Chemical constituents involved in e-cigarette, or vaping product use-associated lung injury (EVALI)

Muthumalage, Thivanka; Friedman, Michelle; McGraw, Matthew D.; Friedman, Alan E.; Rahman, Irfan

doi:10.1101/2020.01.14.905539

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…The presence of silicon oils (siloxanes) is also a cause for concern. Inhalation of high concentrations of silicon compounds can lead to respiratory irritation, leukocytosis, and may contribute to the development of pulmonary edema and lesions (Jean and Plotzke, 2017;Muthumalage et al, 2020). While the qualitative nature of this data precludes us from making stronger associations, this data shows some evidence of exposure to chemicals capable of inducing cell growth arrest and senescence.…”

Section: Discussionmentioning

confidence: 85%

E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging

et al. 2020

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Electronic cigarette (e-cig) usage has risen dramatically worldwide over the past decade. While they are touted as a safe alternative to cigarettes, recent studies indicate that high levels of nicotine and flavoring chemicals present in e-cigs may still cause adverse health effects. We hypothesized that an e-liquid containing a mixture of tobacco, coconut, vanilla, and cookie flavors would induce senescence and disrupt wound healing processes in pulmonary fibroblasts. To test this hypothesis, we exposed pulmonary fibroblasts (HFL-1) to e-liquid at varying doses and assessed cytotoxicity, inflammation, senescence, and myofibroblast differentiation. We found that e-liquid exposure caused cytotoxicity, which was accompanied by an increase in IL-8 release in the conditioned media. E-liquid exposure resulted in elevated senescence-associated beta-galactosidase (SA-β-gal) activity. Transforming growth factor-β1 (TGF-β1) induced myofibroblast differentiation was inhibited by e-liquid exposure, resulting in decreased α-smooth muscle actin and fibronectin protein levels. Together, our data suggest that an e-liquid containing a mixture of flavors induces inflammation, senescence and dysregulated wound healing responses.

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Section: Discussionmentioning

confidence: 85%

E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging

et al. 2020

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“…Among the cases that reported product source, most (78%) acquired products from informal sources such as a dealer or friend. While vitamin E acetate was strongly associated with the EVALI outbreak (5), other vape product additives may have contributed to the acute lung injuries (6). The CDC's initial recommendation to abstain from using any e-cigarette or vaping device, along with media coverage of the outbreak (7,8,9), may have contributed to misperceptions about EVALI (10) and ENDS health risks (11).…”

Section: Introductionmentioning

confidence: 99%

Cannabis Vape Product Sales in California Following CDC's Initial Advisory About Lung Injuries

Timberlake,

Bruckner,

Pechmann

et al. 2024

Cannabis and Cannabinoid Research

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Introduction:The 2019 outbreak of e-cigarette or vaping product useassociated lung injury (EVALI) is believed to have been caused by vitamin E acetate, an additive used in some cannabis vaporizer products. Previous studies have primarily focused on changes in sales of electronic nicotine delivery systems (ENDS) following the initial advisory issued by the Centers for Disease Control (CDC) on August 17, 2019. The present study is intended to examine variation by age groups in sales of regulated cannabis vape products in the state of California before, during and after the outbreak.Methods: Weekly sales revenue of cannabis vape products (1/1/2018-12/31/2020) were obtained from a sample of licensed California adultuse cannabis retailers. An interrupted time series analysis, using ARIMA methods, was employed to estimate changes in the sales and market share of cannabis vape products in the weeks following the CDC advisory.Results: The total volume of regulated cannabis vape product sales increased substantially over the three-year study period (2018)(2019)(2020). However, the market share of cannabis vape products declined in both younger adults (23-25 years) and older adults (>25 years) immediately following the advisory, rebounding to pre-EVALI levels only for younger adults. For older adults, a 20% decline in market share of cannabis vape products was observed over the twelve weeks following the EVALI advisory.Conclusions: The differential age effect on sales may reflect concerns regarding health effects of cannabis vaping products and greater awareness of the outbreak amongst older adults. Findings highlight the importance of informing consumers about health risks associated with using cannabis vape products acquired from regulated versus illicit

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Toxic ketene gas forms on vaping vitamin E acetate prompting interest in its possible role in the EVALI outbreak

Strongin

2020

Proc. Natl. Acad. Sci. U.S.A.

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Chemical constituents involved in e-cigarette, or vaping product use-associated lung injury (EVALI)

Cited by 8 publications

References 23 publications

E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging

E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging

Cannabis Vape Product Sales in California Following CDC's Initial Advisory About Lung Injuries

Toxic ketene gas forms on vaping vitamin E acetate prompting interest in its possible role in the EVALI outbreak

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