Chemical Constituents of the Culture Broth of <i>Phellinus linteus</i> and Their Antioxidant Activity

Lee, Myeong-Seok; Hwang, Byung Kook; Lee, In‐Kyoung; Seo, Geon-Sik; Yun, Bong‐Sik

doi:10.5941/myco.2015.43.1.43

Cited by 23 publications

(21 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dai belongs to the order Hymenochaetales, and its species are prized as medicinal fungi. The medicinal functions of Sanghuangporus are antitumor, antioxidation, anti-inflammatory, hypoglycemic effect, hepatoprotective effect, and improving immunity (Dai et al, 2009; Lee et al, 2015; Zhu and Cui, 2016; Lin et al, 2017). Species in this genus form parasitic relationships with Alnus, Juglans, Lonicera, Morus, Populus, Quercus, Syringa , and Weigela (Dai, 2010; Wu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Species Diversity, Phylogeny, Divergence Time, and Biogeography of the Genus Sanghuangporus (Basidiomycota)

et al. 2019

View full text Add to dashboard Cite

“Sanghuang” is a popular fungus used as a Chinese traditional medicine. In fact, it represents a group of fungi belonging to the genus Sanghuangporus , but little is known about its origin and biogeography. The aim of this study was to characterize the molecular relationships, origin and biogeographical distribution of Sanghuangporus . The multi-locus phylogenetic analyses were used to infer the phylogenetic relationships. In addition, based on Bayesian evolutionary analysis using sequences from the internal transcribed spacer (ITS), nuclear large subunit rDNA (nLSU), translation elongation factor 1-α (EF1-α), and the largest and second largest subunits of RNA polymerase II (RPB1 and RPB2), we used a fungus fossil-based approach to gain insight into the divergence time of species in Sanghuangporus . The molecular phylogeny strongly supports the monophyly of Sanghuangporus (MP = 100%, ML = 100%, and BPP = 1.00), and 13 species are recognized in this genus. The Bayesian uncorrelated lognormal relaxed molecular clock using BEAST and reconstructed ancestral areas indicate that the maximum crown age of Sanghuangporus is approximately 30.85 million years. East Asia is the likely ancestral area (38%). Dispersal and differentiation to other continents then occurred during the late Middle Miocene and Pliocene. The ancestor of Sanghuangporus probably originated in palaeotropical Northeast Asia and covered Northeast Asia and East Africa during the Oligocene-Miocene, hosted by plants that expanded via the “Gomphotherium Landbridge.” Six kinds of dispersal routes are proposed, including intercontinental dispersal events of three clades between Northeast Asia and East Africa, between East Asia and North America, and between Northeast Asia and Europe.

show abstract

Section: Introductionmentioning

confidence: 99%

Species Diversity, Phylogeny, Divergence Time, and Biogeography of the Genus Sanghuangporus (Basidiomycota)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This role has been attributed to the biological activity of its various components, including polysaccharides, triterpenoids, polyphenols, and pyrans. Based on modern pharmacological studies, P. linteus is reported to have multifaceted biological activities, including anti-inflammatory [6,7,8,9,10,11,12,13,14], immunomodulatory [15,16,17,18,19], antioxidative [20,21,22,23,24,25,26], antimicrobial, and antiviral [27,28,29,30,31,32,33], as well as anticancer [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57], antidiabetic [58,59,60,61,62,63,64,65,66,67], hepatoprotective […”

Section: Introductionmentioning

confidence: 99%

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

et al. 2019

View full text Add to dashboard Cite

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.

show abstract

“…Quel, a wild macrofungi contains many bioactive compounds that have been reported to possess antibacterial, antioxidative, antitumor and antimutagenic activities, which have been widely used in China, Japan, and Korea for many years [1][2][3]. P. igniarius is rich in secondary metabolites with biological activities, such as polysaccharides, polyphenols, avonoids and other species [4,5]. A class of chemical compounds named Phelligridin from P. igniarius possess radicalscavenging activity and a broad pharmacological properties, such as Phelligridin D and Phelligridin G [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…(4) The cysteine in the peptide segment was modi ed to carbamidomethyl. (5) There was no variable modi cation of the peptide segment. (6) No methionine was found in the peptide segment.…”

mentioning

confidence: 99%

Screening for Proteins Related to The Biosynthesis of Hispidin and Its Derivatives in Phellinus Igniarius Using iTRAQ Proteomic Analysis

Guo

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Hispidin (HIP) and its derivatives, a class of natural fungal metabolites, possess extremely complex and interesting chemical structures with extensive pharmacological activities. Phellinus igniarius, which is the most common sources of HIP, can be used as both medicine and food. The biosynthetic pasthway of HIP in P. igniarius is not yet clear and hence effective regulatory mechanism of HIP is absent.The purpose of this paper was to illustrate a biosynthesis system for hispidin and its derivatives at the protein level. Results: We found that tricetolatone (TL) is a key biosynthetic precursor in the biosynthetic pathway of hispidin and that its addition led to increased production of hispidin and various hispidin derivatives. Based on the changes in the concentrations of precursors and intermediates, key timepoints in the biosynthetic process were identified. We used isobaric tags for relative and absolute quantification (iTRAQ) to study dynamic changes of related proteins in vitro. The 270 differentially expressed proteins were determined by GO enrichment analysis to be primarily related to energy metabolism, oxidative phosphorylation, and environmental stress responses after TL supplementation. The differentially expressed proteins were related to ATP synthase, NAD binding protein, oxidoreductase, and other elements associated with electron transfer and dehydrogenation reactions during the biosynthesis of hispidin and its derivatives. Multiple reaction monitoring (MRM) technology was used to selectively verify the iTRAQ results, leading us to screen 11 proteins that were predicted to be related to the biosynthesis pathways.Conclution: These findings help to clarify the molecular mechanism of biosynthesis of hispidin and its derivatives and may serve as a foundation for future strategies to identify new hispidin derivatives.

show abstract

Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity

Cited by 23 publications

References 23 publications

Species Diversity, Phylogeny, Divergence Time, and Biogeography of the Genus Sanghuangporus (Basidiomycota)

Species Diversity, Phylogeny, Divergence Time, and Biogeography of the Genus Sanghuangporus (Basidiomycota)

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

Screening for Proteins Related to The Biosynthesis of Hispidin and Its Derivatives in Phellinus Igniarius Using iTRAQ Proteomic Analysis

Contact Info

Product

Resources

About