Chemical Constituents of the Deep-Sea-Derived Penicillium solitum

He, Zhijun; Wu, Jia; Xu, Lin; Hu, Man-Yi; Xie, Mingming; Hao, You-Jia; Li, Shujin; Shao, Zongze; Yang, Xian‐Wen

doi:10.3390/md19100580

Cited by 9 publications

(7 citation statements)

References 33 publications

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“…Five other compounds were identified as 2‐(2' S ‐hydroxypropyl)‐5‐methyl‐7‐hydroxychromone ( 2 ), cyclonerodiol B ( 3 ), equisetin ( 4 ), 22 E ,24 R ‐ergosta‐7,22‐diene‐3β,5α,6β,9α‐tetraol ( 5 ), and N‐2’‐hydroxy‐3' E ‐octadecenoyl‐1‐O‐β‐ d ‐glucopyranosyl‐9‐methyl‐4 E ,8 E ‐sphingadiene ( 6 ) [21–25].…”

Section: Resultsmentioning

confidence: 99%

α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2

Fan

et al. 2022

J Basic Microbiol

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α-Glucosidase is the key enzyme on carbohydrate metabolism, and its bioactive inhibitors are supposed to be an effective therapeutic for type 2 diabetes mellitus. During our continuing study for discovering α-glucosidase inhibitors, a fungus GDZZ-G2 which is derived from a medicinal plant Callicarpa kwangtungensis Chun, exhibited significant inhibition on α-glucosidase. The strain was identified as Fusarium incarnatum by morphological and molecular methods. Further bioassay-guided fractionation result in six known secondary metabolites (1-6). All the compounds except 4 were isolated from F. incarnatum for the first time. Among them, an anthraquinonoid (S)-1,3,6-trihydroxy-7-(1-hydroxyethyl)anthracene-9,10dione (compound 1) exhibited strong inhibitory effect against α-glucosidase (IC 50 = 77.67 ± 0.67 μΜ), compared with acarbose (IC 50 = 711.8 ± 5 μΜ). An enzyme kinetics analysis revealed that compound 1 was an uncompetitive inhibitor. Besides, docking simulations predicted that compound 1 inhibited α-glucosidase substrate complex by binding Gln322, Gly306, Thr307, and Ser329 through hydrogen-bond interactions. Our findings suggested that compound 1 can be considered a lead compound for further modifications and the development of a new effective drug candidate in the treatment of type 2 diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2

Fan

et al. 2022

J Basic Microbiol

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“…215 Solitumergosterol A 585, is an unique 6/6/6/6/5 steroid obtained from P. solitum from deep-sea sediment, 216 as were polyketide 586 and alkaloids 587 and 588. 217 Penicillium steckii sourced from black band-diseased coral yielded new, 589 and 590, and known epithiodiketopiperazines with an a,b-polysulde bridge that underwent multiple nonenzymatic interconversions in solution. A further new analogue was present but not fully characterised.…”

Section: Natural Product Reports Reviewmentioning

confidence: 99%

“…215 Solitumergosterol A 585 , is an unique 6/6/6/6/5 steroid obtained from P. solitum from deep-sea sediment, 216 as were polyketide 586 and alkaloids 587 and 588 . 217…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2023

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“…TW58-16 [62]. 15-O-methyl ML-236A (191) (Figure 4) was isolated from the deep-sea-sediment-derived P. solitum MCCC 3A00215 [69].…”

Section: Other Polyketidesmentioning

confidence: 99%

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

Lv,

Zeng

2024

Marine Drugs

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Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.

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Chemical Constituents of the Deep-Sea-Derived Penicillium solitum

Cited by 9 publications

References 33 publications

α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2

α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2

Marine natural products

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

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