Chemical constituents from the roots of Acanthus ilicifolius var. xiamenensis

Huang, Mingyu; Zhong, Lin-Jing; Wang, Fei; Liu, Quan-Yu; Zhang, Yonghong

doi:10.1016/j.bse.2014.03.006

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…Endophytic fungi of mangrove plants may include one to several taxa that are only adapted to each of these plant species (Schulz and Boyle 2005 ). The largest area and highest diversity of mangrove region are found in Asia (FAO 2007 ), suggesting that there is a high diversity of endophytic fungi in Asia, representing an untapped resource for bioactivity screening (Huang et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

et al. 2019

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BackgroundAcanthus ilicifolius var. xiamenensis (Acanthaceae) is an old world mangrove species and has long been used as a folk remedy for treating various ailments in traditional medicine. The nature source of A. ilicifolius var. xiamenensis is now in short supply because of the urban development and habitat destruction. To better utilize this resource, biodiversity and bioactivity of endophytic fungi isolated from A. ilicifolius var. xiamenensis were investigated.ResultsA total of 168 fungal isolates were cultured from leaves and stems of the mangrove plant collected in January (winter) and July (summer) 2014 at Kinmen County, Taiwan. Spent culture extract of 28 isolates were found to have bioactivities against one of the following pathogenic microorganisms: the bacteria Bacillus subtilis, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) and the fungi Candida albicans and Cryptococcus neoformans. These positive extracts were mostly active against the Gram-positive bacteria and C. albicans. Corynespora cassiicola NTOU4889 and Xylaria sp. NTOU4900 inhibited growth of all 3 test bacteria whereas Phellinus noxius NTOU4917 inhibited both test fungi. A further anti-inflammatory study of culture extracts of these 28 isolates revealed that extracts with a high iNOS inhibition caused a low viability of cells, and those with a low iNOS inhibition had a high cell viability. Three extracts showed low cytotoxicity (i.e. > 100% cell viability) and high iNOS inhibition (< 15% of NO production) of cells and they were Phoma sp. 2 NTOU4338, Nodulisporium sp. NTOU4868 and Guignardia sp. NTOU4871.ConclusionThese results indicate that the endophytic fungi associated with A. ilicifolius var. xiamenensis can be a potential source of novel natural active substance.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

et al. 2019

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“…The present study in addition to previously reported studies (Bandaranayake, 2002;Huo et al, 2005;Raut and Khan, 2012;Singh and Aeri, 2013;Huang et al, 2014;Nguyen et al, 2015) suggest that mangroves are a rich source of secondary metabolites probably because they grow and survive under very hostile environmental conditions (high salinity, low nutrition, low oxygen conditions of waterlogged mud and high solar radiation during low tide) (Kathiresan and Bingham, 2001). These naturally occurring bioactive constituents (eg-phenolic compounds) are majorly known to play an important role in the mechanism of anticancer (Babu et al, 2002;Bunyapraphatsara et al, 2003;Van Kiem et al, 2008;Ravikumar and Gnanadesigan, 2011;Firdaus et al, 2013).…”

Section: Cytotoxicity and Apoptosis Studies On Hep G2 Cancer Cell Linementioning

confidence: 60%

The antioxidant, anticancer and anticoagulant activities of Acanthus ilicifolius L. roots and Lumnitzera racemosa Willd. leaves, from southeast coast of India

2017

J App Pharma Sci

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The present study was designed to evaluate and determine the phytochemical composition, antioxidant, anticancer and anticoagulant activities of the aqueous extracts of Acanthus ilicifolius roots and Lumnitzera racemosa leaves from Pichavaram mangrove forest, Tamil Nadu, India based on folklore knowledge. The preliminary phytochemical screening revealed the presence of the following classes of bioactive compounds: phenols, flavonoids, alkaloids, terpenoids, sterols, tannins, carbohydrates, cardiac glycosides, saponins and quinones. The total phenolic content was reported much higher as compared to the total flavonoid content mainly in the leaf extract of L.racemosa. This mostly contributes to the antioxidant power of the extracts, which is affirmed by the IC50 values of the crude extracts in the DPPH assay, which was lower than the ABTS assay. The FRAP assay also exhibited a consistent increase in reducing ability with increase in the concentration which is indicative of the extract's antioxidant potential. The extracts were also reported to exhibit in vitro cytotoxicity and apoptosis inducing ability in Hep G2 cancer cells. And the anticoagulant study conducted provided a first hand report for the plants exhibiting the property. However, further studies must be conducted for secondary metabolite profiling to decipher and clarify the compound(s) responsible for the reported activities of the plant crude extracts.

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“…Benzoxazinones were isolated from the Acanthus ilicifolius. [7,8] and might provide a chemotaxonomic evidence to support the morphological classification of Acanthus ilicifolius. We think the endophytic fungi play important roles in the process of growth of host plants and also the secondary metabolites produced by fungi might have a close relationship with the metabolic pathways of host plants.…”

mentioning

confidence: 88%

A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp

Zhong

Yuan

et al. 2015

Natural Product Communications

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A new benzodiazepine alkaloid containing terminal cyano group has been isolated from a mangrove endophytic fungus, Penicillium 299#. Structure elucidation was determined by 1D and 2D NMR spectroscopy and the absolute configuration was determined by electronic circular dichroism (ECD). The new compound showed no cytotoxic activities in vitro against human cancer lines MDA-MB-435, HepG2, HCT-116, and Calu-3.

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Chemical constituents from the roots of Acanthus ilicifolius var. xiamenensis

Cited by 9 publications

References 10 publications

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

The antioxidant, anticancer and anticoagulant activities of Acanthus ilicifolius L. roots and Lumnitzera racemosa Willd. leaves, from southeast coast of India

A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp

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