Yams (Dioscorea species) and cocoyam (ariods) are major staples that are widely consumed in tropical and subtropical countries, especially Nigeria.Up till now, there is limited information on the phenolic compounds and antioxidant activity of yams and cocoyam species in this tropical region.Three under-utilized Nigerian yams (Dioscoreacayenensis, Dioscoreadumetorum, Dioscoreabulbifera) and cocoyam (Xanthosomamaffa (Scoth)) were analyzed for total polyphenols, total flavonoids and antioxidant activities applying three commonly used assays: DPPH, ABTS, and ORAC. Correlation analysis wasperformed to determine the contribution of polyphenols and flavonoids toantioxidant activities. The total polyphenol content of the samples ranged from 7.02 to 163.37mg Gallic Acid Equivalent(GAE/100gFW), while the total flavonoid content of the samples ranged from 3.14 to 155.38mg Catechin Equivalent(CE/100gFW). The antioxidant activities evaluated by DPPHassay ranged from 88.17 to 729.39 Trolox Equivalent (TE/100gFW), whileABTSvalues ranged from 32.49 to 756.0 Trolox Equivalent (TE/100gFW)and ORAC assay ranged from 459.29 to 669.45mg Trolox Equivalent (TE/100gFW) respectively. Significant correlation was observed between total polyphenols and DPPH radical scavenging activity (R 2 =0.897);total polyphenols and ABTS(R 2 =0.931),andbetween total polyphenols and ORAC (R 2 =0.707). The correlation between total flavonoid and DPPH(R 2 =0.992), and between total flavonoidand ABTS(R 2 =0.744) respectively. The polyphenol, flavonoid and antioxidant activity of Xanthosomamaffa (Scoth) were higher and significantly different (P<0.05) from the yamsDioscoreaspecies. Extracts from these under-utilized yams and cocoyam tubers can play a considerable role in boosting immunity against human diseases caused by free radical reactions like cancer, cardiovascular disease, diabetes and aging.