Discovery of new triterpene glycosides from <i>Dendrobium officinale</i> with their α-glucosidase and α-amylase inhibitory activity

Four undescribed spirostan glycosides, (25S)‐5α‐spirostan‐12‐one‐2α,3β‐diol‐3‐O‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (1), (25S)‐5α‐spirostan‐12‐one‐2α,3β‐diol‐3‐O‐β‐D‐galatopyranosyl‐(1→2)‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (2), (25S)‐5α‐spirostan‐12‐one‐2α,3β‐diol‐3‐O‐β‐D‐glucopyranosyl‐(1→2)‐[β‐D‐glucopyranosyl‐(1→3)]‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (3), and hecogenin 3‐O‐β‐D‐glucopyranosyl‐(1→3)‐[β‐D‐xylopyranosyl‐(1→2)]‐β‐D‐glucopyranosyl‐(1→4)‐[α‐L‐rhamnopyranosyl‐(1→2)]‐β‐D‐galactopyranoside (4), together with eleven known compounds (5‐15) were isolated from the branches and leaves of Tribulus terrestris. Their chemical structures were established through spectroscopic methods. including HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Preliminary biological evaluation on NO production inhibitory activity in LPS activated RAW 264.7 cells showed that compounds 1‐3, 5, and 6 had significant inhibitory effects with IC50 values ranging from 2.4 to 18.3 µM, compared to that of the positive control compound, dexamethazone (IC50 13.6 µM).

Tributelosides A−D: Four Undescribed Spirostan Glycosides Isolated from the Branches and Leaves of Tribulus terrestris with Their NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells

Van Quoc,

Huy Hoang,

Huu Tai

et al. 2024

Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity

Kiem,

Quoc,

Tai

et al. 2024

Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A‐E (1‐5), and three known ones (6‐8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Furostanols 1‐8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 µM, compared to that of the positive control compound, dexamethazone (IC50 13.6 µM).

Three Undescribed Furanoditerpenoids from the Tinospora crispa that Inhibit NO Production

Van Quoc,

Huu Tai,

Hai Yen

et al. 2024

Phytochemical study on the methanol extract of the stems of Tinospora crispa (L.) Hook.f. & Thomson led to the isolation of thirteen compounds including three undescribed cis‐clerodane‐type furanoditerpenoids (1‐3) and ten known ones (4‐13). Their chemical structures were determined by IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Compounds 2‐6 and 8 inhibited moderately NO production in LPS activated RAW 264.7 cell with the IC50 values of 83.5, 57.6, 75.3, 78.1, and 74.7 µM, respectively.