Chemical Constituents of Propolis from Vietnamese <i>Trigona minor</i> and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line

Nguyen, Hai Xuan; Nguyen, Mai Thanh; Nguyen, Nhan Trung; Awale, Suresh

doi:10.1021/acs.jnatprod.7b00375

Cited by 50 publications

(44 citation statements)

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“…Only seven countries, including Brazil ( Melipona interrupta [ 126 ], M. quadrifasciata anthidioides [ 43 ], M. seminigra [ 126 ], M. scutellaris [ 139 ], M. subnitida [ 122 ], and Tetragonula (Trigona) spinipes [ 88 ] bees), Indonesia ( Tetragonula aff. biroi [ 42 ], T. sapiens [ 160 ], and T. incisa [ 136 ] bees), Malaysia ( Heterotrigona itama [ 149 ] bee), Philippines ( Tetragonula biroi [ 137 ] bee), Thailand ( Tetragonula laeviceps [ 138 ], T. pagdeni [ 151 ], and Tetrigona melanoleuca [ 138 ] bees), Vietnam ( Lisotrigona cacciae [ 157 ], L. furva [ 153 ], and Tetragonula minor [ 146 , 152 ] bees), and Australia ( Tetragonula carbonaria [ 131 , 140 ] bee) have published their SBP studies ( Figure 5 D). Vietnam is leading the numbers of compounds isolated from SBP, with 34 compounds, followed by Brazil (29 compounds) and Thailand (19 compounds).…”

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

“…Cinnamoyloxy-mammeisin present in this Brazilian SBP exhibited anti-inflammatory and antibacterial activities ( Table 2 ) [ 182 , 183 ]. Similarly to honey bees in Brazil [ 79 ], Myanmar [ 93 ], and Thailand [ 148 ], stingless bees in Indonesia [ 160 ] and Vietnam [ 146 ] also collect resin from Mangifera indica to produce propolis containing mainly cycloartane-type triterpenes.…”

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

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Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Tran

Ogbourne

Brooks

et al. 2020

IJMS

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Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing a broad spectrum of biological activities, it has gained significant scientific and commercial interest over the last two decades. As a result of searching 122 publications reported up to the end of 2019, we assembled a unique compound database consisting of 578 components isolated from both honey bee propolis and stingless bee propolis, and analyzed the chemical space and chemical diversity of these compounds. The results demonstrated that both honey bee propolis and stingless bee propolis are valuable sources for pharmaceutical and nutraceutical development.

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Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Tran

Ogbourne

Brooks

et al. 2020

IJMS

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“…The propolis of Tetrigona laeviceps and Tetrigona melanoleuca in Thailand contains a prenylated xanthone, α-mangostin, and dipterocarpol, a dammarane triterpene [17]. The propolis of a Vietnamese stingless bee, Trigona timor , contains cycloartane-type triterpenes [18].…”

Section: Introductionmentioning

confidence: 99%

“…The cypress is the major plant source of Maltese propolis, and Populus bud exudates are the main sources of the propolis of Bologna, Italy, and Algeria. The resin of Macaranga tanarius L. and Mangifera indica L. is the source of propolis from Japan, Myanmar, and Vietnam [18,20]. Garcinia mangostana is the primary source of propolis from Thailand [17].…”

Section: Introductionmentioning

confidence: 99%

Cycloartane-Type Triterpenes and Botanical Origin of Propolis of Stingless Indonesian Bee Tetragonula sapiens

Pujirahayu

Suzuki

Katayama

2019

Plants

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This study clarifies the chemical constituents and botanical origin of Tetragonula sapiens Cockerell bee propolis collected from Southeast Sulawesi, Indonesia. Propolis samples and resin of Mangifera indica were extracted with 99% ethanol to obtain an ethanol extract of propolis (EEP) and an ethanol extract of M. indica resin (EEM). Column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were developed and used for the separation and isolation of compounds from the ether-soluble fraction. The structure of the compounds was determined by nuclear magnetic resonance (NMR) spectroscopic analysis, and their molecular weight analyzed by gas chromatography–mass spectrometry (GC–MS). The HPLC chromatogram of the EEP was then compared with the HPLC chromatogram of EEM to investigate the botanical origin of propolis. Five compounds were isolated from the EEP, and their structures were determined as mangiferolic acid, cycloartenol, ambonic acid, mangiferonic acid, and ambolic acid, which are cycloartane-type triterpenes. The characteristic peak of the HPLC chromatograms of EEP and EEM showed a similar pattern, which is that the main components of propolis were also found in M. indica resin. These results suggested that the propolis from Southeast Sulawesi was rich in cycloartane-type triterpenes, and the plant source of the propolis could be Mangifera indica (mango).

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“…Furthermore, a dichloromethane extract of SBP displayed cytotoxic effects on head and neck squamous cell carcinoma (HNSCC) cell lines, resulting in reduced viability of these cells [ 94 ]. Novel compounds, 27-hydroxyisomangiferolic acid and 23-hydroxyisomangiferolic acid B, in the SBP extract displayed the highest levels of cytotoxicity against pancreatic cancer cells [ 95 ]. Further cytotoxic effects of SBP against canine osteosarcoma cells have been reported, with modulated cell morphologies and reduced viability of the cancer cells observed [ 109 ].…”

Section: Stingless Bee Propolis (Sbp)mentioning

confidence: 99%

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

et al. 2020

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Stingless bees are a type of honey producers that commonly live in tropical countries. Their use for honey is being abandoned due to its limited production. However, the recent improvements in stingless bee honey production, particularly in South East Asia, have brought stingless bee products back into the picture. Although there are many stingless bee species that produce a wide spread of products, known since old eras in traditional medicine, the modern medical community is still missing more investigational studies on stingless bee products. Whereas comprehensive studies in the current era attest to the biological and medicinal properties of honeybee (Apis mellifera) products, the properties of stingless bee products are less known. This review highlights for the first time the medicinal benefits of stingless bee products (honey, propolis, pollen and cerumen), recent investigations and promising future directions. This review emphasizes the potential antioxidant properties of these products that in turn play a vital role in preventing and treating diseases associated with oxidative stress, microbial infections and inflammatory disorders. Summarizing all these data and insights in one manuscript may increase the commercial value of stingless bee products as a food ingredient. This review will also highlight the utility of stingless bee products in the context of medicinal and therapeutic properties, some of which are yet to be discovered.

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Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line

Cited by 50 publications

References 44 publications

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Cycloartane-Type Triterpenes and Botanical Origin of Propolis of Stingless Indonesian Bee Tetragonula sapiens

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

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