Chemical constituents from Oldenlandia corymbosa L. of Thai origin

Noiarsa, Pawadee; Ruchirawat, Somsak; Otsuka, Hideaki; Kanchanapoom, Tripetch

doi:10.1007/s11418-007-0212-1

Cited by 29 publications

(10 citation statements)

References 13 publications

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“…By searching the known iridoid glucosides with an MW of 371 in P . scanddens and by comparing the chromatographic behavior with published data, the compound corresponding to peak 6 was tentatively identified as deacetyl asperuloside (Suomi et al ., ; Noiarsa et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction

Jiang

Jin

et al. 2011

Biomedical Chromatography

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Paederia scandens (Lour.) Merri. (Jishiteng in Chinese) is a Chinese traditional medicine widely used in treating various diseases. However, its active components have remained unknown. In the present study, a rapid and sensitive method by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-MSn) techniques was employed to investigate the absorbed constituents in rats after oral administration of Paederia scandens decoction. By comparing their MS data with those of authentic compounds and published data, a total of six compounds (paederosid, 1; paederosidic acid, 2; paederosidic acid methyl ester, 3; 6-hydroxy geniposide, 4; asperuloside, 5; and deacetyl asperuloside, 6) were identified in the P. scandens decoction samples. In addition, a total of seven compounds, including three iridoid glucosides and four of their metabolites, were identified in rat urine samples after administration. In addition, six compounds, including four iridoid glucosides and two of their metabolites, were identified in rat serum samples after administration. Our results significantly narrow the range of potentially active compounds in P. scandens decoction, and build a solid foundation for future research on its mechanism.

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Section: Resultsmentioning

confidence: 97%

Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction

Jiang

Jin

et al. 2011

Biomedical Chromatography

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“…It is reported to possess antioxidant [ 4 , 5 ], anti-inflammatory [ 6 ], hepatoprotective [ 7 , 8 ], antitumor [ 9 , 10 ], antimalarial [ 11 ] and anti-nociceptive [ 12 ] activities. Iridoids, carboxylic acids, flavonoids, phenolics and their derivatives, triterpenes, anthranquinones and coumarins were isolated from HC [ 13 , 14 , 15 ]. Iridoid glycosides were reported as the main constituents [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis

Wang

Lin

et al. 2018

Molecules

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Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD.

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“…Hedyotis corymbosa L. or Rumput Mutiara is one of natural resources which revealed to perform several anticancer properties (Sivapraksam, et al, 2014). Based on phytochemical studies on Hedyotis corymbosa L., several flavonoids, terpenoids, and glycosides were present, such as ursolic acid, oleanolic acid, and gamma sitosterol (Noiarsa, et al, 2008). extract, Previous study reported that Hedyotis corymbosa L. ethanolic extract showed significant anticancer activity on K562 human leukemia cell lines (Pandey, et al, 2012) and on WiDr colon cancer (Meiftasari, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells

Novitasari¹,

Handayani

Jenie

2018

Indones J Cancer Chemoprevent

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Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines. The study aims to investigate whether ethanolic extract of Hedyotis corymbosa L. (EEH) performs anticancer properties by inhibiting migration and metastasis on breast cancer cells. Cytotoxic evaluation by using MTT assay was carried out to determine EEH effect on 4T1 breast cancer cells, meanwhile to investigate the treatment of EEH in migration and metastasis inhibitory effect, scratch wound healing assay and gelatin zymography were conducted in this study. The data showed that EEH possessed cytotoxic activity with IC50 value of 400 μg/mL. Interestingly, migration inhibitory effect was shown up to 42 hours and the activity of MMP-9 was also decreased after the treatment with EEH. According to these findings, we suggest that Hedyotis corymbosa L. promotes another anticancer properties by inhibiting migration and metastasis towards breast cancer cells.Keywords : Hedyotis corymbosa L., cytotoxicity, migration, metastatic, 4T1 breast cancer cells

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Chemical constituents from Oldenlandia corymbosa L. of Thai origin

Cited by 29 publications

References 13 publications

Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction

Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis

Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells

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