Chemical Constituents, Cytotoxic, Antioxidant and Cholinesterases Inhibitory Activities of Silene Compacta (Fischer) Extracts

Abstract

In Turkey, Silene species have been used as infusion in urinary bladder and biliary tract diseases in traditional medicine. Silene species have been also consumed as food in Anatolia and Europe. In this study, the phenolic, fatty acid and essential oil profiles and the cytotoxic, antioxidant and cholinesterases inhibitory activities, and total phenolic-flavonoid content of Silene compacta Fischer (SC) were studied. The essential oil and fatty acid compositions of S. compacta were determined by using GC/MS in the current study. The chemical composition of the methanol extract was determined using LC-MS/MS for quantitative and qualitative purposes. The major components of the essential oil and fatty acid were identified as α-selinene (12.4%) and palmitic acid (26.3%), respectively. The methanol extract (SCM: S. compacta methanol extract) which possessed the best activity in four tested antioxidant methods among the tested extracts exhibited very strong cholinesterases inhibitory activities. Additionaly, this extract indicated the highest cytotoxic effect against A549 cells. In the SCM extract, hesperidin and rutin, quinic and malic acids were quantified by LC-MS/MS as major contituents.

Trabzon-Düzköy İlçesi Yayla Çayırlarının Floristik Yönden İncelenmesi

“…Yıllık 40-80 santimetre uzunluğa kadar büyüyen tek yıllık, iki veya çok yıllık olup otsu karakterinde, 500-3500 m yüksekliklerdeki step, yamaçlar, çalılık alanlarda bulunmaktadır. Bitkide bulunan uçucu yağ ve yağ asidinin ana bileşenleri sırasıyla α-selinen (%12.4) ve palmitik asit (%26.3) olarak tanımlanmıştır (Boğa, 2017).…”

Antimicrobial Effect, Antioxidant Potential and Cytotoxic Activity of the Crude and Green Synthesized Silver Nanoparticles′ Extracts of Silene conoidea L. Leaves Growing in Egypt

“…Phytochemical investigation of genus Silene led to the isolation of several phytoecdysteroids, triterpene glycosides 27,28 , triterpene saponins 29 , volatile terpenoids, benzenoids, flavonoids 30 , anthocyanidins, amino acids 31 , sterols, fatty acids [32][33][34] , polysaccharides, sugars 35 , organic acids, microelements and vitamins 36,37 . Some species of genus Silene are used as ornamental plants, they are used in folk medicine as antiinflammatory, antimicrobial 38 , diuretic 39 , antipyretic, analgesic 40 , antitumor, immunomodulatory 41,42 and antioxidant 43 .…”