Chemical constituents from Chimaphila japonica Miq. and their chemotaxonomic significance

Yu, Yue; Liú, Dan; Elshafei, Alaa; Lang, Mingyue; Hu, Dandan; Sun, Yan‐Qiong; Dong-zhou, Kang; Zheng, Ming

doi:10.1016/j.bse.2023.104664

Cited by 3 publications

(1 citation statement)

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“…is a perennial herbaceous plant that has diuretic, astringent, analgesic, and other effects; and it can treat various conditions such as edema, hydrops, etc. [ 11 ]. At present, little research has been carried out on the chemical composition of the plant; the biological activity is mainly directed towards crude extracts, and the pharmacodynamic material basis is unclear.…”

Section: Introductionmentioning

confidence: 99%

Constituents of Chimaphila japonica and Their Diuretic Activity

Yu,

Hu,

Liu

et al. 2024

Molecules

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Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and compounds 9 and 10 were reported in C. japonica for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds 4, 7, and 11 exhibited potent diuretic activity. The modes of interaction between the selected compounds and the target diuretic-related WNK1 kinase were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential diuretic activities of metabolites in C. japonica.

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Section: Introductionmentioning

confidence: 99%