Chemical compositions of raspberry leaves influenced by growth season, cultivars and leaf position

Wu, Liyang; Yang, Jing; Wang, Qianqian; Li, Nana; Liu, Yongping; Duan, Anbang; Wang, Tao

doi:10.1016/j.scienta.2022.111349

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…This stoichiometry may be an effective predictor of the nutritional requirement and nutrition level in Z. armatum. Earlier reports have shown that leaf positions clearly affected the N, P, AA, SP, SS, TP and TF content in peach, raspberry and Manihot esculenta Crantz leaves [13,16,18]. For example, in cassava, arginine content in apical leaves reached 2.03 g 100 g −1 , while that of middle and basal leaves were 1.91 g 100 g −1 and 1.34 g 100 g −1 , respectively [16].…”

Section: Discussionmentioning

confidence: 91%

“…The nutrient contents of the middle position leaves were higher than those of the top and bottom leaves [16]. In the study of raspberry, the apical leaves accumulated higher contents of total phenolic (TP), total flavonoids (TF) and quercetin-3-glucuronide, kaempferol-3-rutinoside, ellagic acid, but the basal leaves contained higher condensed tannins and saponins [13]. These studies also showed that the variations in chemical compounds and their contents in Agave potatorum, cassava and raspberry are influenced by the interaction between plant ages and leaf position or growth season [13,16,17].…”

Section: Introductionmentioning

confidence: 97%

“…The controllable factors include plant ages, leaf position, developmental stages, harvest stages, cultivars, etc. [13], and the uncontrollable factors include pests, diseases, climate and environment, etc. [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition and Antioxidant Activity of Zanthoxylum armatum Leaves in Response to Plant Age, Shoot Type and Leaf Position

Qian

et al. 2023

Forests

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Zanthoxylum armatum (Z. armatum) leaves represent more than 50% of by-products with promising potential applications, and there are still largely unknown variations in chemical composition and antioxidant activity in its leaves. In the present study, the changes in carbon (C), nitrogen (N) and phosphorous (P), soluble protein (SP), amino acid (AA), soluble sugar (SS), total phenol (TP) and total flavonoids (TF) content as well as antioxidant capacity in Z. armatum leaves from two plant ages between two shoot types and three leaf positions were investigated. Our results showed that there are significant effects of plant age, shoot type and leaf position and their interactions on almost all the tested parameters. Shoot types were the main factor affecting the accumulation of chemical compositions and antioxidant capacity, followed by leaf positions and plant ages. Shoot type and leaf position had stronger effects than plant age. Statistical analysis revealed a series of correlations between antioxidant capacity, TP and chemical elements. Z. armatum leaves, an agricultural by-product, showed significant differences in chemical composition and antioxidant activity in response to plant age, shoot type and leaf position, which can be valuable to incentive its cultivation management strategy and its better utilization for economic and environmental benefits.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 97%

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Chemical Composition and Antioxidant Activity of Zanthoxylum armatum Leaves in Response to Plant Age, Shoot Type and Leaf Position

Qian

et al. 2023

Forests

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“…Among them, the apical and middle leaves contained more polyphenols, while the old leaves contained more saponins. Their hydrolyzable tannin contents were 1.4-1.6 times those of free phenols, with a maximum of about 300 mg/g, with quercetin-3-glucuronide (Q3GR) being the highest, at about 5-10 mg/g DW [14].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Extraction–Purification Process for Raspberry Leaf Polyphenols and Their In Vitro Activities

Yang,

Wu,

Wang

et al. 2023

Molecules

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To improve the utilization value of raspberry leaves, the extraction and purification conditions of phenolic compounds from raspberry leaves were optimized, and the contents of phenolic compounds and the biological activities of extracts were studied. After steam explosion pretreatment at 115 °C for 15 min, raspberry leaf extract with a total phenolic content (TPC) of 136.30~140.51 mg GAE/g was obtained via homogenization and ultrasound-assisted extraction. In addition, the adsorption relationship between raspberry leaf polyphenols and middle polar XDA-6 macroporous resin was best described by the Langmuir model, and tended to be monolayer adsorption. Its adsorption kinetics best resembled the pseudo second-order kinetic model, and it was speculated that this was influenced by multiple factors. According to the optimal integrated extraction–purification process, the TPC of the extracts increased to 738.98 mg GAE/g after one application of purification and 905.27 mg GAE/g after two applications of purification. Moreover, the latter case showed the highest antioxidant activity and α-glucosidase inhibition activity, and the content of the most typical compound, quercetin-3-glucuronide, reached 199.69 mg/g. SE has a double-edged effect, and is more conducive to the release of active substances as a pre-treatment method. This study provides a theoretical basis for the efficient use of raspberry leaves, further improving their medicinal and economic value.

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“…In Europe and the United States, raspberry is known as the “Fruit of Life.” According to the data from the Food and Agriculture Organization of the United Nations (FAO), it is the third largest high-value small berry in the world, with an annual demand of more than 2 million tons ( 13 ). Raspberry leaves are also rich in polyphenols, ellagic acid, quercetin and their derivates ( 14 ). They were included in Chinese Mmedicine and Food Homologous List in 2002 ( 15 ), the Chinese Cosmetic Raw Materials list in 2015 ( 16 ), the Scientific Committee of the British Herbal Medicine Association in 1983 ( 17 ), and the European Community Herbal Medicine Monograph published by the European Medicines Agency (EMA) in 2012 ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated 16s RNA sequencing and network pharmacology to explore the effects of polyphenol-rich raspberry leaf extract on weight control

Wang,

Yang,

Huang

et al. 2024

Front. Nutr.

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IntroductionObesity is recognized as a chronic low-grade inflammation associated with intestinal flora imbalance, leading to dyslipidemia and inflammation. Modern research has found that polyphenols have anti-obesity effects. However, the mechanism of action of raspberry leaf extract (RLE) with high polyphenols in regulating obesity is still unknown. This study investigated the improvement effect of supplementing RLE on high-fat diet (HFD) induced obesity in mice.MethodsRLE was used to intervene in HFD induced C57BL/6J male mice during prevention stage (1-16 weeks) and treatment stage (17-20 weeks). Their weight changes and obesity-related biochemical indicators were measured. The changes in intestinal flora were analyzed using 16S rRNA sequencing, and finally the targets and pathways of the 7 typical polyphenols (quercetin-3-O-glucuronide, ellagic acid, kaempferol-3-O-rutinoside, chlorogenic acid, brevifolin carboxylic acid, quercetin-3-O-rutinoside, and quercetin) of RLE in the regulation of obesity were predicted by network pharmacology approach.Results and discussionThe results showed that RLE effectively prevented and treated weight gain in obese mice induced by HFD, alleviated adipocyte hypertrophy, reduced Interleukin-6 and Tumor Necrosis Factor Alpha levels, and improved intestinal flora, especially Muriaculaceae, Alistipes and Alloprevotella, and decreased the Firmicutes/Bacteroidota ratio. Network pharmacology analysis selected 60 common targets for 7 RLE polyphenols and obesity. Combined with protein-protein interaction network, enrichment analysis and experimental results, TNF, IL-6, AKT1, and PPAR were predicted as potential key targets for RLE polyphenols.ConclusionThe potential mechanism by which polyphenol-rich RLE regulates obesity may be attributed to the specific polyphenols of RLE and their synergistic effects, therefore RLE has a great anti-obesity potential and may be used as a means to alleviate obesity and related diseases.

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Chemical compositions of raspberry leaves influenced by growth season, cultivars and leaf position

Cited by 10 publications

References 27 publications

Chemical Composition and Antioxidant Activity of Zanthoxylum armatum Leaves in Response to Plant Age, Shoot Type and Leaf Position

Chemical Composition and Antioxidant Activity of Zanthoxylum armatum Leaves in Response to Plant Age, Shoot Type and Leaf Position

An Integrated Extraction–Purification Process for Raspberry Leaf Polyphenols and Their In Vitro Activities

Integrated 16s RNA sequencing and network pharmacology to explore the effects of polyphenol-rich raspberry leaf extract on weight control

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