Chemical constituents from Ibervillea lindheimeri (A. Gray) Greene

Figueroa-Hernández, José L.; Martínez‐Vázquez, Mariano

doi:10.1016/j.bse.2014.01.004

Cited by 4 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ese pools rendered a total of 84.37 g of EtOAc extract, corresponding to 1.14 ± 0.48% of the dry weight of the root (Table 1). In a previous study, a similar yield was reported [5].…”

Section: Extraction and Isolation Of Secondary Metabolites From I Lin...supporting

confidence: 79%

“…e identification of 1, 2, 3, and 4 was achieved by analyzing their 1 H, 13 C, and 2D nuclear magnetic resonance (NMR) spectra and comparing their physical and spectral data with published data [5,32,33].…”

Section: Extraction and Isolation Of Secondary Metabolites From I Lin...mentioning

confidence: 99%

“…In Mexico, the species Ibervillea lindheimeri from the family Cucurbitaceae, which is locally known as "wereque," grows [5]. is plant is a thin, creeping perennial vine with tendrils growing from a large thick caudex [6].…”

Section: Introductionmentioning

confidence: 99%

“…is plant is a thin, creeping perennial vine with tendrils growing from a large thick caudex [6]. An earlier chemical analysis of this species led to isolating 23,24dihydrocucurbitacin F,23,24-dihydrocucurbitacin D and its 2-O-β glucopyranosyl derivative; these compounds were isolated from the ethyl acetate extract [5]. Cucurbitacins are a group of triterpenoids isolated as bitter compounds from the Cucurbitaceae family species and are characterized by a tetracyclic cucurbitane nucleus skeleton 19-(10⟶9b)-abeo-10α-lanost-5-ene [7].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anti-Diabetic Effects of Cucurbitacins from Ibervillea lindheimeri on Induced Mouse Diabetes

Navia

Figueroa-Hernández

Rodríguez‐Zavala

et al. 2022

Journal of Chemistry

View full text Add to dashboard Cite

Mexico has a great tradition of using medicinal plants against diabetes. For example, species from the genus Ibervillea traditionally known as “wereque” in Mexican popular medicine have a long ethnobotanical history as anti-diabetic agents. Previous studies by our group indicated that ethyl acetate extract from Ibervillea lindheimeri (I. lindheimeri) roots reduced glucose in mice with chemically induced diabetes. In this work, the primary metabolites of the ethyl acetate extract of I. lindheimeri; 23,24-dihydrocucurbitacin D (1); 2-O-β glucopyranosyl-23,24-dihydrocucurbitacin D (2), and acetylated compounds (3) and (4) obtained from 1 and 2, respectively, were evaluated as anti-hyperglycemic agents in a murine model of chemically induced diabetes. Our results showed that cucurbitacins 1, 2, and 4 reduced glycemia in diabetic CD1 mice compared to the control diabetic group. In addition, the results suggest that compounds 1, 2, and 4 promote glucose transporter type 4 (Glut4) translocation to the plasma membrane (PM) mainly in epididymal adipose tissue (EAT), AMP-activated protein kinase (AMPK) activation in soleus muscle (SM) or dual activation of AMPK, and protein kinase B (AKT) in EAT in an insulin-independent manner when compared to controls. All results together indicate that the isolated cucurbitacins are responsible for the anti-diabetic properties of I. lindheimeri acting predominantly on adipose tissue and call attention to this species as a new source of anti-diabetic compounds.

show abstract

“…ese pools rendered a total of 84.37 g of EtOAc extract, corresponding to 1.14 ± 0.48% of the dry weight of the root (Table 1). In a previous study, a similar yield was reported [5].…”

Section: Extraction and Isolation Of Secondary Metabolites From I Lin...supporting

confidence: 79%

Section: Extraction and Isolation Of Secondary Metabolites From I Lin...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-Diabetic Effects of Cucurbitacins from Ibervillea lindheimeri on Induced Mouse Diabetes

Navia

Figueroa-Hernández

Rodríguez‐Zavala

et al. 2022

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…To discover potential antifeeding products, we evaluated a 95% ethanol extract of H . penxianensis , obtaining 10 new cucurbitane-type triterpene hemsleyacins A–J ( 1 – 10 ) and three known cucurbitane-type triterpenes, namely, dihydrocucurbitacin F 6 ( 11 ), scandenogenin D 7 ( 12 ), and jinfushanencin F 8 ( 13 ) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxy cucurbitane triterpenes from Hemsleya penxianensis tubers

Sun

Zhu

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Ten new cucurbitane triterpenoids, hemsleyacins A–J ( 1 – 10 ), together with three known cucurbitane triterpenoids, dihydrocucurbitacin F ( 11 ), scandenogenin D ( 12 ), and jinfushanencin F ( 13 ), were separated from ethanolic tuber extracts of Hemsleya penxianensis . The absolute configurations of the new compounds were established based on NMR, HRESIMS, and CD spectra. Compounds 7 and 10–12 were evaluated in terms of their antifeedant activity against Plutella xylostella larvae. The result showed that compound 10 exhibited potent antifeedant activity against P . xylostella larvae after 48 h of treatment. Furthermore, the MTT test showed that compound 11 exhibited potent inhibition toward the UMUC-3 and T24 cell lines with IC 50 values of 29.12 and 35.62 μM, respectively, compared to the positive control cisplatin IC 50 values of 8.27 and 13.72 μM. Western blot analysis revealed that compound 11 treatments substantially inhibited the phosphorylation of IκBα.

show abstract