Chemical Constituents from<i>Marrubium alysson</i>

Saleh, M. R. I.; Sarg, Taha; Metwally, A. M.; Rakha, A. A.

doi:10.1055/s-2007-971702

Cited by 11 publications

(3 citation statements)

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“…Accordingly, 40 hits were recognized, where the majority of the identified compounds were flavonoids (16 compound). Previous reports on the chemical constituents of M. alysson L. revealed the isolation of a number of flavonoids including chrysoeriol, acacetin, acacetin-7-glucoside, diosmetin, diosmetin-7-rhamnoside, luteolin, luteolin-7-rutinoside, quercetin in addition to apigenin and its 7-glycosides [11,87].…”

Section: Discussionmentioning

confidence: 99%

Marrubium alysson L. Ameliorated Methotrexate-Induced Testicular Damage in Mice through Regulation of Apoptosis and miRNA-29a Expression: LC-MS/MS Metabolic Profiling

Abdelhameed

Ali

Elhady

et al. 2022

Plants

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Despite the efficient anti-cancer capabilities of methotrexate (MTX), it may induce myelosuppression, liver dysfunction and testicular toxicity. The purpose of this investigation was to determine whether Marrubium alysson L. (M. alysson L.) methanolic extract and its polyphenol fraction could protect mouse testicles from MTX-induced damage. We also investigated the protective effects of three selected pure flavonoid components of M. alysson L. extract. Mice were divided into seven groups (n = 8): (1) normal control, (2) MTX, (3) Methanolic extract + MTX, (4) Polyphenolic fraction + MTX, (5) Kaempferol + MTX, (6) Quercetin + MTX, and (7) Rutin + MTX. Pre-treatment of mice with the methanolic extract, the polyphenolic fraction of M. alysson L. and the selected pure compounds ameliorated the testicular histopathological damage and induced a significant increase in the serum testosterone level and testicular antioxidant enzymes along with a remarkable decline in the malondialdehyde (MDA) level versus MTX alone. Significant down-regulation of nuclear factor kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), p53 and miRNA-29a testicular expression was also observed in all the protected groups. Notably, the polyphenolic fraction of M. alysson L. displayed a more pronounced decline in the testicular levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and MDA, with higher testosterone levels relative to the methanolic extract. Further improvements in the Johnsen score, histopathological results and all biochemical assays were achieved by pre-treatment with the three selected pure compounds kaempferol, quercetin and rutin. In conclusion, M. alysson L. could protect against MTX-induced testicular injury by its antioxidant, anti-inflammatory, antiapoptotic activities and through the regulation of the miRNA-29a testicular expression. The present study also included chemical profiling of M. alysson L. extract, which was accomplished by LC-ESI-TOF-MS/MS analysis. Forty compounds were provisionally assigned, comprising twenty compounds discovered in the positive mode and seventeen detected in the negative mode.

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Section: Discussionmentioning

confidence: 99%

Marrubium alysson L. Ameliorated Methotrexate-Induced Testicular Damage in Mice through Regulation of Apoptosis and miRNA-29a Expression: LC-MS/MS Metabolic Profiling

Abdelhameed

Ali

Elhady

et al. 2022

Plants

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“…Although most of these compounds are also found in other plants, the substances produced by this genus, especially terpenes, phenylpropanoids and flavonoids ( Table 1), some of them with significant yields and biological effects, make the genus Marrubium an important source of potential phytotherapeutic agents. M. alysson L. antimicrobial steroids, flavonoids, glycoside flavonoids, diterpenes, triterpene acids and phenylpropanoids [13][14][15][16][17][18] M. alternidens spamolytic, hypotensive, colagogue, and sedative agents.…”

Section: Discussionmentioning

confidence: 99%

A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

Meyre‐Silva¹,

Cechinel‐Filho

2010

CPD

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The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors.

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“…40 Several studies on essential oil composition of Marrubium species are found in literature. [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Evaluating the naturally occurring volatile constituents in the essential oil of a plant would be of value in characterizing species within a genus. According to the valuable results from previous studies on Marrubium species, M. propinquum and M. parviflorum were selected for assessing chemical components in their essential oils.…”

Section: Introductionmentioning

confidence: 99%