Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

Abstract

Among the species belonging to the Aspergillus section Versicolores, Aspergillus creber has been poorly studied and still unexplored for its biological activities. The present study was undertaken to analyze A. creber extract and to evaluate its in vitro antimicrobial and antioxidant activities. UHPLC-MS/MS analysis of A. creber extract allowed the characterization of five known fungal metabolites including: asperlactone, emodin, sterigmatocystin, deoxybrevianamide E, and norsolorinic acid. The highest antimicrobial activity was displayed against Candida albicans, with a mean strongest inhibition zone of 20.6 ± 0.8 mm, followed by Gram-positive drug-resistant bacteria. The MIC values of A. creber extract varied from 0.325 mg/ml to 5 mg/ml. A. creber extract was shown a potent antioxidant activity and a high level of phenolic compounds by recording 89.28% scavenging effect for DPPH free radical, 92.93% in ABTS assay, and 85.76 mg gallic acid equivalents/g extract in Folin-Ciocalteu assay. To our knowledge, this is the first study concerning biological and chemical activities of A.creber species. Based on the obtained results, A.creber could be a promising source of natural antimicrobial and antioxidant compounds.

Antimicrobial and cytotoxic activity of fungal mycelial extracts from aquatic environments in the Amazon

“…The strain demonstrated fungistatic and fungicidal activity against C. albicans. The results obtained are similar to those found by Sakhri et al (2019), in which an Aspergillus crebe strain exhibited only antifungal activity when evaluated against the pathogens: E. coli, P. aeruginosa, C. albicans, and C. glabrata. Aspergillus genus has a worldwide distribution and contain a large number of species, which stands out for producing a range of natural products with biological activities (Lotfy et al, 2018), such as asperlicin, echinocandin B, and fumagillin isolated from A. alliaceus, A. nidulans, and A.…”

Aflatoxin biosynthetic pathway extrolites in airborneAspergilli seriesVersicolores

“…We showed the biosynthesis of norsolorinic acid by A. jensenii, A. protuberus, A. puulaauensis and A. tabacinus when it was previously only reported for A. creber (Sakhri et al, 2019). This study also provides a first insight into the biosynthesis of STE precursors (versicolorin A and 6-demethylsterigmatocystin) and derivatives (8-O-methylsterigmatocystin and 5-methoxysterigmatocystin) by Aspergillus species of the series Versicolores.…”

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

“…[84]. All these fungi are able to produce many metabolites [85][86][87][88][89]. Water, ethanol and methanol extracts of S. officinalis, S. cryptantha Montbret and Aucher and S. tomentosa Mill.…”