Chemical Constituents of Plants from the Genus <i>Paris</i>

Wei, Jinchao; Gao, Wenyuan; Yan, Xiao-Dan; Wang, Ying; Jing, Songsong; Xiao, Pei‐Gen

doi:10.1002/cbdv.201300083

Cited by 36 publications

(24 citation statements)

References 44 publications

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“…Approximately hundreds of steroid saponins, a family of glycosides with a chemical structure that contains either a steroid or a triterpenoid attached via C-3 and an ether bond to a sugar side chain, have been extracted from Rhizoma Paridis, which are considered as the major bioactive ingredients of Paris species [18]. According to the configuration of C-25 and the cyclized state of F ring in the spirostanane structure, steroid saponins are divided into four types (Figure 1): (1) spirostanol, (2) isosprirostanol, (3) furostanol, and (4) pseudospirostanol [3]. Among them, isosprirostanol-type saponins are the main active substance basis of this genus.…”

Section: Chemical Structure Of Paris Saponins Derived From Rhizoma Paridismentioning

confidence: 99%

“…To understand their function and underlying mechanism, it is critical to analyze the major active substances within these plants. Recent phytochemical and pharmacological studies demonstrated that the extract of Rhizoma Paridis contains a large number of chemically active components, including steroid saponins, cholestanol, flavonoids, sterols, and triterpenoids [3][4][5][6]. e steroid saponins were shown to be the major effective ingredient exerting antitumor [7], antibacterial [8], antivirus [9], anti-inflammatory [10], hemostasis [11], immune regulation [7], antiliver fibrosis [12], and other biological functions.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Liu

Tian

et al. 2021

Journal of Chemistry

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Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

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Section: Chemical Structure Of Paris Saponins Derived From Rhizoma Paridismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Liu

Tian

et al. 2021

Journal of Chemistry

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“…The Paris is a genus of family Lilaceae which possess 24 species and many of them are herbal medicines (Wei et al, 2014) and out of 24 species 22 are found in China and its main center is South-west china (Zhao et al, 2014). The dry rhizome of paris is called paridis, which is the raw material for the patent chinese drugs including "Yunnan Baiyo," "GongXue Ning," and Jidesheng (snake tablet; Zhang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of anticancer activities of polyphyllin VII

et al. 2021

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Cancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant-derived compounds are considered safe, cost-effective and target cancer through different pathways. In these pathways include oxidative stress, mitochondrial dependent and independent, STAT3, NF-kB, MAPKs, cell cycle, and autophagy pathways. One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. In literature, there is a review gap of studies on PPVII; therefore in the current review, we summarized the available studies on PPVII to provide a base for future research.

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“…Chemical constituents of Paris include steroidal saponins, ecdysones, triterpenoid saponins, flavonoids and their glycosides, phenylpropanoids and their glycosides, pyrrolizidine alkaloids and so on. [9,14] Steroidal saponins (also named Paris saponins) are the major bioactive constituents of Paris, with a wide range of pharmacological activities including hemostatic, anti-tumor, antibacterial, anti-myocardial ischemia and immunomodulatory effects. [15] Among them, Polyphyllins I, II, VI and VII are the important index components to evaluate the quality of rhizoma Paridis and their preparations.…”

Section: Introductionmentioning

confidence: 99%

Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis

Gao

Chen

et al. 2021

Chemistry & Biodiversity

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Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. is a precious traditional Chinese medicine, and steroidal saponins are its major bioactive constituents possessing extensive biological activities. Squalene synthase (SQS) catalyzes the first dedicated step converting two molecular of farnesyl diphosphate (FDP) into squalene, a key intermediate in the biosynthetic pathway of steroidal saponins. In this study, a squalene synthase gene (PpSQS1) was cloned and functionally characterized from P. polyphylla var. yunnanensis, representing the first identified SQS from the genus Paris. The open reading frame of PpSQS1 is 1239 bp, which encodes a protein of 412 amino acids showing high similarity to those of other plant SQSs. Expression of PpSQS1 in Escherichia coli resulted in production of soluble recombinant proteins. Gas chromatography-mass spectrometry analysis showed that the purified recombinant PpSQS1 protein could produce squalene using FDP as a substrate in the in vitro enzymatic assay. qRT-PCR analysis indicated that PpSQS1 was highly expressed in rhizomes, consistent with the dominant accumulation of steroidal saponins there, suggesting that PpSQS1 is likely involved in the biosynthesis of steroidal saponins in the plant. The findings lay a foundation for further investigation on the biosynthesis and regulation of steroidal saponins, and also provide an alternative gene for manipulation of steroid production using synthetic biology.

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Chemical Constituents of Plants from the Genus Paris

Cited by 36 publications

References 44 publications

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Molecular mechanisms of anticancer activities of polyphyllin VII

Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis

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