Chemical constituents and antioxidative, anti-inflammatory and anti-proliferative activities of wild and cultivated Corydalis saxicola

GuangHui, Xie; Jin, Shuyi; Li, Hongting; Ai, Mingkun; Feng, Han; Dai, Yiqun; Tao, Wei; Yu, Zhu; Zhao, Yucheng; Qin, Min-Jian

doi:10.1016/j.indcrop.2021.113647

Cited by 17 publications

(11 citation statements)

References 65 publications

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“…Studies have shown that it is rich in alkaloids, steroids, triterpenes, flavonoids, nucleosides, and other compounds, although alkaloids are the main group of compounds (Wu et al 2007;Guo et al 2021;Xie et al 2021). Most of these have considerable biological activities, such as antiviral, anti-inflammatory, anti-tumor, hepatoprotective, bacteriostatic, inhibition of acetylcholinesterase, analgesia, and other activities, especially for the treatment of hepatitis B, liver cancer, and cirrhosis, as well as other diseases (Kuai et al 2020;Ju et al 2021;Zhang et al 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Even though C. saxicola has high medicinal value and thus considerable economic benefits, resource output is sparse. This limitation is compounded by harsh natural growth habitats, low reproductive output, and difficulties in establishing large stands or populations (Xie et al 2021). Consequently, large pools of natural stands and reserves of C. saxicola are very limited.…”

Section: Introductionmentioning

confidence: 99%

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Shoot organogenesis and plant regeneration from leaf and petiole explants of Corydalis saxicola Bunting

Pang

Xiong

Zeng

et al. 2022

In Vitro Cell.Dev.Biol.-Plant

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Corydalissaxicola Bunting, a medicinal herb known for alkaloids, grows mainly in Guizhou province and northwest Guangxi province of China. In this study, for the first time for this plant, an efficient adventitious shoot proliferation and regeneration system via shoot organogenesis from leaf and petiole explants was established. Cytokinins, including 6-benzyladenine (BA) and thidiazuron (TDZ), induced callus and then shoot organogenesis. Most adventitious shoots were induced from leaf explants on Murashige and Skoog (MS) medium (pH 6.5) supplemented with 2.0 µM BA and 0.5 µM α-naphthaleneacetic acid (NAA). This medium was also optimal for shoot proliferation. The rooting ½MS medium was supplemented with 1.0 µM indole-3-butyric acid (IBA) and 0.2 µM NAA; 95.7% of shoots induced roots within 30 d and 91% of plantlets survived on a peat:vermiculite (1:1, v:v) substrate after 90 d.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shoot organogenesis and plant regeneration from leaf and petiole explants of Corydalis saxicola Bunting

Pang

Xiong

Zeng

et al. 2022

In Vitro Cell.Dev.Biol.-Plant

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“…Several studies have given recommendations for the cultivation of this plant. However, in a recent study, wild and cultivated CSBs varied in composition ( Xie et al, 2021 ).…”

Section: Botanical Descriptionmentioning

confidence: 99%

“…It was firstly documented to have properties of clearing away heat and detoxication, removing dampness, relieving pain and hemostasis in a book named Guizhou Herbal Medicine. Nowadays, pharmacological studies have provided evidence that this ethnomedicine can treat liver diseases and also show that it also has important pharmacological activities such as anticancer, anti-inflammation ( Liang et al, 2016 ; Xie et al, 2021 ). Meanwhile, CSBTA are the main active constituents to exert the pharmacological effects described as before.…”

Section: Introductionmentioning

confidence: 99%

The Traditional Uses, Phytochemistry, Pharmacokinetics, Pharmacology, Toxicity, and Applications of Corydalis saxicola Bunting: A Review

Guo

Zhao²,

Chang

et al. 2022

Front. Pharmacol.

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Background:Corydalis saxicola Bunting (CSB) is a perennial herb belonging to genus Corydalis (Papaveraceae), called “Yan-huang-lian” in the Chinese folk. Traditionally, it is used to treat acute conjunctivitis, corneal pannus, acute abdominal pain, hemorrhoidal bleeding, haematochezia, swelling, hepatitis, cirrhosis and liver cancer based on traditional Chinese medicine (TCM) concepts.Purpose: This review aims to summarize and analyze the pharmacokinetics, pharmacological and toxicological properties of CSB and its extracts; to highlight the relevance of modern pharmacology to traditional pharmacology; also to assess its therapeutic potential.Methods: CSB related literatures were searched and screened from databases including PubMed, Web of Science and CNKI. The selected literatures provided reliable source identification evidences.Results: In traditional medicine concepts, CSB has the effects of clearing away heat and detoxification, eliminating dampness, relieving pain, and stopping bleeding. Its modern pharmacology includes hepatoprotective, anticancer, anti-inflammatory, analgesic, antibacterial, anti-oxidative effects. Further, some pharmacological effects support its traditional uses. The CSB total alkaloids (CSBTA) are the main constituents isolated from this plant, and they exert the major of the pharmacological effects. Toxicological studies have shown that the toxicity of CSBTA is mild and reversible in rodents and beagle dogs.Conclusion: Although the present study summarizes the botany, phytochemistry, pharmacokinetics, pharmacology, toxicity, and applications of this plant, it is still necessary to systemically evaluate the chemistry, safety and parameters related to drug metabolism of the extracts or compounds from this plant before or in clinical trials in the future. Meanwhile, cancers and inflammatory-related diseases may be new research directions of this ethnomedicine.

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“…In tradition, the whole plant of CSB, namely Yan-huang-lian is used to cure diseases in Chinese folk. On the basis of traditional Chinese medicine theories, its use spectrum contains acute conjunctivitis, corneal pannus, acute abdominal pain, hemorrhoidal bleeding, haematochezia, swelling, hepatitis, cirrhosis, and liver cancer [ 3 , 4 , 5 ]. Until now, pharmacological studies have provided evidence that this ethnomedicine can treat liver diseases and show that it also has significant pharmacological properties such as anticancer, anti-inflammatory, antibacterial, anti-oxidative, analgesic, and hepatoprotective effects [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications

Feng

Chen

Wang

et al. 2023

IJMS

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Corydalis saxicola Bunting (CSB), whose common name in Chinese is Yanhuanglian, is a herb in the family Papaveraceae. When applied in traditional Chinese medicine, it is used to treat various diseases including hepatitis, abdominal pain, and bleeding haemorrhoids. In addition, Corydalis saxicola Bunting injection (CSBI) is widely used against acute and chronic hepatitis. This review aims to provide up-to-date information on the botanical distribution, description, traditional uses, phytochemistry, pharmacology, and clinical applications of CSB. A comprehensive review was implemented on studies about CSB from several scientific databases, such as SciFinder, Elsevier, Springer, ACS Publications, Baidu Scholar, CNKI, and Wanfang Data. Phytochemical studies showed that 81 chemical constituents have been isolated and identified from CSB, most of which are alkaloids. This situation indicates that these alkaloids would be the main bioactive substances and that they have antitumour, liver protective, antiviral, and antibacterial pharmacological activities. CSBI can not only treat hepatitis and liver cancer but can also be used in combination with other drugs. However, the relationships between the traditional uses and modern pharmacological actions, the action mechanisms, quality standards, and the material basis need to be implemented in the future. Moreover, the pharmacokinetics of CSBI in vivo and the toxicology should be further investigated.

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Chemical constituents and antioxidative, anti-inflammatory and anti-proliferative activities of wild and cultivated Corydalis saxicola

Cited by 17 publications

References 65 publications

Shoot organogenesis and plant regeneration from leaf and petiole explants of Corydalis saxicola Bunting

Shoot organogenesis and plant regeneration from leaf and petiole explants of Corydalis saxicola Bunting

The Traditional Uses, Phytochemistry, Pharmacokinetics, Pharmacology, Toxicity, and Applications of Corydalis saxicola Bunting: A Review

Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications

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