µg/cm 2 , LC50 with menthyl acetate = 5.30 µg/cm 2 , LC50 with menthol = 7.26 µg/cm 2). When applied topically, the LD50 of azamethiphos was 7.85 µg/insect, but its toxicity drastically increased when it was applied together with sublethal doses of menthol (LD50 = 0.00016 µg/insect) or menthyl acetate (LD50 = 0.00051 µg/insect). The simultaneous application with eugenol did not significantly change azamethiphos toxicity (LD50 = 12.79 µg/ insect). conclusions The toxicity of azamethiphos in T. infestans was synergised when it was applied together with eugenol, menthol or menthyl acetate on a filter paper. However, only menthol and menthyl acetate synergysed azamethiphos when mixtures were topically applied. The drastic effects of menthol and menthyl acetate in topical application experiments should be further studied as they could be the basis for developing more efficient triatomicidal products with a lower content of conventional insecticides than those currently used for controlling T. infestans. keywords kissing bug, Chagas disease, synergism, monoterpene, insecticide Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 15 (life on land), SDG 17 (partnerships for the goals)

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Chemical composition, aroma evaluation, and inhibitory activity towards acetylcholinesterase of essential oils from Gynura bicolor DC.

Cited by 28 publications

References 11 publications

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Aqueous Extract of Gynura Bicolor Attenuated Hepatic Steatosis, Glycative, Oxidative, and Inflammatory Injury Induced by Chronic Ethanol Consumption in Mice

Botanical monoterpenes synergise the toxicity of azamethiphos in the vector of Chagas disease, Triatoma infestans (Hemiptera: Reduviidae)

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