Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity

Shu, Penghua; Sun, Mengyuan; Li, Junping; Zhang, Lingxiang; Xu, Haichang; Lou, Yueyue; Ju, Zhiyu; Wei, Xialan; Wu, Wenming; Sun, Na

doi:10.1007/s11418-019-01359-8

Cited by 26 publications

(13 citation statements)

References 19 publications

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“…Three megastigmane sesquiterpenoids and their glycosides were isolated from the leaves (23)(24)(25). The glucose was substituted at the hydroxyl of C-3, wilsonol A (23) 44 had a 3hydroxy-1-butenyl side chain at C-6, while the glycoside 24 (ref. 44) and 25 (ref.…”

Section: Terpenoidsmentioning

confidence: 99%

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Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Liu

Gao

et al. 2022

Nat. Prod. Rep.

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Section: Terpenoidsmentioning

confidence: 99%

“…5 The structure of lignans from G. biloba. Natural Product Reports Review including 161-173; 25,44,53,57,68,98,[138][139][140] benzofuran neolignans, including 174-178; 44,57,98,140,141 benzo-cyclohexane neolignans, including 179-182; 25,44,98,138 and 8-O-4 0 neolignans, including 183 and 184. 25,44 Their structures are shown in Fig.…”

Section: Reviewmentioning

confidence: 99%

Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Liu

Gao

et al. 2022

Nat. Prod. Rep.

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“…Until recently, bilobalide was thought to be the only sesquiterpene lactone in G. biloba, but Dong et al announced a new bilobalide isomer in 2020 [28]. G. biloba also contains nor-terpenoids, including three nor-sesquiterpenoids discovered by Shu et al in G. biloba L. [29]. e chemical structures of terpenoids are shown in Figure 1.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Noor-E-Tabassum

Das

Lami

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity, antilipidemic, antimicrobial, antioxidant, antilipid peroxidation, antiplatelet, anti-inflammatory, hepatoprotective, antidepressant, antiaging, immunomodulatory, antihypertensive, and neuroprotective effects and is frequently used to treat neurological, cardiovascular, and respiratory diseases, such as tardive dyskinesia. Therefore, this review described the therapeutic applications of G. biloba. In addition to describing the therapeutic potential, this review also evaluates the chemical constituents, toxicity, adverse effect, synergistic effect, and the clinical studies of this plant which have been utilized for therapeutic benefits but have demonstrated other consequences. The capacity of G. biloba components to act as free radical scavengers is critical, and combining its extract with other plant extracts has been shown to synergistically boost antioxidant properties. G. biloba used long-term or at high doses that resulted in some adverse effects. Severe drug interactions have also been reported in both animals and humans when combined with other medications. The available data established from both preclinical and clinical studies confirm the potential of G. biloba plant extract in various diseases. Besides, the safety and efficacy of G. biloba continue to require verification through additional experimentation to guide medicinal use.

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“…The most available bioactive compounds present in this plant are flavonol glycosides (quercetin and catechin) and terpenoids (ginkgolides and bilobalides), which are reported as unique bioactive components of this tree due to their high neurocurative effects. The pharmacological effects as well as medicinal properties of this plant are due to the presence of terpenoids, flavonoids, and proanthocyanidins as reported by several scientists [ 5 ]. Experimental animal studies also discovered the mechanisms of action that have been postulated to reaffirm its pharmacological properties, ability to inhibit platelet-activating factor and enhance nitric oxide elimination from the body system.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model

Hassan

Ibrahim

Yusuf

et al. 2020

Journal of Toxicology

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Background. Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. Presently, treatment of these diseases is not effective and encounters many challenges due to the cost of drug and side effects. Thus, the search for the alternative agents to replace synthetic drugs is in high demand. Therefore, the aim of this study is to evaluate the anticholinesterase properties of Ginkgo biloba seed. Methods. The seed was extracted with 80% methanol. Toxicity studies and evaluation of anticholinesterase activities were carried out in adult Javanese medaka (Oryzias javanicus). Phytochemical study to identify the bioactive lead constituents of the crude extract was also carried out using high performance liquid chromatography (HPLC). Results. The result shows activities with high significant differences at P<0.001 between the treated and nontreated groups. A bioactive compound (vitaxin) was identified with the aid of HPLC method. Conclusion. The presence of bioactive compound vitaxin is among the major secondary metabolites that contribute to increasing activities of this plant extract. High anticholinesterase activities and low toxicity effect of this plant show its benefit to be used as natural medicine or supplements.

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Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity

Cited by 26 publications

References 19 publications

Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model

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