CHEMICAL CONSTITUENTS OF Sinningia mauroana AND SCREENING OF ITS EXTRACTS FOR ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES

Abstract

7-O-glucoside. Complete NMR data of 6-hydroxy-7-methoxy-a-dunnione and 7-hydroxy-6-methoxy-a-dunnione were obtained in two different solvents. Hexane, ethyl acetate and ethanol extracts were screened for antimicrobial, antioxidant and cytotoxic activities. The antimicrobial activity was assayed against Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, C. parapsilosis, C. dubliniensis, and C. glabrata, using the microdillution method. All extracts were inactive (MIC > 100 mg mL-1). The antioxidant activity was evaluated with the ORAC method; the ethyl acetate and ethanol extracts were active (TE relative > 800 mg g-1). The cytotoxic activity was tested against PC-3 (prostate) and SKMEL-103 (melanoma) human tumor cell lines, and 3T3 fibroblast cell line, using the MTT assay. The hexane extract showed strong activity against PC-3 and SKMEL-103 human tumor cell lines (IC 50 < 0.25 and 3.07 mg mL-1 , respectively), and a lower activity towards 3T3 fibroblasts (IC 50 = 6.84 mg mL-1). The other extracts were inactive (IC 50 > 50 mg mL-1).

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

“…Altogether, 35 jacaranones were isolated from 37 plant species; three-quarters of the compounds are monomers ( n = 26), and the others are dimers ( n = 9) ( Figure 2 and Figure 3 ). Although the best sources of jacaranones are Asteraceae species, certain species of the Acanthaceae [ 3 ], Bignoniaceae [ 1 , 2 , 37 , 38 , 39 , 40 , 41 ], Delesseriaceae [ 42 ], Gesneriaceae [ 43 , 44 ], Oleaceae [ 45 ], and Theaceae [ 4 , 5 ] families were also found to be sources of jacaranones ( Table 2 ). Among Asteraceae species, the genus Senecio is represented by 20 jacaranone derivative-producing plant species [ 36 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ].…”

Correction: Chen et al. Cytotoxic, Antibacterial, and Antioxidant Activities of the Leaf Extract of Sinningia bullata. Plants 2023, 12, 859

“…Discussion", a new paragraph is added as the sixth paragraph: "Besides S. bullata, some other Sinningia species also have cytotoxic, antibacterial, and antioxidant activities. There are two scientific articles, clearly indicating that extracts of S. allagophylla [43] and S. mauroana [44] have strong cytotoxic activities. Compounds isolated from S. aggregata [45], S. reitzii [46], and S. leucotricha [47] have been further analyzed in cytotoxic activities.…”

“…Compounds isolated from S. aggregata [45], S. reitzii [46], and S. leucotricha [47] have been further analyzed in cytotoxic activities. The antibacterial and antioxidant properties of extracts and the isolated compounds from S. hatschbachii [48], S. magnifica [49], S. aggregata [50], S. warmingii [51], S. mauroana [44,52], and S. reitzii [53] have also been investigated experimentally. Unlike results in this study, however, most of these extracts did not have significant antibacterial activities.…”