Chemical constituents from the fruiting bodies of Phellinus igniarius

Abstract

A new tirucallane-type triterpenoid igniarine (1), and four known compounds meshimakobnol A (2), meshimakobnol B (3), ergosterol (4) and ergosterol peroxide (5), were purified from the methanol extracts of the fruiting bodies of Phellinus igniarius (DC. ex Fr.) Quél. The structure of 1 was elucidated using a combination of 1D and 2D NMR techniques and HR-ESI-MS analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumour cell lines and part of the tested compounds demonstrated weak cytotoxicity.

Chemical Constituents of the Ethyl Acetate Extract of the Fruit Bodies of Phellinus Gilvus

“…Previously, compounds which were purified from Vietnamese Phellinus sp. are likely to exhibit broad, non-specific activities in biological systems [12][13][14][15]. Specifically, compounds 2 and 3 exhibited moderate cytotoxicity to KB cell lines with their IC 50 value of 10.72 and 12.12 g/mL, respectively [16].…”

“…1 H NMR (500 MHz, DMSO-d 6 ): δ H 3.85 (6H, 3,6-OCH 3 ) 13. C NMR (125 MHz, DMSO-d 6 ): δ C 60.9 (3,6-OCH 3 ), 126.9 (C-1, C-2, C-4, C-5), 150.0 (C-3, C-6).Compound 2: 1 H NMR (500 MHz, CDCl 3 ): δ H 0.63 (3H, s, H-19), 0.83 (3H, d, J = 7.5 Hz, H-26), 0.84 (3H, d, J = 7.0 Hz, H-27), 0.92 (3H, d, J = 6.5 Hz, H-28), 0.95 (3H, s, H-18), 1.04 (3H, d, J = 6.5 Hz, H-21), 3.61, (1H, m, H-3), 2.46 (1H, m, H-4), 5.16 (1H, m, H-22), 5.23 (1H, m, H-23), 5.38 (1H, m, H-7), 5.57 (1H, dd, J= 2.5, 5.0 Hz, H-6).…”

Secondary Metabolites From Higher Fungi in Vietnam: Discovery, Chemodiversity, and Bioactivity

“…The species of Phellinus genus in Viet Nam including P.igniarius, P.gilvus, P.baumii, and P.pini were studied for their chemical composition. Their triterpenoid composition has also been investigated (16)(17)(18)(19), showing that their structures mainly possess a tirucallane-type triterpenoid basic skeleton [18 -20]. Most of them contain 30 atoms.…”

“…Ergosterol (27) and ergosterol peroxides (28) are steroids isolated mainly from most of the Vietnamese macrofungi [13-16, 18, 19, 22-25]. This is also easily explained because these two compounds are structural components of the cell membrane of fungi.…”

A rapid analysis of antioxidants in Sanghuangporus baumii by online extraction-HPLC-ABTS

“…2,3 Modern researches have conrmed that S. baumii mainly contains polysaccharides, avonoids, triterpenoids and pyranone compounds with various biological activities, such as anti-tumor, anti-oxidation, anti-inammatory, immunomodulatory and hypoglycemic. [4][5][6][7] In the human body, reactive oxygen free radicals participate in numerous biological activities (immunity and signal transduction processes, etc.). The overproduction of active oxygen free radicals has a destructive effect, leading to a variety of diseases, such as heart disease, Alzheimer's disease, and tumors, by causing an oxidative damage to the normal cells and tissues.…”