Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Abstract

Dendrobium officinale, a plant in the Orchidaceae family, has been used in traditional Chinese medicine for thousands of years. Sweet and slightly cold in nature, it can invigorate the stomach, promote fluid production, nourish Yin, and dissipate heat. Over the past decade, more than 60 compounds have been derived from D. officinale, including flavonoids, bibenzyl, and phenanthrene. Various studies have explored the underlying pharmacological mechanisms of these compounds, which have shown antitumor, hypoglycemic, hypertensive, gastrointestinal-regulatory, visceral organ protection, antiaging, and neurorestorative effects. This paper presents a systematic review of the structural classification, biological activity, and pharmacological mechanisms of different chemical components obtained from D. officinale over the past decade. This review aims to provide a reference for future study and establish a foundation for clinical applications. Furthermore, this review identifies potential shortcomings in current research as well as potential directions and methodologies in future plant research.

Traditional Chinese medicine treats ulcerative colitis by regulating gut microbiota, signaling pathway and cytokine: Future novel method option for pharmacotherapy

“…Dendrobium nobile Lindl. has the anti-inflammatory, antibacterial and immunomodulatory effects in the field of modern medical research, suggesting that it could be considered as a therapeutic agent for UC [ 81 ]. Dendrobium officinale leaf phenolics could act in multiple ways to ameliorate DSS-induced colitis, mainly by decreasing the relative abundance of parasutterella_excrementihominis, ligilactobacillus_murinus, increasing the relative abundance of relative abundance of faecalibaculum_rodentium, and promoting the production of short-chain fatty acids; down-regulating the levels of TLR4, phosphorylated IKKα/β, and NF-κB p65, and inhibiting the expression of the TLR4/NF-κB inflammatory signalling pathway; and restoring zonula occludens 1, Occludin and Claudin-1 and other tight junction proteins expression to repair the intestinal barrier function; inhibiting the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 [ 82 ].…”

Pulsed Electric Field Combined with Deep Eutectic Solvents Enhanced the Antiglycation Activity of Noni Flavonoid Extracts by Directionally Regulating Their Glycoside and Aglycone Proportions

“…Plant extracts are increasingly considered safer candidates for preventing glycation compared to synthetic compounds, as they have shown fewer adverse reactions in vivo and in vitro experiments. , Flavonoids, which are polyphenolic compounds highly abundant in plant extracts, exert satisfactory antiglycation activity . Flavonoid extracts from Chrysanthemum indicum, Teucrium polium, and Vaccinium vitisidaea were reported to inhibit the formation of products from different glycation stages, which may be related to their strong radical scavenging activity .…”

Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

“…This plant has been used in traditional Chinese medicine for thousands of years used to protect the liver, treat cancer, gastritis, enhance immunity, stimulate digestion, reduce blood sugar and blood fat. 1,2 In Vietnam, D. officinale has been found in the mountains and forests of Vinh Phu, Quang Tri, Quang Nam, Da Nang, Gia Lai, Lam Dong provinces. The previous studies reported terpenoids, 3 bibenzyl derivatives, 1–7 polysaccharides, 8–15 are the main components of this plants.…”

“…1,2 In Vietnam, D. officinale has been found in the mountains and forests of Vinh Phu, Quang Tri, Quang Nam, Da Nang, Gia Lai, Lam Dong provinces. The previous studies reported terpenoids, 3 bibenzyl derivatives, 1–7 polysaccharides, 8–15 are the main components of this plants. Some of which exhibited antitumor, 7,14,15 anti-inflammatory activities 8–13 and alleviates type 2 diabetes mellitus.…”