Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb

Dar, Shabir Ahmad; Bhushan, Anil; Gupta, Prasoon

doi:10.1007/978-981-15-5917-4_12

Cited by 7 publications

(7 citation statements)

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“…[21] Additionally, in a separate study, a methanol extract of the leaves exhibited potent antioxidant activity against DPPH, with an IC 50 value of 35 μg/mL for radical scavenging. [22] The activity of extract was lower than the activity of the positive controls Quercetin and BHT. The difference in the DPPH scavenging activity and reducing power from one extract to another may be due to the difference in chemical composition and content of phenolic compounds.…”

Section: Phytochemical Studymentioning

confidence: 90%

“…These findings align with previous studies showing analgesic effects in both formalin-induced phases. [11,22] This activity may be partly due to marrubiin's inhibitory action on formalin-induced pain. [33] Additionally, Kanyonga et al [34] demonstrated that a methanol extract of M. vulgare exhibited analgesic activity comparable to acetylsalicylic acid.…”

Section: Formalin Testmentioning

confidence: 99%

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Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Aitbaba,

Kabdy,

Baslam

et al. 2024

Chemistry & Biodiversity

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Marrubium vulgare L. has a long history of use in traditional herbal medicine for the treatment of respiratory tract infections, inflammatory conditions, and pain. This study aimed to investigate the chemical composition, acute toxicity, and antinociceptive effects of the aqueous extract from M. vulgare leaves (AEMV). Antioxidant activity was evaluated using DPPH and reducing power assays. The chemical composition of AEMV was determined through LC‐MS/MS, and the levels of total phenolics, flavonoids, and condensed tannins were quantified. Acute oral toxicity was assessed in male Swiss mice with a single oral dose of AEMV (1, 2, 5 g/kg). The analgesic impact was examined through writhing, hot plate, and formalin tests. Our findings not only confirmed the safety of the extract in animal models but also revealed significant antioxidant activity in AEMV. High‐performance liquid chromatography (HPLC) analysis identified important bioactive compounds, with marrubiin being a major component. Furthermore, AEMV demonstrated robust antinociceptive properties in all conducted tests, highlighting its potential as a valuable natural source of bioactive compounds suitable for a wide range of therapeutic applications.

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Section: Phytochemical Studymentioning

confidence: 90%

Section: Formalin Testmentioning

confidence: 99%

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Aitbaba,

Kabdy,

Baslam

et al. 2024

Chemistry & Biodiversity

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“…It is also consumed as a remedy for respiratory tract diseases. 1 The therapeutic properties of M. vulgare which include anti-inflammatory, hypoglycemic, analgesic, antispasmodic, vasorelaxant, anticoagulant, and antidiabetic effects are partly attributed to marrubiin ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO₂extraction ofMarrubium vulgare: intensification of marrubiin

et al. 2021

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“…However, the search to identify such natural compounds is going on with great peace throughout the world. Marrubium vulgare which contains a good class of secondary metabolites like phenols, flavonoids, diterpenoids 8 is also evaluated for various biological activities including diabetes. 9 However previous studies of the herb related to its antidiabetic activity was restricted to crude extracts only [10][11][12] which contains almost all classes of compounds (phenols, flavonoids, diterpenoids tannins, essential oils, sugars), so to identify the active agent remains always a mystery.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Quantification of Antidiabetic and Antioxidant Components from Saturated Fraction of Marrubium vulgare. L Leaves

Ahmad

Parveen²,

Prasoon

et al. 2021

Int J Life Sci Pharm Res

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Marrubium vulgare L. (Lamiaceae), aerial parts has been traditionally used to cure a variety of diseases including diabetes. A good class of secondary metabolites is present in the herb; however, the potential antidiabetic agent consistently stays a secret.. The present study aimed to identify the antidiabetic agents present in M. vulgare leaf extract. The isolation of compounds from the saturated fraction was done by column chromatography and their structures were elucidated using NMR, HRMS and MS spectroscopic methods. . The antidiabetic profiling of Methonoloc Extract (MeOH) extract (500 mg/kg b.w) and its chloroform fraction (250 mg/kg b.w) was investigated in STZ- induced diabetic rats. Four bioactive compounds namely marrubiin (MV-17), marrubinone B (MV-27), ladanein (MV-19) and apigenin 7-O-β-D-(6''- p- coumaroyl) glucoside (MV-25), were isolated from chloroform fraction, oleic acid(MV-20) and Palmitic acid (MV-21) from hexane fraction of M. vulgare leaf. Among these known compounds we first time report oleic and palmitic acid in M. vulgare. Both MeOH extract (500 mg/kg b.w) and its CHCl3 fraction (250 mg/kg b.w) significantly (p˂0.001) lowered the blood glucose level. Quantitative estimation by HPLC showed the highest concentration of MV-17, MV-20 and MV-27 in the CHCl3 fraction. Moreover this fraction also showed significant antioxidant potential measured by DPPH assay. These results confirmed that the hypoglycemic potential of chloroform fraction (IIIM-2) may be largely due to compounds MV-17, 27 and 20.

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Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb

Cited by 7 publications

References 50 publications

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Supercritical CO₂extraction ofMarrubium vulgare: intensification of marrubiin

Isolation and Quantification of Antidiabetic and Antioxidant Components from Saturated Fraction of Marrubium vulgare. L Leaves

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Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb

Cited by 7 publications

References 50 publications

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract

Supercritical CO2extraction ofMarrubium vulgare: intensification of marrubiin

Isolation and Quantification of Antidiabetic and Antioxidant Components from Saturated Fraction of Marrubium vulgare. L Leaves

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Product

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Supercritical CO₂extraction ofMarrubium vulgare: intensification of marrubiin