Chemical Constituents of the Genus <i>Polygonatum</i> and their Role in Medicinal Treatment

Zhao, Xueying; Li, Ji

doi:10.1177/1934578x1501000439

Cited by 38 publications

(44 citation statements)

References 42 publications

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“…Polygonatum stenophyllum rhizome, which belongs to family Liliaceae (also named Convallariaceae), is distributed across East Asia [15]. P. stenophyllum, a traditional herbal remedy, has been used as an anti-aging, antioxidant, and anti-atherosclerotic agent in the medical treatment of various diseases [16].…”

Section: Introductionmentioning

confidence: 99%

Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Lee

Kim

et al. 2016

J Nat Med

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Menopausal women are associated with an increase in obesity accompanying changes in the body's condition and composition. Polygonatum stenophyllum (PS) rhizome, which is a traditional herbal remedy, has been used to treat various diseases including obesity. However, the effect of PS on menopausal obesity remains unclear. Female C57BL/6 mice were ovariectomized (OVX) and fed on high fat diet (HFD) to induce menopausal obesity. Aqueous extract of PS of 1, 10, and 100 mg/kg was orally administrated for 6 weeks after 7 weeks of induction. The weights of body, uterine, and ovarian fat were investigated. Histological analysis was performed to monitor the changes of liver and fat. In addition, lipid profiles were measured in serum and the expression of lipolysis-related enzymes was analyzed in uterine tissues. PS significantly decreased the weights of body and ovarian fat and increased the uterine weight compared to control group. Administration of PS significantly decreased the adipocyte diameter and the lipid droplets within the hepatocytes. In addition, PS-treated mice had lower levels of triglyceride (TG), total cholesterol, and LDL-cholesterol than control mice. The expression of lipolysis-related genes, including adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), was increased in PS-treated groups. Taken together, these results demonstrate that PS might have efficacy on menopausal obesity by activating ATGL and HSL.

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Section: Introductionmentioning

confidence: 99%

Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Lee

Kim

et al. 2016

J Nat Med

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“…The major extract from Polygonatum sibiricum is Polygonatum sibiricum polysaccharides (PSP) mainly consisting of mannose, galactose, glucose, and xylose, which is also rich in various bioactive components such as alkaloids, steroidal saponins, flavonoids, and lignin [3,4]. In recent years, PSP has been reported to have many pharmacological applications and biological activities, such as antioxidant, antiaging, antiosteoporosis, antidiabetes, anticancer, and antifatigue, as well as immune enhancement, neuroprotection [5,6].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Polygonatum sibiricum Polysaccharides on Apoptosis, Inflammation, and Oxidative Stress in Nucleus Pulposus Cells of Rats with the Degeneration of the Intervertebral Disc

Zhai

et al. 2019

International Journal of Polymer Science

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Objective. Polygonatum sibiricum polysaccharide (PSP) has antioxidant activity, immune enhancement, and other biological properties. However, the effect of PSP on intervertebral disc degeneration has not been reported. In this study, we mainly investigated the effect of PSP on the apoptosis, inflammation, and oxidative stress of nucleus pulposus cells (NPCs) during the process of intervertebral disc degeneration. Methods. A rat NPC model induced by H2O2 was constructed. The CCK8 method was used to measure the effects of PSP on the apoptosis of rat NPCs induced by H2O2. The effects on the activity of SOD and content of MDA were also determined. The rat model of intervertebral disc degeneration was treated with PSP for 1 month, and the mRNA expression levels of IL-1β, COX2, iNOS, Col2α1, Col10α1, and MMP3 were measured by qPCR in the tissue of intervertebral disc. NPCs from the degenerated intervertebral discs were separated, and the cell viability was measured by the CCK8 method. The contents of SOD and MDA in NPCs were determined as well. Results. PSP significantly reduced the apoptosis of NPCs induced by H2O2, significantly increased the SOD content, and decreased the content of MDA in H2O2-induced NPCs. The expression level of IL-1β, COX2, and iNOS in the rat model with intervertebral disc degeneration was significantly downregulated after 1 month of PSP treatment. PSP treatment increased the expression of Col2α1 type and significantly decreased the expression of Col10α1 type collagen and MMP3 in rats with disc degeneration. PSP treatment significantly reduced NPC apoptosis and increased its SOD content and reduced MDA content, which is consistent with the results from cell-level experiments. Conclusion. PSP can effectively reduce the apoptosis, inflammation, and oxidative stress of H2O2-induced NPCs in rats with intervertebral disc degeneration and mitigate the progression of intervertebral disc degeneration, which has the potential to be developed as new drugs for the treatment of intervertebral disc degeneration.

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“…Polygonatum cyrtonema Hua (Liliaceae) is a perennial plant that grows mainly in the temperate regions of the northern hemisphere, including China, Japan, Korea, and Russia [ 1]. Due to its antioxidant, anti-aging, and neuroprotective effects, P. cyrtonema is widely used as a traditional Chinese medicine for the treatment of cardiovascular and other diseases in China [ 2,3]. The rich biological activity of P. cyrtonema is attributed to the presence of various compounds such as alkaloids, flavonoids, steroidal saponins, lignin, and polysaccharides [ 2,4], and polysaccharides are considered as one of the most important groups of active compounds in P. cyrtonema [ 5,6].…”

Section: Introductionmentioning

confidence: 99%

Identification, expression analysis, and potential roles of microRNAs in the regulation of polysaccharide biosynthesis in Polygonatum cyrtonema Hua

Zhang

Peng

et al. 2019

Preprint

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Background: MicroRNAs (miRNAs) are a group of endogenous small non-coding RNAs with important roles in plant growth, development, and metabolic processes. Polygonatum cyrtonema Hua (P. cyrtonema) is an important Chinese traditional medicinal herb with broad pharmacological functions, and polysaccharides are the main biological substance accumulated in the P. cyrtonema rhizome. However, regulation of the process of polysaccharide biosynthesis in P. cyrtonema remains largely unknown. Results: To elucidate the miRNAs and their targets involved in polysaccharide biosynthesis in P. cyrtonema, four small RNA libraries were constructed from flower, leaf, rhizome, and root tissues and sequenced. A total of 69 conserved and 5 novel miRNAs were identified, of which 6 miRNAs (miR156a-5p, miR156f-5p, miR395a_5, miR396a-3p, miR396g-3p, and miR397-5p_1) were down-regulated and 7 miRNAs (miR160, miR160h_1, miR160e-5p, miR319b_1, miR319_1, miR319c-5p_3, and miR319c_1) were up-regulated in rhizomes compared with flower, leaf, and root tissues. Bioinformatics analysis showed that the predicted targets of these miRNAs were mostly transcription factors and functional genes enriched in metabolic and secondary metabolite biosynthetic pathways, and 7 genes and their paired miRNAs were identified in carbohydrate metabolism. qRT-PCR expression analysis demonstrated that 6 miRNAs and their targets involved in carbohydrate metabolism were existed a negative correlation in. P. cyrtonema tissues. MiR396a-3p and one of its target genes, abfA, were possibly involed in polysaccharide biosynthesis pathway. Conclusions: This is the first report on the identification of conserved and novel miRNAs and their potential targets in P. cyrtonema, thus providing molecular evidence for the role of miRNAs in the regulation of polysaccharide biosynthesis in P. cyrtonema.

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Chemical Constituents of the Genus Polygonatum and their Role in Medicinal Treatment

Cited by 38 publications

References 42 publications

Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Protective Effect of Polygonatum sibiricum Polysaccharides on Apoptosis, Inflammation, and Oxidative Stress in Nucleus Pulposus Cells of Rats with the Degeneration of the Intervertebral Disc

Identification, expression analysis, and potential roles of microRNAs in the regulation of polysaccharide biosynthesis in Polygonatum cyrtonema Hua

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