“…Extracts of some of Daphne species are widely used for treating cancers, and various compounds isolated from these plants have shown cytotoxic, antimicrobial and antileukemic activities (14,15,18). Different classes of secondary metabolites have been isolated from species belonging to this genus including flavonoids, coumarins, and diterpenoids (1,23,25,26,29). Previous studies have shown that coumarins daphnetin, daphnin, daphnoretin, umbelliferon, and 4-hydroxy-coumarin exhibited good antimicrobial activity (4,5,7,8).…”