Chemical Constituents of Plants from the Genus Ixora

Abstract

Ixora is a genus of ca. 400 species in the family Rubiaceae. Since the 1940s, eighty-one compounds including phenolics, peptides, terpenoids, and sterols have been isolated from six species of the genus Ixora. Pharmacological studies have shown that these compounds and extracts from the Ixora genus have extensive activities, such as antitumor, chemoprotective, and antioxidant activities. In this review, we summarize the phytochemical progress and list the compounds isolated from the genus Ixora. The biological activities of this genus are also covered.

Chemovariation and antibacterial activity of extracts and isolated compounds from species of Ixora and Greenea (Ixoroideae, Rubiaceae)

“…Three known compounds (scopoletin, isofraxidin, and geniposidic acid) were detected and isolated from the extracts of Ixora and Greenea species. Scopoletin ( 1 ) is a widely distributed coumarin found in a number of plant families such as Rutaceae and Apiaceae (Jain & Joshi, 2012), Clusiaceae (Marcondes et al, 2015), Convolvulaceae (Sood, Pradhan & Biswasroy, 2014; Khan & Hossain, 2015; Ojha, Mishra & Mishra, 2016), Solanaceae (Valizadeh et al, 2014), Asteraceae (Adams, Efferth & Bauer, 2006), Burseraceae (Mogana, Teng-Jin & Wiart, 2013), Asclepiadaceae (El-Demerdash et al, 2009), and Rubiaceae (Swe, 2008; Mohammed et al, 2013; Chen, Zhang & Chen, 2016). Isofraxidin ( 2 ) is found in species of Araliaceae (Maruyama et al, 2008; Yamazaki & Tokiwa, 2010; Bai et al, 2011; Lee et al, 2013), Asteraceae (Kwak, Lee & Schmitz, 2001; Gliszczyńska & Brodelius, 2012; Yim et al, 2017), Apiaceae (Yim et al, 2017), Simaroubaceae (Hwang et al, 2012), Rutaceae (Brown et al, 1988), Chloranthaceae (Niu et al, 2012; Li et al, 2016), and Rubiaceae (De Araújo et al, 2012).…”

“…Thus, each plant part might possess different bioactive compounds that allow for different applications. To date, a few phytochemical studies of Ixora species have reported the presence of alkaloids, anthraquinones, phenolics, peptides, terpenoids, sterols, and iridoid glycosides (Chen, Zhang & Chen, 2016; Usha, Reginald & Immanuel, 2016). However, while there are several reports on the biological activities of extracts from Ixora species, only a handful of studies have identified their bioactive compounds.…”