Chemical constituents from rauvolfia verticillata and bioactivities research

Abstract

A new acridone alkaloid, named 9-hydroxynoracronycine (1), together with four known compounds, including coumarins, lignan, and indole alkaloid, was isolated and identified from the roots and rhizomes of Rauvolfia verticillata. The structure of the new compound was determined by spectroscopic means (UV, IR, MS, and NMR). The acridone alkaloid and coumarins were identified as new constituents of Rauvolfia genus. The cytotoxic activities of the new compound were tested against human breast cancer cell line MCF-7 and human promyelocytic leukemia HL-60. Results showed that compound 1 decreased MCF-7 cell proliferation in a statistically IC 50 significant manner at 102.8 Pmol/L. In addition, compound 1 exhibited moderate small intestine smooth muscle relaxation.

Natural-Derived Polysaccharides From Plants, Mushrooms, and Seaweeds for the Treatment of Inflammatory Bowel Disease

“…R. verticillata belongs to the Apocynaceae family and is mainly distributed in China and Vietnam. Its roots and leaves are used for medicinal purposes including treating hypertension, hyperthermia, insomnia, and so on ( Hong et al, 2012 ). Miao et al (2019) obtained a pectic polysaccharide PP from the rootstocks of R. verticillata and found that PP treatment attenuated the overall physical activity, DAI, and morphological damage in DSS-treated colitis mice.…”

Three new compounds from the bark of Antiaris toxicaria

“…The other nine known compounds were identified as xanthyletin (4) (Hong et al, 2012), seselin (5) (Hong et al, 2012), umbelliferone (6) (Olennikov et al, 2012), 7-demethylsuberosine (7) (Kang et al, 2001), 8-hydroxy-7-methoxy-6-prenylcoumarin (8) (Filho et al, 1972), vaginol (9) (Zou et al, 2005), antiarsin B (10) (Jiang et al, 2009), antiarone K (11) (Shi et al, 2014), and antiarone F (12) (Hano et al, 1990a) by comparison of their physical and spectroscopic properties with those reported in the literatures.…”

Alkaloids and Lignans from the Aerial Parts of Rauvolfia tetraphylla Inhibit NO Production in LPS‐activated RAW 264.7 Cells

“…[1] The R. tetraphylla species has been reported to exhibit a variety of pharmacological effects such as antibacterial, antioxidant, anti-inflammatory, and cytotoxic activities. [2,6] This paper reported the isolation and structure determination of three new (1-3) together with thirteen known compounds (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) from the aerial parts of R. tetraphylla (Figure 1). Their nitric oxide production inhibition in LPS-activated RAW 264.7 cells were also screened and discussed herein.…”

“…[1] Phytochemical investigations on Rauvolfia species indicated that alkaloids (indole, yohimbine, ajimaline, ajmalicine, reserpine, deserpidine compounds), flavonoids, and lignans are the main component of this plant, which showed potential anti-inflammatory activity. [1][2][3][4][5][6] R. tetraphylla is a pubescent, ever-green shrub with woody stem and reaching a height of 4-6 feet, with many branches. Leaves are unequal, 5-9 x 3-4 cm, elliptic-ovate, acute at apex usually found in whorls of four.…”