Chemical constituents and biological activities ofViburnum macrocephalumf.keteleeri

Abstract

Three new compounds (1-3) and seven known compounds (4-10) have been isolated from the ethanolic extract of Viburnum macrocephalum f. keteleeri using bioactivity-guided fractionation and identified as methyl (2-α-L-rhamnopyranosyloxy)acetate (1), methyl (2R-3-α-L-rhamnopyranosyloxy)glycerate (2), methyl (3R-4-α-L-rhamnopyranosyloxy-3-hydroxy)butanoate (3), bridelionoside B (4), (6S,7E,9R)-roseoside (5), linarionoside A (6), 3,7,11-trimethyl-1,6-dodecadien-3,10,11-triol (7), (+)-8-hydroxylinalool (8), β-sitosterol (9) and daucosterol (10). The structures of 1-3, including absolute configurations, were determined by spectroscopic data (H and C NMR, HSQC, HMBC and ORD) and chemical methods. In addition, compounds 1-8 were assayed for their insecticidal and antimicrobial activities. Compounds 7 and 8 exhibited moderately insecticidal effects against Mythimna separata with LD values of 180 and 230 μg g, respectively. Compounds 2, 3, 7 and 8 showed varying antimicrobial activities with IC values ranging from 125 to 529 μM.

Recent Advance on Chemistry and Bioactivities of Secondary Metabolites from Viburnum Plants: An Update

“…Twenty sesquiterpenoids ( 125 – 144 ) were found from the genus Viburnum , and a great proportion of them were megastigmanes ( Table 4, Figure 4). The bioactivity‐guided fractionation of Viburnum macrocephalum f. keteleeri led to the isolation of an antimicrobial and insecticidal hydroxy nerolidol, identified as 3,7,11‐trimethyl‐1,6‐dodecadien‐3,10,11‐triol ( 125 ) along with three megastigmane glucosides 137 , 141 and 142 [38] . Cyperenol acid ( 126 ) and spathulenol ( 127 ), possessing significant neuroprotective activities against H 2 O 2 ‐induced damage in SH‐SY5Y cells, as well as isololiolide ( 133 ) were isolated and identified from the leaves of V. odoratissmum [10] .…”

“…were also secoiridoid glucosides. Other than the iridoid constituents above, monoterpenoids 185–188 existed in four different species including V. macrocephalum f. keteleeri , [38] V. plicatum Thunb. var.…”

“…Five steroids ( 406 – 410 ) were found from V. odoratissmum and V. cylindricum ( Table 12, Figure 12). [8,9,42] And compounds 411 – 413 were isolated from the branches of V. maceocephalum f. keteleeri [38] …”

Phytochemical profiling, and anti-oxidant, anti-bacterial, and anti-inflammatory properties of Viburnum coriaceum Blume

“…V. opulus is used in homeopathic medicine for the treatment of dysmenorrhea and have other health benefits too [5,6]. Viburnum lantana [7], Viburnum macrocephalum [8], Viburnum grandiflorum [9], Viburnum dilatatum [10], etc. are some other important species with reported medicinal properties.…”

“…are some other important species with reported medicinal properties. Antioxidant [7,10], anti-microbial [8,9,11], anti-diabetic [10], anti-inflammatory [12,13], anti-nociceptive [12], and hepato-protective [14] effects were also reported from these species. A number of bioactive compounds have been isolated from different Viburnums including monoterpenes, iridoids and iridoid glycosides [15,16].…”