Chemical Constituents of Gentiana Macrophylla Pall. From Shaanxi

Abstract

A novel amide, qinjiaoamide and a novel iridoid, erythrocentaurin acid, together with seven known compounds [erythrocentaurin (3), roburic acid (4), oleanolic acid (5), gentiopicroside (6), swertiamarine (7), sweroside (8), and 6'-O-β-Dglucosylgentiopicroside (9)], were isolated from the root of Gentiana macrophylla Pall. from Shaanxi Province, China. The novel compounds were identified as N-pentacosyl-2-carboxy-benzoyl amide (1) and 5-carboxyl-3,4-dihydrogen-1H-2benzopyran-1-one (2), on the basis of spectroscopic (UV, IR, 1D-and 2D-NMR) and mass spectrometric data. Among the known compounds, erythrocentaurin (3) was isolated from the genus Gentiana for the first time.

Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol‐induced gastric mucosal injury in mice

“…Gentiopicroside (≥98%) was prepared from G. macrophylla Pall. as the method reported previously (Sun & Shang, ), and the molecular structure of gentiopicroside was confirmed in our previous report (Chen & Sun, ) as shown in Figure c. Absolute ethanol was purchased from Tianjin TianLi Chemical Reagent Co., Ltd (Tianjin, China).…”

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation

“…The isolated compounds were identified by comparison of their NMR and mass spectra with published data. Acetyl-11-keto-β-boswellic acid, β-boswellic acid, acetyl-α-boswellic acid, acetyl-β-boswellic acid [17, 18], betulinic acid [19], senkyunolide O [20], roburic acid [21], phenethyl trans -ferulate [22], and cryptotanshinone [23] were isolated and identified based on published procedures. All the COX ligands for testing were >95% pure by LC-MS. All other chemicals and solvents were ACS reagent grade, unless stated otherwise.…”

The effect of elicitors on oleanolic acid accumulation and expression of triterpenoid synthesis genes in Gentiana straminea

“…Gentiana straminea Maxim is a Chinese herbal medicinal plant native to the Qinghai-Tibet plateau, a high altitude region characterized by frequent extremes of cold temperature, high rainfall, and strong UV-B radiation. Its medicinal value is due to the compounds oleanolic acid, loganic acid, gentiopicroside, swertiamarin, and roburic acid (Chen et al 2005). Oleanolic acid (OA) is a pentacyclic triterpenoid associated with anti-hepatitis, anti-inflammatory, and anti-carcinoma activity (Laus 2004).…”