Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Lee, Ji Eun; Kim, Eunjung; Kim, Mi Hye; Ji, Hong; Yang, Woong Mο

doi:10.1007/s11418-016-1018-9

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Furthermore, other Polygonatum species have a history of medicinal use, with various species having different medicinal effects. P. cirrhifolium can reduce oxidative stress for the protection of neurons ( Xu et al, 2017 ); P. odoratum can be used to inhibit the proliferation of cancer cells ( Tai et al, 2016 ); and P. stenophyllum can suppress menopausal obesity ( Lee et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Study of Different Germplasm Resources for Three Polygonatum Species Using UPLC-Q-TOF-MS/MS

Wang

Zhang

et al. 2022

Front. Plant Sci.

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Rhizomes of the Polygonatum species are well-known in traditional Chinese medicine. The 2020 edition of Chinese Pharmacopoeia includes three different species that possess different pharmacological effects. Due to the lack of standardized discriminant compounds there has often been inadvertently incorrect prescriptions given for these medicines, resulting in serious consequences. Therefore, it is critical to accurately distinguish these herbal Polygonatum species. For this study, UPLC-Q-TOF-MS/MS based metabolomics was employed for the first time to discriminate between three Polygonatum species. Partial least squares discriminant analysis (PLS-DA) models were utilized to select the potential candidate discriminant compounds, after which MS/MS fragmentation patterns were used to identify them. Meanwhile, metabolic correlations were identified using the R language package corrplot, and the distribution of various metabolites was analyzed by box plot and the Z-score graph. As a result, we found that adenosine, sucrose, and pyroglutamic acid were suitable for the identification of different Polygonatum species. In conclusion, this study articulates how various herbal Polygonatum species might be more accurately and efficiently distinguished.

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Section: Introductionmentioning

confidence: 99%

Metabolomics Study of Different Germplasm Resources for Three Polygonatum Species Using UPLC-Q-TOF-MS/MS

Wang

Zhang

et al. 2022

Front. Plant Sci.

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“…The rhizome of Polygonatum sibiricum Redoute (PSR) has long been used to treat metabolic disorders such as diabetes-associated complications. Recently, numerous studies has demonstrated that Polygonatum stenophyllum [20], Polygonatum sibiricum polysaccharides [21], Polygonatum sibiricum rhizome ethanol extract [22] could protect against obesity in either human individuals or HFD-fed mice.…”

Section: Psrwe Treatment Signi Cantly Improved Hfd-induced Obesity An...mentioning

confidence: 99%

Multiomics reveals the ameliorating effect and underlying mechanism of polygonatum sibiricum rhizome water extract on HFD-induced mouse obesity

Wang

et al. 2023

Preprint

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Background Polysaccharides and ethanol extract from Polygonatum sibiricum rhizome were reported to improve high-fat diet (HFD)-fed mouse obesity. However, the effect and potential mechanism of Polygonatum sibiricum rhizome water extract (PSRwe) on HFD-induced obesity mice remains unclear. The present study was sought to comprehensively elucidate that. An obese mouse model was established by feeding HFD and PSRwe were intragastrically administered once a day for 40 days. Changes in body weight, gut microbiota and their metabolites, plasma and liver metabolomics, colonic and liver transcriptomics were explored. The compounds in PSRwe were also examined.Results Body weight was significantly reduced after two weeks of PSRwe administration. Meanwhile, PSRwe treatment has significantly recovered the richness and diversity of gut microbiota in HFD-caused obesity mice. Specifically, beneficial species including Akkermansia muciniphila and functional pathways including fatty acids biosythesis and elongation, pentose phosphate pathway, glycolysis and reductive TCA cycle were significantly enriched in PSRwe group compared with oebsity. RNA-seq revealed that the function of the up-regulated DEGs in liver of PSRwe mice were mainly concentrated on lipid and fatty acid oxidation and metabolism, while the down-regulated DEGs were mainly focused on sterols and sterol biosynthesis and metabolism. In colon, however, the function of up-regulated DEGs were primarily JAK-STAT/PI3K-Akt signaling pathway, regulation of GTPase activity, and response to cation while the down-regulated DEGs were centered on glycolysis, fructose/mannose/pyruvate metabolism, fat digestion and absorption, and PPAR signaling pathway. Metabolomics analysis indicated that betaine, an effective component from PSR water extracts, has showed higher levels in both liver and plasma of PSRwe-treated mice, indicating that it was significantly associated with obesity. In addition, correlation analysis showed that the significantly different species enriched in PSRwe group were negatively correlated with colonic DEGs related on PPAR signaling pathway, glycolysis etc. but positively correlated with JAK-STAT signaling pathway etc. Intriguingly, common metabolites in plasma and liver were negatively correlated with liver DEGs related on steroids and sterols biosynthesis and metabolism but positively correlated with fatty acid metabolism.Conclusions Collectively, our study demonstrated that PSRwe could significantly alleviate HFD-induced mouse obesity via either directly affect lipid metabolism through effective betaine or by changing gut microbiota and their metabolites to alter gene expression associated with fatty acid metabolism in liver and colon, suggesting PSRwe might be a promising therapeutic candidate for obesity in clinical.

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“…Polygonatum stenophyllum (PS) Maxim. rhizome showed efficacy on menopausal obesity by activating lipolysisrelated genes including hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) (Lee J. E. et al, 2016). Mulberry (Fructus Mori) water extracts promoted hepatic lipolysis and protected liver from steatosis in obesity (Peng et al, 2011).…”

Section: Increasing Lipolysismentioning

confidence: 99%

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

Guo

et al. 2020

Front. Pharmacol.

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The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes of liver steatosis. The application of herbal medicines with anti-oxidative stress and lipid-balancing properties has been extensively attempted as pharmaceutical intervention for liver disorders in experimental and clinical studies. Although the molecular mechanisms underlying their hepatoprotective effects warrant further exploration, increasing evidence demonstrated that many herbal medicines are involved in regulating lipid accumulation processes including hepatic lipolytic and lipogenic pathways, such as mitochondrial and peroxisomal b-oxidation, the secretion of very low density lipoprotein (VLDL), the non-esterified fatty acid (NEFA) uptake, and some vital hepatic lipogenic enzymes. Therefore, in this review, the pathways or crucial mediators participated in the dysregulation of hepatic lipid metabolism are systematically summarized, followed by the current evidences and advances in the positive impacts of herbal medicines and natural products on the lipid metabolism pathways are detailed. Furthermore, several herbal formulas, herbs or herbal derivatives, such as Erchen Dection, Danshen, resveratrol, and berberine, which have been extensively studied for their promising potential in mediating lipid metabolism, are particularly highlighted in this review. FIGURE 1 | Major processes involved in hepatic lipid metabolism. Li et al.

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Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes

Cited by 4 publications

References 31 publications

Metabolomics Study of Different Germplasm Resources for Three Polygonatum Species Using UPLC-Q-TOF-MS/MS

Metabolomics Study of Different Germplasm Resources for Three Polygonatum Species Using UPLC-Q-TOF-MS/MS

Multiomics reveals the ameliorating effect and underlying mechanism of polygonatum sibiricum rhizome water extract on HFD-induced mouse obesity

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

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