Chemical constituents of Algerian mandarin (<i>Citrus reticulata</i>) essential oil by GC-MS and FT-IR analysis

Boughendjioua, Hicham; Mezedjeri, Nour El Houda; Idjouadiene, Ilhem

doi:10.2478/cipms-2020-0032

Cited by 20 publications

(5 citation statements)

References 16 publications

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“…The main components were limonene (67.04%), -terpinene (15.50%), and -pinene (2.75%). Sesquiterpene hydrocarbons accounted for a minor quantity (3.26%), where l-caryophyllene was the main constituent 53 .…”

Section: Resultsmentioning

confidence: 99%

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Elmaidomy,

Abdel-Maqsoud,

Tammam

et al. 2023

Sci Rep

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The current study investigated the scabicidal potential of Egyptian mandarin peel oil (Citrus reticulata Blanco, F. Rutaceae) against sarcoptic mange-in-rabbits. Analysis of the oil's GC–MS identified a total of 20 compounds, accounting for 98.91% of all compounds found. Mandarin peel oil topical application improved all signs of infection, causing a scabicidal effect three days later, whereas in vitro application caused complete mite mortality one day later. In comparison to ivermectin, histopathological analysis showed that the epidermis' inflammatory-infiltration/hyperkeratosis-had disappeared. In addition to TIMP-1, the results of the mRNA gene expression analysis showed upregulation of I-CAM-1-and-KGF and downregulation of ILs-1, 6, 10, VEGF, MMP-9, and MCP-1. The scabies network was constructed and subjected to a comprehensive bioinformatic evaluation. TNF-, IL-1B, and IL-6, the top three hub protein-coding genes, have been identified as key therapeutic targets for scabies. From molecular docking data, compounds 15 and 16 acquired sufficient affinity towards the three screened proteins, particularly both possessing higher affinity towards the IL-6 receptor. Interestingly, it achieved a higher binding energy score than the ligand of the docked protein rather than displaying proper binding interactions like those of the ligand. Meanwhile, geraniol (15) showed the highest affinity towards the GST protein, suggesting its contribution to the acaricidal effect of the extract. The subsequent, MD simulations revealed that geraniol can achieve stable binding inside the binding site of both GST and IL-6. Our findings collectively revealed the scabicidal ability of mandarin peel extract for the first time, paving the way for an efficient, economical, and environmentally friendly herbal alternative for treating rabbits with Sarcoptes mange.

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Section: Resultsmentioning

confidence: 99%

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Elmaidomy,

Abdel-Maqsoud,

Tammam

et al. 2023

Sci Rep

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“…Kinokuni), Xunwu mandarins (Citrus reticulata), and limonene was the predominate compound for all citrus EOs [67]. Boughendjioua et al [68] recorded the presence of 28 compounds in Algerian mandarin (Citrus reticulata) essential oil, constituting mainly Dlimonene (85.10%), sabinene (2.49%), linalyl acetate (2.00%), copaene (1.80%), and α-pinene (1.75%). In Tunisia, [69] identified 37 compounds from C. aurantium EO, of which limonene was the most abundant (62.2%) and recorded the antimicrobial activity against a panel of pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Environment-Friendly Control Potential of Two Citrus Essential Oils against Aphis punicae and Aphis illinoisensis (Hemiptera: Aphididae)

et al. 2022

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Aphids are serious pests of a wide range of agricultural crops, including pomegranates and grapevines. In addition, due to the negative environmental impacts of chemical insecticides, these pests are developing important resistance against aphicides. Therefore, one alternative method to control aphids is the use of essential oils (EO). The present study aimed to evaluate the insecticidal activity of Citrus aurantium and C. reticulata peel EO at different concentrations and with different exposure periods to pomegranate and grapevine aphids, Aphis punicae and A. illinoisensis via the topical application method under laboratory conditions. The results reveal that C. aurantium L. EO had greater toxicity against pomegranate and grapevine aphids, with LC50 of 0.37 and 0.82 μL/mL, respectively, at 48 h after application. The highest repellence effect was estimated for C. aurantium EO, at 2.5 μL/cm2, on A. punicae, with a value of 100% after an exposure time of 3 h, in contrast to the 88% repellence estimated for A. illinoisensis. The GC-MS investigation of both essential oils identified limonene, 3-carene, pinene, and p-cymene as active substances that could be attributed to the effects observed. Overall, our results offer a potential tool to control the two aphid species and could help in the development of integrated insect management in pomegranate and grapevine fields.

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“…Not surprisingly, some of the most active terpenes that we identified binding OR19A1 (Figure 3B) are part of the essential oil content from the mandarin citrus plant Citrus reticula. Among these terpenoids, α-humulene, β-myrcene, and γ-terpinene are present in low percentages (0.06-0.11%), α-pinene is one among the most abundant (1.75%), and D-limonene is the most abundant (85.1%) (Boughendjioua et al, 2021). Among various Californian crops, Citrus reticulata represents an alternative ovipositional and/ or reproductive host for D. suzukii, on which fruits high percentages of eggs develop to adults (Wang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster

Pettersson,

Cattaneo

2024

Front. Mol. Biosci.

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In insects, antennal ionotropic receptors (IRs) and odorant receptors (ORs) are among the main sensors of olfactory cues. To functionally characterize the subunits from these receptors, the use of ab3A neurons from transgenic Drosophila melanogaster represented one of the most powerful tools, allowing the identification of ligands (deorphanization) and decrypting their pharmacological properties. However, further investigation is needed to shed light on possible metabotropic functionalities behind insect olfactory receptors and test potentials from the up-to-now-used empty neuronal systems to express subunits belonging to variegate receptor classes. In this project, we adopted the most updated system of Drosophila ab3A empty neurons to test various olfactory receptors, ranging from human ORs working as metabotropic G-protein coupled receptors to insect ionotropic IRs and ORs. Testing transgenic Drosophila expressing human ORs into ab3A neurons by single sensillum recording did not result in an OR response to ligands, but it rather re-established neuronal spiking from the empty neurons. When transgenic D. melanogaster expressed ionotropic IRs and ORs, both heterologous and cis-expressed IRs were non-functional, but the Drosophila suzukii OR19A1 subunit responded to a wide asset of ligands, distinguishing phasic or tonic compound-dependent effects. Despite the use of Drosophila ab3A neurons to test the activation of some metabotropic and ionotropic receptor subunits resulted non-functional, this study deorphanized a key OR of D. suzukii demonstrating its binding to alcohols, ketones, terpenes, and esters.

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Chemical constituents of Algerian mandarin (Citrus reticulata) essential oil by GC-MS and FT-IR analysis

Cited by 20 publications

References 16 publications

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies

Environment-Friendly Control Potential of Two Citrus Essential Oils against Aphis punicae and Aphis illinoisensis (Hemiptera: Aphididae)

Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster

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