Chemical Constituents Isolated from <i>Bletilla striata</i> and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Bae, Joon Young; Lee, Jin Woo; Jin, Qinghao; Jang, Hari; Lee, Dong‐Ho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Lee, Moon Soon; Hwang, Bang Yeon

doi:10.1002/cbdv.201600243

Cited by 18 publications

(5 citation statements)

References 22 publications

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“…They are important secondary metabolites in plants because of the protection they offer against insects, viruses, and bacteria (Heleno et al, 2015). Consumption of phenolic acid-rich food could assist with accelerating the elimination of oxygen free radicals in the body, which would protect cells (Bae et al, 2016). Twelve phenolic acids ( 137–148 ) have been obtained from B. striata , and their structures are shown in Figure 10 .…”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

Pan

Chen

2019

Front. Pharmacol.

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Bletilla striata is a plant from the Orchidaceae family that has been employed as a traditional Chinese medicine (TCM) for thousands of years in China. Here, we briefly review the published studies of the last 30 years that were related to chemical constituents, pharmacologic activities, and clinical applications of B. striata. Approximately 158 compounds have been extracted from B. striata tubers with clarified molecular structures that were classified as glucosides, bibenzyls, phenanthrenes, quinones, biphenanthrenes, dihydrophenanthrenes, anthocyanins, steroids, triterpenoids, and phenolic acids. These chemicals support the pharmacological properties of hemostasis and wound healing, and also exhibit anti-oxidation, anti-cancer, anti-viral, and anti-bacterial activities. Additionally, various clinical trials conducted on B. striata have demonstrated its marked activities as an embolizing and mucosa-protective agent, and its application for use in novel biomaterials, quality control, and toxicology. It also has been widely used as a constituent of many preparations in TCM formulations, but because there are insufficient studies on its clinical properties, its efficacy and safety cannot be established from a scientific point of view. We hope that this review will provide reference for further research and development of this unique plant.

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Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

Pan

Chen

2019

Front. Pharmacol.

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“…B. striata was mainly applied in astringent hemostasis, detumescence and myogenesis, and these traditional applications were closely related their anti-inflammatory and anti-oxidative activities. Bibenzyl, dihydrophenanthrene, and diphenanthrene compounds contained in this plant are known to have various biological activities in wound healing in addition to their antioxidant activities ( Wei and Hui, 2015 , He et al, 2017 , Bae et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Lung protective effects of dietary malate esters derivatives from Bletilla striata against SiO2 nanoparticles through activation of Nrf2 pathway

Zhou

Chang

et al. 2023

Chinese Herbal Medicines

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“…Bletilla striata, a perennial herb of the genus Bletilla (Orchidaceae), is mainly distributed in China, including the Guangxi, Yunnan, and Sichuan provinces [6]. Its dry tubers have been commonly used in traditional medicine for centuries to treat various diseases, including lung disorders, gastrointestinal disorders, traumatic bleeding, burns, and ulcers [7,8]. It has been reported that B. striata contains stilbenes (bibenzyls and phenanthrenes) and polysaccharides [9,10].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Stilbenes from Bletilla striata against Cutibacterium acnes and Its Effect on Cell Membrane

Yu,

Sun,

Peng

et al. 2023

Microorganisms

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The abnormal proliferation of Cutibacterium acnes is the main cause of acne vulgaris. Natural antibacterial plant extracts have gained great interest due to the efficacy and safety of their use in skin care products. Bletilla striata is a common externally used traditional Chinese medicine, and several of its isolated stilbenes were reported to exhibit good antibacterial activity. In this study, the antimicrobial activity of stilbenes from B. striata (BSS) against C. acnes and its potential effect on cell membrane were elucidated by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), bacterial growth curve, adenosine triphosphate (ATP) levels, membrane potential (MP), and the expression of genes related to fatty acid biosynthesis in the cell membrane. In addition, the morphological changes in C. acnes by BSS were observed using transmission electron microscopy (TEM). Experimentally, we verified that BSS possessed significant antibacterial activity against C. acnes, with an MIC and MBC of 15.62 μg/mL and 62.5 μg/mL, respectively. The growth curve indicated that BSS at 2 MIC, MIC, 1/2 MIC, and 1/4 MIC concentrations inhibited the growth of C. acnes. TEM images demonstrated that BSS at an MIC concentration disrupted the morphological structure and cell membrane in C. acnes. Furthermore, the BSS at the 2 MIC, MIC, and 1/2 MIC concentrations caused a decrease in the intracellular ATP levels and the depolarization of the cell membrane as well as BSS at an MIC concentration inhibited the expression of fatty acid biosynthesis-associated genes. In conclusion, BSS could exert good antimicrobial activity by interfering with cell membrane in C. acnes, which have the potential to be developed as a natural antiacne additive.

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Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Cited by 18 publications

References 22 publications

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

Lung protective effects of dietary malate esters derivatives from Bletilla striata against SiO2 nanoparticles through activation of Nrf2 pathway

Antimicrobial Activity of Stilbenes from Bletilla striata against Cutibacterium acnes and Its Effect on Cell Membrane

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